Green coffee bean extract sustained-release tablet and preparation method thereof

A green coffee bean and extract technology, applied in the field of green coffee bean extract sustained-release tablets, can solve problems such as user discomfort and adverse reactions, increase weight loss and fat-lowering effects, eliminate discomfort, improve weight loss and lipid-lowering Effect

Inactive Publication Date: 2013-05-15
ANJI E SWEET CANDY FOOD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims at the disadvantages of using green coffee bean extracts in the prior art, which may cause discomfort and adverse reactions to users, and provides a new type of

Method used

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  • Green coffee bean extract sustained-release tablet and preparation method thereof
  • Green coffee bean extract sustained-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0019] Example 1

[0020] Pre-mix 20%wt of green coffee bean extract (containing 50% chlorogenic acid), 10%wt of HPMC (E50), 0.2%wt of pre-cured starch, and use GHL high-speed mixing granulator for mixing Granulation, shearing at medium / high speed, stirring at medium / low speed, mixing uniformly and breaking agglomerates; use 80% alcohol solution to spray the mixture of green coffee bean extract, HPMC and pre-crossed starch The spray time is about 15 minutes. The amount of alcohol solution used is 15-50%wt of the component formula. After the alcohol solution is added, the mixture is wet mixed (shearing at high speed, stirring at medium / low speed) 1 -2 minutes to obtain pellets; crush the obtained pellets, break up the larger agglomerates, and pass the swing granulator to obtain smaller particles. Dry the particles with a fluidized bed dryer or an oven with a drying loss of 3%-9%; crush the particles and sieve with 12-20 mesh to obtain the required particle size. Continue to add ...

Example Embodiment

[0021] Example 2

[0022] The steps described in Example 1, wherein the contents of each component are: 50%wt of green coffee bean extract, 40%wt of HPMC, 2.0%wt of stearic acid, 4.0%wt of gastric soluble film Coating powder, the balance is lactose. The obtained tablets are 1000 mg / tablet, and each tablet contains 500 mg of green coffee extract.

Example Embodiment

[0023] Example 3

[0024] The steps described in Example 1, wherein the content of each component is: 30%wt of green coffee bean extract, 20%wt of HPMC, 46%wt of sugar alcohol, 3%wt of gastric-soluble film package Coating powder, 1%wt magnesium stearate. The obtained tablets are 1000 mg / tablet, and each tablet contains 300 mg of green coffee extract.

[0025] Comparative test 1

[0026] Take the green coffee bean extract sustained-release tablets obtained in the above Examples 1-3 for a comparative test. Forty-eight people (half men and women, aged between 23-45 years old) are randomly selected as the test subjects. A group of 16 people is used for the test. 3 groups, 8 people in each group, half of the test subjects, as the experimental group, took the sustained-release tablets of Example 1-3 as the experimental group, each took 1 tablet each time, 3 times a day, morning, afternoon, and evening for 6 months. , Record the weight change of the test subjects; the other half of the t...

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Abstract

The invention relates to the manufacturing field of food and drugs, and discloses a green coffee bean extract sustained-release tablet. The green coffee bean extract sustained-release tablet comprises the following components: 20%-50%wt of green coffee bean extract, 10%-40%wt of hydroxy propyl methyl cellulose (HPMC), 0.2%-4.0%wt of lubricating agent, 2.0%-4.0%wt of stomach-soluble film coating powder and the balance of excipient. The invention further discloses a preparation method of the sustained-release tablet. The green coffee bean extract sustained-release tablet has the advantages of better weight loss effect, slight uncomfortableness after orally taking and high application value.

Description

technical field [0001] The invention relates to the field of food and drug manufacture, in particular to a sustained-release tablet of green coffee bean extract and a preparation method of the sustained-release tablet. Background technique [0002] Chlorogenic acid has a wide range of antibacterial effects, but it can be inactivated by proteins in the body. Similar to caffeic acid, when taken orally or intraperitoneally, it can increase the excitability of the central nervous system, increase the peristalsis of the gastrointestinal tract, especially the small intestine, and increase the secretion of bile. At present, chlorogenic acid has many applications in weight loss and lipid lowering. Green coffee bean extract contains more chlorogenic acid, so it is often used as an effective source of chlorogenic acid. Therefore, green coffee bean extract is widely used in the field of weight loss and fat reduction . Existing studies have pointed out that direct consumption of gree...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/28A61K47/38A61P3/04A61P3/06
Inventor 金杰
Owner ANJI E SWEET CANDY FOOD
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