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Graphene oxide supported benazepril compound as well as preparation method and application thereof

A benazepril and compound technology, which is applied to the graphene oxide-supported benazepril compound and its preparation and application fields, can solve the problems of poor water solubility, low utilization rate, short duration of drug effect, etc. The effect of high loading rate, prolonged action time, and reduced frequency of medication

Active Publication Date: 2014-12-10
NAT UNIV OF DEFENSE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Benazepril's poor water solubility, low utilization rate, and short duration of drug effect have brought a lot of inconvenience to the clinical application of the drug. Therefore, it is urgent to study and develop drug carriers to load it to solve the problem. above question

Method used

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  • Graphene oxide supported benazepril compound as well as preparation method and application thereof
  • Graphene oxide supported benazepril compound as well as preparation method and application thereof
  • Graphene oxide supported benazepril compound as well as preparation method and application thereof

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Embodiment

[0036] a kind of like Figure 1 to Figure 5 The graphene oxide-supported benazepril compound of the present invention is shown, which comprises graphene oxide and benazepril, and the surface of graphene oxide contains one of hydroxyl, carbonyl, carboxyl, and epoxy groups or multiple (see figure 1 ), benazepril is adsorbed on the surface of graphene oxide molecules. In this embodiment, the loading capacity of graphene oxide on benazepril is 1.12 mg / mg (after the complex is centrifuged, the residue of benazepril in the solution is detected, so that the combined benazepril in the complex can be calculated amount). The complex is a cake-like complex that has pH-responsive properties for the release of benazepril contained therein (see Figure 5 ).

[0037] A preparation method of the compound of graphene oxide loaded benazepril of the present embodiment, comprises the following steps:

[0038] (1) Generation of graphite intercalation compounds: put a three-necked round-botto...

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Abstract

The invention discloses a graphene oxide supported benazepril compound as well as a preparation method and application thereof. The compound comprises graphene oxide and benazepril; and the surface of the graphene oxide contains one or more of hydroxyl, carbonyl, carboxyl and epoxy group; and the benazepril is adsorbed on the surface of a graphene oxide molecule. The preparation method disclosed by the invention comprises the following steps of: evenly mixing the graphene oxide with a benazepril solution according to a certain volume ratio; oscillating over the night, centrifuging the mixed solution at a certain rotating speed, taking sediment, and freezing and drying to obtain graphene oxide-medicine compound. The compound disclosed by the invention can be applied as a controlled release carrier of the benazepril. The compound disclosed by the invention is high in supporting rate; the release has pH response characteristic; the action time of the benazepril can be prolonged by application of the compound; and the frequency of medication is reduced.

Description

technical field [0001] The invention relates to a compound containing drug components and its preparation and application, in particular to a drug slow-release carrier and its preparation method and application. Background technique [0002] Benazepril is a broad-spectrum antihypertensive drug that can dilate arteries and veins, reduce peripheral vascular resistance or afterload, reduce pulmonary capillary entrapment or preload, and reduce pulmonary vascular resistance, thereby improving cardiac output , Increase exercise tolerance and prolong exercise time. [0003] Benazepril has poor water solubility and cannot be well dissolved in water, which leads to being unable to be well absorbed in the human body; its drug utilization rate is low, and the absorption effect is not good, only about 37%, most of which are absorbed in the body. Lost in the form of transformation or excretion, it is difficult to achieve the desired drug effect. The peak time of benazepril in the body ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/55A61K47/04A61P9/12
Inventor 王建方龙吟陶呈安邹晓蓉朱慧肖华盛丽萍胡智宏
Owner NAT UNIV OF DEFENSE TECH
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