Preparation method of radioactivity lung injury rabbit-step model

A radioactive lung injury and ladder technology, applied in the field of medical models, can solve the problems of poor effect, radiation sensitivity, and high mortality, and achieve the effects of short modeling time, easy replication, and low model mortality.

Inactive Publication Date: 2013-05-15
胡晓云
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Problems solved by technology

In the previous literature, mice or rats were mostly used to establish animal models of radiation-induced lung injury, but due to their sensitivity to radiation, the mortality rate was relatively high, and only a few could survive to advanced pulmonary fibrosis; The effect of radiation lung injury model on CT, MR and nuclear medicine imaging to study the mechanism of radiation lung injury is not good

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Embodiment Construction

[0013] The present invention will be further described below in conjunction with specific examples.

[0014] A preparation method of a rabbit ladder model of radiation-induced lung injury comprises the following steps:

[0015] New Zealand white rabbits, regardless of sex, aged 1.0-1.2 years, and weighing 2.0-3.0 kg, were randomly divided into an experimental group and a control group with the same total number of groups and the same number of rabbits in each group; the experimental group and the control group were both After intramuscular injection of anesthesia, CT scanning of the whole lung is performed first, and then the target area is delineated, and then the radiotherapy three-dimensional plan (TPS, CMS Xio type) for unilateral lung irradiation field design and dose calculation is performed. Both the lower and contralateral thorax were covered with lead blocks; the experimental group was irradiated by a linear accelerator (SIEMENS Primus M), with the front and rear faci...

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Abstract

The invention relates to a preparation method of a radioactivity lung injury rabbit-step model. The preparation method of the radioactivity lung injury rabbit-step model is characterized in that anesthesia is carried out through intramuscular injection, and then a single full lung field gray high-energy x ray is used for radiating after fixing is achieved. In addition, a control group which is healthy and not radiated is established, observation research is carried out in different time points after radiation, and finally a radioactivity lung injury rabbit-step model is successfully established after being verified by results of blood serum, pathology, an electron microscope, high-resolution computed tomography (CT), CT perfusion weighted imaging and the like. An animal model established by the preparation method can well simulate happening and developing regular patterns and characteristics of human radioactivity lung injury, and has the advantages of being simple in model manufacturing operation, low in model manufacturing cost, short in model completing time, low in model dead rate, easy to duplicate, good in controllability, good in imaging effect and the like, beneficially for radioactivity lung injury experiment study and medical development and study such as relevant follow-up treatment, curative effect evaluation, and has scale popularization and application value.

Description

technical field [0001] The invention discloses a method for preparing an animal model for studying the pathological mechanism, occurrence rule, image diagnosis and evaluation of radiation-induced lung injury. The invention belongs to the technical field of medical models. Background technique [0002] Radiation lung injury is a common complication of radiotherapy for thoracic tumors. The incidence of symptomatic radiation lung injury is as high as 30%. The process can be irreversible and eventually lead to severe respiratory failure. Therefore, radiation-induced lung injury has become a major limiting factor in radiotherapy for thoracic tumors. So far, radiation-induced lung injury is still based on the comprehensive judgment of conventional imaging methods (chest plain film and CT examination) and clinical manifestations, among which the positive manifestations of high-resolution CT (HRCT) are currently a relatively objective and accurate basis. But unfortunately, when HRC...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/00
Inventor 方向明胡晓云
Owner 胡晓云
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