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Nanometer golden flower and preparation method and application of nanometer golden flower

A nano-gold and gold flower technology, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, microcapsules, etc., can solve the problems of complex preparation process of gold nanorods and high preparation conditions, and achieve high yield and easy operation. Simple process and uniform size effect

Inactive Publication Date: 2013-09-04
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the preparation process of gold nanorods is relatively complicated, and the requirements for preparation conditions are relatively high.
The traditional core-shell structure has a hard template core, such as SiO 2 , PS, etc., the retention and metabolism of these nuclei in organisms have to arouse our thinking

Method used

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  • Nanometer golden flower and preparation method and application of nanometer golden flower
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  • Nanometer golden flower and preparation method and application of nanometer golden flower

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Embodiment 1、150

[0030] The preparation of the nano gold flower of embodiment 1,150nm

[0031] (1) Preparation of nano golden flower seed solution

[0032] Small-sized gold nanoparticles (preparation method with reference to literature T.Liu, J.A.Tang, L.Jiang, The enhancement effect of gold nanoparticles as a surface modifier on DNA sensor sensitivity.Biochem.Biophys.Res.Commun.313(2004)3 .) (particle size is about 24nm, the concentration of nano-gold solution is 0.25mM) and the vesicle solution formed by C18N3 (concentration 5mM, pH value 3) are mixed according to the volume ratio 1:5, and stirred overnight at room temperature. This solution is called the seed solution.

[0033] (2) Preparation of nano-gold flower growth solution

[0034] Prepare the mixed solution of chloroauric acid and C18N3, the steps are as follows: prepare 100mL of C18N3 aqueous solution, which contains chloroauric acid (HAuCl 4 4H 2 O), and the mol ratio of C18N3 and chloroauric acid is 1.5:1. Place the mixed sol...

Embodiment 2、100

[0039] The preparation of embodiment 2, 100nm nano gold flower

[0040] (1) Preparation of nano golden flower seed solution

[0041] With the step in the step (1) of embodiment 1

[0042] (2) Preparation of nano-gold flower growth solution

[0043] Prepare the mixed solution of chloroauric acid and C18N3, the steps are as follows: mix 100mL of C18N3 and chloroauric acid (HAuCl 4 4H 2 O) mixed solution, wherein C18N3 and chloroauric acid (HAuCl 4 4H 2 O) in a molar ratio of 2:1. Place the mixed solution in an ultrasonic bath at room temperature until C18N3 is completely dispersed in water. This solution is referred to as growth solution in the following examples.

[0044] (3) Preparation of 100nm nano gold flowers

[0045] Same as step (3) of Example 1, wherein the growth liquid of the nano-golden flower is the growth liquid in step (2) of this embodiment, and the reducing agent is hydroxylamine hydrochloride.

[0046] (4) After the reaction is completed, the product is ...

Embodiment 3

[0047] The temperature rise experiment of the nano gold flower prepared by embodiment 3, embodiment 1

[0048] The gold nanoparticles prepared in Example 1 were dispersed in PBS solution, the concentrations were 0 mg / mL, 0.4 mg / mL, 0.6 mg / mL, 1 mg / mL and 2 mg / mL. Take 10 μL of each concentration of golden flower nanometer and place it in a 96-well plate containing 100 μL PBS solution, and then use a power density of 9W cm -2 , a laser with a wavelength of 808nm is used as a light source, and the temperature of each measurement hole is monitored with an infrared temperature measuring gun at regular intervals, and the data is recorded.

[0049] The variation curve of temperature with time during the different concentrations of the nano gold flowers prepared in embodiment 1 is as follows: image 3 shown. Depend on image 3 It can be seen that the temperature of the gold nanoparticles prepared in Example 1 can rise rapidly within 3 minutes after laser irradiation, and the tempe...

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Abstract

The invention discloses a nanometer golden flower which has a photothermal effect and can kill cancer cells, and a preparation method and application of the nanometer golden flower. The preparation method of the nanometer golden flower includes the steps that (1) nanogold is mixed with a Cl8N3 vesicle solution to form a nanogold / Cl8N3 vesicle compound solution, and (2) the nanogold / Cl8N3 vesicle compound solution serves as seeds and is added to a mixing solution of HAuCl4 and C18N3, reducing agent is added after the solution is evenly mixed, and chloroauric acid is enabled to carry out a reduction reaction to obtain the nanometer golden flower. The nanometer golden flower can absorb light in a near-infrared area, then rapidly converts the light into heat, rapid temperature rise is caused on the surfaces of nano-particles, and therefore the nanometer golden flower can serves as a photo-thermal agent to be used for photo-thermal treatment of tumors.

Description

technical field [0001] The invention relates to a nano gold flower and its preparation method and application. Background technique [0002] In recent years, nanomaterials as medicine is a very important application in the field of nanotechnology. Among these applications, the use of nanomaterials to absorb light in the near-infrared region for photothermal therapy of cancer has received extensive attention from researchers. Compared with traditional surgical therapy, photothermal therapy has the advantages of easy operation, rapid recovery after treatment, less side effects and shorter treatment cycle. [0003] Nanomaterials with plasmonic properties, especially nanomaterials that can convert light in the near-infrared region into heat, have become good choices for photothermal agents. This kind of nanomaterials can adjust its absorption spectrum by adjusting its size, morphology and composition, among which gold, silver and palladium nanomaterials are more studied. Nano...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24A61K41/00A61K9/51A61P35/00
Inventor 江龙韩静李津如贾文峰
Owner INST OF CHEM CHINESE ACAD OF SCI
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