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A kind of hemostatic sponge and preparation method thereof

A technology of hemostatic sponge and hemostatic material, which is applied in the field of hemostatic sponge and its preparation, can solve the problems of low water absorption of modified starch and unstable preparations, and achieve the effects of improving water absorption performance, stable preparations, and benefiting industrial production

Active Publication Date: 2016-08-10
江苏德威兰医疗器械股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] An object of the present invention is to provide a new hemostatic sponge, which has good water absorption, safety, and stable performance, and overcomes the shortcomings of low water absorption of modified starch and unstable preparations in the prior art.

Method used

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  • A kind of hemostatic sponge and preparation method thereof
  • A kind of hemostatic sponge and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Hydroxypropyl distarch phosphate is subjected to etherification, crosslinking and esterification with chemical reagents such as propylene oxide and phosphoric acid to make new modified starch, and then the modified starch slurry (ice bath) is placed in ultrasonic In the cell pulverizer, use 450w power to act for 3min (act for 2s and rest for 2s). Wash with alcohol, dry, and freeze-dry for 15 hours at -45° C. under a vacuum of 15 Pa to obtain a hemostatic sponge 1 .

Embodiment 2

[0033] The hydroxypropyl distarch phosphate slurry (ice bath) was placed in an ultrasonic cell pulverizer, and acted on with 450w power for 3min (acting for 2s and resting for 2s). Wash with alcohol, dry, and then undergo etherification, cross-linking, and esterification with chemical reagents such as propylene oxide and phosphoric acid to make new modified starch. Freeze-dry at -45°C and vacuum at 15 Pa for 15 hour, get the hemostatic sponge 2.

Embodiment 3

[0035] The hydroxyethyl starch is subjected to etherification, cross-linking and esterification with chemical reagents such as propylene oxide and phosphoric acid to make a new modified starch, and then the modified starch slurry (ice bath) is placed in an ultrasonic cell pulverizer In the middle, use 450w power to act for 3min (act for 2s and rest for 2s). Wash with alcohol, dry, and freeze-dry for 15 hours at -45° C. under a vacuum of 15 Pa to obtain a hemostatic sponge 3 .

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Abstract

The invention relates to hemostatic sponge and applications of the hemostatic sponge. The hemostatic sponge is prepared from the modified starch in the prior art, which is re-modified and subjected to ultrasonic treatment. The hemostatic sponge is excellent in water absorption effect, safe and stable, and is biocompatible and can be directly applied to bloody wound surfaces.

Description

technical field [0001] The invention relates to a hemostatic sponge and a preparation method thereof, in particular to a biocompatible hemostatic sponge which can be directly used on bloody wounds and a preparation method thereof. Background technique [0002] Bleeding is the most likely phenomenon in accidents and medical treatment. A large amount of bleeding will endanger human life. Therefore, it is necessary to stop bleeding in time for bleeding wounds. [0003] With the development of medicine, there are many kinds of hemostatic materials. In terms of biocompatibility, commonly used biocompatible hemostatic materials include: absorbable gelatin sponge, collagen sponge and other gelatin hemostatic materials; oxidized cellulose, oxidized regeneration Cellulose hemostatic materials; chitosan / chitin, starch polysaccharides and other natural biopolysaccharide hemostatic materials, etc. [0004] The content of the present invention relates to the hemostatic material of starc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/28C08B31/02C08B31/08C08B31/00A61L15/28A61L31/04
Inventor 刘泊志
Owner 江苏德威兰医疗器械股份有限公司
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