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Reworking method of cefpirome sulfate mixed powder

A technology of mixing powder of cefpirome sulfate and roxime, which is applied in the direction of organic chemistry, etc., can solve the problems of waste and high price, and achieve the effect of reducing costs

Active Publication Date: 2015-04-01
苏州盛达药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because there are many links in the synthetic production, the route is long, and the price is expensive, the color, content, impurities, sterility, and visible foreign matter caused by other reasons sometimes fail during the preparation process. For the unqualified cefpirome sulfate mixed Sodium carbonate mixed powder is discarded, which is more wasteful

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 20g of cefpirome sulfate mixed powder to be reworked is dissolved in 120ml of water, the dissolved solution is passed through 732 type cation exchange resin, 160ml of filtrate is collected, 1g of activated carbon is added in the filtrate to carry out decolorization reaction, and the reaction time is controlled at 30min. Filtrate, adjust the pH of the filtrate to the optimum pH of 1.6 to 2.0 with sulfuric acid solution, add acetone to crystallize, control the reaction temperature during crystallization at 18°C ​​to 22°C, and stir for 2 to 4 hours to end the reaction, filter, and obtain filtered The crystallization, the crystallization after washing and filtering with acetone mixed solution, vacuum drying at 45~55 ℃ until moisture is qualified, obtains cefpirome sulfate 15.6g, the rate of recovery of cefpirome sulfate mixed powder to be reworked can reach 78.0%.

Embodiment 2

[0033] 20g of cefpirome sulfate mixed powder to be reworked is dissolved in 120ml of water, the dissolved solution is passed through 107 type cation exchange resins, 160ml of filtrate is collected, 1g of activated carbon is added in the filtrate for decolorization reaction, and the reaction time is controlled at 30min. Use sulfuric acid solution to adjust the pH of the filtrate to the optimum pH value of 1.6-2.0, add alcohol for crystallization, control the reaction temperature during crystallization at 18°C-22°C, and stir for 2-4h, end the reaction, filter, and obtain filtered crystals , wash and filter the crystals with acetone mixed solution, vacuum-dry at 45-55° C. until the moisture is qualified, and obtain 16.0 g of cefpirome sulfate, and the recovery rate of cefpirome sulfate mixed powder to be reworked can reach 80.0%.

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PUM

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Abstract

The invention discloses a reworking method of cefpirome sulfate mixed powder. The reworking method comprises the following steps of: 1) dissolving the cefpirome sulfate mixed powder to be reworked in a certain amount of water, and setting the temperature at 0 DEG C-30 DEG C; 2) enabling the solution after dissolution to pass through a column loaded with an adsorbent, and collecting filtrate; 3) adding activated carbon into the filtrate, performing decolorization reaction, and controlling the reaction time at 30min; 4) filtering and collecting the filtrate; 5) dripping a sulfuric acid solution into the filtrate, and regulating the PH value to 1.2-2.4; 6) adding a crystallizing agent into the filtrate for crystallization, controlling the crystallization temperature at 0 DEG C-30 DEG C, and stirring for 2-4h; 7) filtering to obtain a crystal after filtration, and washing with one solution or a mixed solution of acetone and alcohol; and 8) controlling the temperature at 45 DEG C-55 DEG C, and drying to obtain the cefpirome sulfate. According to the reworking method disclosed by the invention, the unqualified cefpirome sulfate can be effectively reworked and refined to produce a qualified product, and the cost can be further reduced.

Description

technical field [0001] The invention relates to a method for reworking cefpirome sulfate mixed powder. Background technique [0002] Cefpirome sulfate is the fourth generation of broad-spectrum cephalosporin antibiotics. It has the characteristics of broad-spectrum and high-efficiency inhibition of β-lactamase. It is clinically used for the treatment of patients with moderate and severe infections. Because cefpirome sulfate itself is slightly soluble in water, and is acidic, so it is used clinically as an injection and is generally mixed with sodium carbonate to form a powder. Because there are many links in the synthetic production, the route is long, and the price is expensive, the color, content, impurities, sterility, and visible foreign matter caused by other reasons sometimes fail during the preparation process. For the unqualified cefpirome sulfate mixed The mixed powder of sodium carbonate is discarded, which is more wasteful. Contents of the invention [0003] F...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D501/46C07D501/12
Inventor 周自金吕德新曾润保冷雄军温雄飞
Owner 苏州盛达药业有限公司
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