Green coffee bean extract sustained-release tablet and preparation method thereof
A green coffee bean and extract technology, applied in the field of green coffee bean extract sustained-release tablets, can solve problems such as user discomfort and adverse reactions, increase weight loss and fat-lowering effects, eliminate discomfort, improve weight loss and lipid-lowering Effect
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[0019] Example 1
[0020] Pre-mix 20%wt of green coffee bean extract (containing 50% chlorogenic acid), 10%wt of HPMC (E50), 0.2%wt of pre-cured starch, and use GHL high-speed mixing granulator for mixing Granulation, shearing at medium / high speed, stirring at medium / low speed, mixing uniformly and breaking agglomerates; use 80% alcohol solution to spray the mixture of green coffee bean extract, HPMC and pre-crossed starch The spray time is about 15 minutes. The amount of alcohol solution used is 15-50%wt of the component formula. After the alcohol solution is added, the mixture is wet mixed (shearing at high speed, stirring at medium / low speed) 1 -2 minutes to obtain pellets; crush the obtained pellets, break up the larger agglomerates, and pass the swing granulator to obtain smaller particles. Dry the particles with a fluidized bed dryer or an oven with a drying loss of 3%-9%; crush the particles and sieve with 12-20 mesh to obtain the required particle size. Continue to add ...
Example Embodiment
[0021] Example 2
[0022] The steps described in Example 1, wherein the contents of each component are: 50%wt of green coffee bean extract, 40%wt of HPMC, 2.0%wt of stearic acid, 4.0%wt of gastric soluble film Coating powder, the balance is lactose. The obtained tablets are 1000 mg / tablet, and each tablet contains 500 mg of green coffee extract.
Example Embodiment
[0023] Example 3
[0024] The steps described in Example 1, wherein the content of each component is: 30%wt of green coffee bean extract, 20%wt of HPMC, 46%wt of sugar alcohol, 3%wt of gastric-soluble film package Coating powder, 1%wt magnesium stearate. The obtained tablets are 1000 mg / tablet, and each tablet contains 300 mg of green coffee extract.
[0025] Comparative test 1
[0026] Take the green coffee bean extract sustained-release tablets obtained in the above Examples 1-3 for a comparative test. Forty-eight people (half men and women, aged between 23-45 years old) are randomly selected as the test subjects. A group of 16 people is used for the test. 3 groups, 8 people in each group, half of the test subjects, as the experimental group, took the sustained-release tablets of Example 1-3 as the experimental group, each took 1 tablet each time, 3 times a day, morning, afternoon, and evening for 6 months. , Record the weight change of the test subjects; the other half of the t...
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