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Micronized Chinese yew particles, compound for health bath obtained by using Chinese yew micronized particle and preparation method thereof

A technology of micronized particles and compositions, which is applied in the direction of drug combinations, medical preparations containing active ingredients, medical raw materials derived from gymnosperms, etc., and can solve problems such as adhesion, low efficiency, and poor effect

Inactive Publication Date: 2014-07-09
朱乃根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are also problems in the direct pulverization of many pharmaceutical solid powders. For example, direct pulverization by airflow pulverization will have disadvantages such as agglomeration, blockage of the cavity, and low efficiency; and direct pulverization by ball milling will have adhesion, cake formation, and poor effect, etc. shortcoming
These shortcomings will lead to the inability of the drug micronization process to be scaled and industrialized, even in the laboratory.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: adding solid micronization aids, common salt and yew stem bark and coarse powder of roots are micronized and pulverized together.

[0048] The coarse powder of 500g yew bark and root and 100g salt coarse powder (the weight ratio of medicine and solid micronization auxiliary agent is about 100:20) are passed through 60 mesh sieves respectively, and after mixing, use a jet mill (JGM of Huali Company) -H200 airflow mill) for micronization and pulverization, the pulverization pressure is about 6-8bar, the feed rate is 50━75g / min, and the micronization treatment is performed once. The operation of micronization and crushing is smooth. 588.6 g of micronized drug was obtained, and the yield was 98.1%.

[0049] The particle size distribution of the micronized material was measured with a Malvern particle size analyzer, and the results showed that D(50) was 5.6 μm and D(90) was 12.4 μm.

[0050] Coarse powder of yew stem bark and root is micronized together with mic...

Embodiment 2

[0051] Example 2: Adding solid micronization aids, medicinal talcum powder and coarse powder of yew stem bark and root are micronized and pulverized together.

[0052] The coarse powder of 500g yew stem bark and root and 100g medicinal talcum powder (the weight ratio of medicine and solid micronization auxiliary agent is about 100:20) are respectively passed through a 60 mesh sieve, and after mixing, use a jet mill (Hawley The company's JGM-H200 jet mill) is used for micronization and pulverization, the pulverization pressure is about 6-8bar, the feed rate is 50━75g / min, and the micronization treatment is performed once. The operation of micronization and crushing is smooth. Received 590.4g of micronized drug, the yield was 98.4%.

[0053] The particle size distribution of the micronized material was measured with a Malvern particle size analyzer, and the results showed that D(50) was 5.2 μm and D(90) was 9.2 μm. After micronization, there is no sticking phenomenon in the je...

Embodiment 3

[0054] Embodiment 3: add solid micronization auxiliary agent silicon dioxide and coarse powder of yew stem bark and root to micronize and pulverize together.

[0055] The coarse powder of 500g yew bark and root and 100g silicon dioxide coarse powder (the weight ratio of medicine and solid micronization auxiliary agent is about 100:20) are respectively passed through a 60 mesh sieve, and after mixing, use a jet mill (Hawley Corporation) JGM-H200 jet mill) for micronization and pulverization, the pulverization pressure is about 6-8bar, the feed rate is 50━75g / min, and the micronization treatment is performed once. The operation of micronization and crushing is smooth. Received 589.5 g of micronized drug, the yield was 98.2%.

[0056]The particle size distribution of the micronized material was measured with a Malvern particle size analyzer, and the results showed that D(50) was 5.1 μm and D(90) was 9.0 μm. After micronization, there is no sticking phenomenon in the jet mill ca...

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PUM

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Abstract

The invention relates to Chinese yew micronized particles, a compound for health bath obtained by using micronized Chinese yew particle and a preparation method thereof. The preparation method of the micronized Chinese yew particles comprises the following steps of: mixing Chinese yew bark and / or root and micronized solid auxiliary agent so as to form a solid mixture; and crushing the solid mixture in a micronized manner so as to form mixture particles with particle sizes D(90) being smaller than or equal to 15 microns. According to the micronized method disclosed by the invention, the dissolution rate of effective constituents of Chinese yew bark and root is greatly improved, the utilization ratio of Chinese yew bark and root is greatly improved, the adhesion and blockage conditions in crushing are also reduced, the medicine loss is few, and the crushing efficiency of micronized medicine can be obviously improved.

Description

technical field [0001] The invention relates to yew micronized granules, a composition containing the micronized granules for health-care bathing, a health-care lotion and a preparation method thereof. The micronized granule of the present invention not only greatly improves the dissolution rate of the effective ingredients of the rare yew bark and its root, but also greatly improves the utilization rate of the yew bark and root, and also reduces the sticking and clogging during crushing, It can also significantly improve the pulverization efficiency of micronized drugs. Background technique [0002] The base source of yew is Taxaceae (Taxaceae), a plant of the genus Taxus. There are 4 species and 1 variety in China, namely Chinese yew (Taxus chinensis (Pilger) Rehd.), Northeast yew, Yunnan yew (T.YUENNAN ENSIS CHENG ET L.K.FU), Tibetan yew (T.WALL ICHIANA IUCC) and southern yew (T. CHINENSIS VAR MAIREI (LEMEE ET L'EVL) CHENG ET L.K.FU) (variety), widely distributed in sout...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/13A61K9/14A61K36/481A61P17/04A61P39/00A61P25/20A61P3/10A61P17/00A61P13/12A61K125/00A61K135/00
Inventor 朱乃根
Owner 朱乃根
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