32results about How to "Preparation safety" patented technology

The present invention relates to hemostasis starch and applications thereof, wherein modified starch in the existing technology is subjected to denaturation again, and then is subjected to a ray irradiation treatment to finally prepare the hemostasis starch. The hemostasis starch has characteristics of excellent water absorption effect, safety, stability and biocompatibility, and can be directly used for a wound surface having blood.

The invention relates to hemostatic sponge and applications of the hemostatic sponge. The hemostatic sponge is prepared from the modified starch in the prior art, which is re-modified and subjected to ultrasonic treatment. The hemostatic sponge is excellent in water absorption effect, safe and stable, and is biocompatible and can be directly applied to bloody wound surfaces.

The present invention relates to hemostasis starch and applications thereof, wherein modified starch in the existing technology is subjected to denaturation again, and then is subjected to an ultrasonic treatment to finally prepare the hemostasis starch. The hemostasis starch has characteristics of excellent water absorption effect, safety, stability and biocompatibility, and can be directly used for a wound surface having blood.

The invention relates to a bleeding stopping starch and an application thereof. The bleeding stopping starch is prepared through redenaturation of denaturated starch in the prior art, and microwave processing. The bleeding stopping starch has the advantages of excellent water absorption effect, safety and stability, has biocompatibility, and can be directly applied to bleeding wounds.

The invention discloses a tripterygium wilfordii plastic for treating rheumatoid arthritis and a preparation method thereof. The tripterygium wilfordii plastic of the invention comprises the following components on a basis of 100 parts by weight: 0.5-1.5 parts of tripterygium wilfordii extract; 0.1-10 parts of film forming materials; 2-8 parts of plasticizers; 16-25 parts of solvents; 0.1-1 part of pH adjusting agents; and the balance of water. The tripterygium wilfordii plastic of the invention can be used for treating rheumatoid arthritis, and is safe, lasting, and stable.

A freeze-dried VD2 calcium pectate cream is prepared from VD2 calcium pectate, the oil for injection, stabilizer, emulsifier, pH regulator, freeze-drying protector, antiseptic and the water for injection. Its preparing process is also disclosed.

The present invention relates to hemostasis starch and applications thereof, wherein modified starch in the existing technology is subjected to denaturation again, and then is subjected to a heat stirring treatment to finally prepare the hemostasis starch. The hemostasis starch has characteristics of excellent water absorption effect, safety, stability and biocompatibility, and can be directly used for wound surface having blood.

The invention relates to a traditional Chinese medicine recipe for reducing weight, lipid and blood fat, a preparation, a preparation method and application. The traditional Chinese medicine recipe comprises the following components in parts by weight: 1-5 parts of lotus leaves, 1-5 parts of dogbane leaves, 1-2 parts of rose flowers, 1-3 parts of rheum officinale, and 1-3 parts of honey-fried licorice roots. According to the traditional Chinese medicine recipe and the preparation, the lotus leaves are used for clearing heat, drying dampness, burning fat and losing weight; the rheum officinaleis cooperatively used for breaking stagnation, purging heat toxin, promoting the circulation of extravasated blood, softening hardness to dissipate stagnation, strengthening elimination of stubborn phlegm and dead blood, reducing blood fat, relaxing bowels and burning fat; the dogbane leaves are used for reducing blood pressure, burning fat, clearing liver fire and dredging stasis to benefiting the pivot of qi; the rose flowers are used for cooling blood, promoting blood circulation, removing toxicity, relieving dyspepsia, regulating the liver, calming the nerves, removing stasis in the intestines and the stomach, clearing the intestines, refreshing the stomach, expelling toxin and lightening the body; the honey-fried licorice roots have the functions of tonifying qi and middle warmer, clearing away heat and toxic materials, relieving spasm and pain and relieving drug properties; and the components of the recipe are harmonized, so the heart is protected from being injured by the medicines, and the purposes of losing weight and reducing fat are achieved.

The invention discloses a methylsulfonic acid pridinol oral disintegrating tablet and a preparation method thereof, wherein the oral disintegrating tablet comprises the following components by mass percentage: 2 to 8 percent of methylsulfonic acid pridinol, 40 to 80 percent of filler, 5 to 20 percent of disintegrant, 5 to 30 percent of effervescent agent, 1 to 5 percent of lubricant and 0.5 to 5 percent of flavoring agent. The methylsulfonic acid pridinol oral disintegrating tablet can be quickly disintegrated in mouth cavity and quickly absorbed, and takes effect quickly, has small first-passeffect on liver, high bioavailability, low acrimony to gastrointestinal tract, convenient taking and good taste, and is particularly suitable for the old, children and patients with difficult swallowing or inconvenient drinking of water, or in operation or coma; and the oral disintegrating tablet is prepared by adopting a method of wet granulation and compression or a method of direct compressionof powder, has simple production technique, low cost, easily-controlled quality, and stability, safety and effectiveness of the preparation, is suitable for large-scale industrial production and haswide market prospect.

The invention discloses an amphotericin B cream and a preparation method thereof; the technical scheme is as follows: the cream is composed of an amphotericin B, a solvent or cosolvent, an oil phase matrix, a transdermal enhancer, an emulsifier, a preservative, a humectant, a defoamer and the like. The preparation process comprises the following steps: 1, mixing the oil phase matrix, an oil-soluble emulsifier and the defoamer, heating and melting in water bath to prepare an oil phase; 2, putting a water-soluble emulsifier, the preservative and the humectant into a proper amount of purified water, putting into the water bath, stirring to uniformly dissolve the water-soluble emulsifier, the preservative and the humectant to prepare a water phase; 3, taking the solvent or the cosolvent, adding the amphotericin B bulk drug, stirring to uniformly dissolve the amphotericin B bulk drug; 4, mixing the water phase with the oil phase while stirring, adding an amphotericin B liquid, supplementing the purified water to the total; stirring for emulsifying, standing at room temperature, detecting the content of the amphotericin B, computing, filling, and packaging to obtain the finished product. The bad water-solubility of the amphotericin B is overcome by using the preparation method which is simple in process and good in compliance. The serious toxic side effect in injection of the amphotericin B is overcome by the externally applying the amphotericin B cream; a safe, effective and stable preparation is provided for a patient.

The invention discloses a compound nasal preparation for the treatment of allergic rhinitis, which is composed of an anti-M cholinergic drug, an antihistamine drug, a hormone, a local vasoconstriction drug and the rest amount of medicine auxiliary materials for compatibility. The invention obtains the compound nasal preparation which has a reasonable pharmaceutical combined formula and can produce the great synergy by screening, the compound nasal preparation is safe, effective, rapid in action and can comprehensively control and fundamentally improve the symptoms of the allergic rhinitis, as well as solve the technical problem of fundamentally improving or curing the allergic rhinitis.

The invention discloses compound capsaicin sanitizer which is characterized by being prepared from 1.0-2.0 g of capsaicin, 20-30 g of hedyotis diffusa, 10-20 g of artemisia argyi, 10-20 g of dandelion and 10-20 g of common anemarrhena rhizome. The compound capsaicin sanitizer is prepared in steps as follows: hedyotis diffusa, artemisia argyi, dandelion and common anemarrhena rhizome are ground into fine powder, mixed, subjected to water bath decoction at the temperature of 90-95 DEG C and filtered by a net with 100 meshes, capsaicin is added to the mixture and uniformly mixed when a solution is cooled to the temperature of 40-50 DEG C, and the compound capsaicin sanitizer is obtained. The compound capsaicin sanitizer can be prepared to form dosage forms of emulsifier, spray, aerosol, gel, water aqua, oil, tablets and the like and can be used for food sterilization. The compound capsaicin sanitizer has the benefits that the compound capsaicin sanitizer is high-effect, broad-spectrum, safe and non-toxic.

The invention relates to a method for preparing a spray for preventing emerging respiratory tract infectious diseases, and belongs to the technical field of preparation methods of Chinese medicinal preparations. The preparation method comprises the following steps of: performing water boiling and alcohol precipitation on indigowoad root and astragalus, mixing, filtering, evaporating rotatably and concentrating; adding water into halloysit for dipping, adding indigowoad root extract and astragalus extract, and stirring fully; putting the liquid into a colloid mill for grinding and refining, and sieving with a 325-mesh sieve; stirring the sieved liquid under heating, cooling to room temperature, adding sodium carboxymethylcellulose and sodium benzoate, and stirring fully to form suspension; and adding the suspension into a medicinal plastic bottle with a quantitative spray pump to obtain the spray for preventing the respiratory tract infectious diseases. The spray prepared by the method has the advantages that the spray does not become invalid due to the cirus variation, does not produce drug resistance, prevents unpredictable new respiratory infectious disease, effectively cuts off the propagation path, and protects the susceptible population.

The invention discloses a tripterygium wilfordii plastic for treating rheumatoid arthritis and a preparation method thereof. The tripterygium wilfordii plastic of the invention comprises the following components on a basis of 100 parts by weight: 0.5-1.5 parts of tripterygium wilfordii extract; 0.1-10 parts of film forming materials; 2-8 parts of plasticizers; 16-25 parts of solvents; 0.1-1 part of pH adjusting agents; and the balance of water. The tripterygium wilfordii plastic of the invention can be used for treating rheumatoid arthritis, and is safe, lasting, and stable.

The invention belongs to the field of hemostasis sponges, and relates to a hemostasis sponge and applications thereof. In order to solve the problem of poor water absorption of the hemostasis sponge in the prior art, the technical scheme of the present invention is that various modified starches in the existing technology are adopted, and sodium hydroxide, the modified starch and alcohol are mixed, and are subjected to cross-linking, etherification and other steps to prepare the high water absorption hemostasis sponge. The hemostasis sponge has characteristics of excellent water absorption effect, safety, stability and biocompatibility, and can be directly used for wound surface having blood.

The present invention relates to hemostasis starch and applications thereof, wherein modified starch in the existing technology is subjected to denaturation again, and then is subjected to a ray irradiation treatment to finally prepare the hemostasis starch. The hemostasis starch has characteristics of excellent water absorption effect, safety, stability and biocompatibility, and can be directly used for a wound surface having blood.

The present invention relates to hemostasis starch and applications thereof, wherein modified starch in the existing technology is subjected to denaturation again, and then is subjected to an ultrasonic treatment to finally prepare the hemostasis starch. The hemostasis starch has characteristics of excellent water absorption effect, safety, stability and biocompatibility, and can be directly used for a wound surface having blood.

The invention provides a method for preparing a medicine for treating cough. The method comprises the following steps: weighing 15g of garden balsam stem, 25g of tendril-leaved fritillary bulb, 20g of raw liquorice, 15g of honeysuckle, 12g of ainsliaea, 15g of bitter apricot kernel, 10g of radix ophiopogonis and 15g of pseudo-ginseng; adding water the weight of which is 5 times of the total weight of the medicinal materials to wash the medicinal materials; standing for 1-2 hours, and putting into an evaporator; drying by distillation, crushing, and uniformly mixing; filtering through a 180-mesh screen. The medicine is prepared from natural Chinese medicines, is low in price, mild in property, stable in preparation, safe and reliable, does not have adverse response, is mainly used for treating dryness-heat cough and chronic coughing caused by internal causes, and has main effects of nourishing lung, removing evilness of dryness-heat, astringing and relieving cough.

The invention belongs to the field of hemostatic starch, and relates to a hemostatic starch and an application thereof. In order to solve the problem of poor water absorption of hemostatic starch in the prior art, the technical solution of the present invention is to mix various modified starches in the prior art with sodium hydroxide, modified starch and alcohol, and through steps such as crosslinking and etherification to finally Preparation of highly water-absorbing hemostatic starch. The hemostatic starch has excellent water absorption effect, is safe and stable, and is a biocompatible hemostatic starch that can be directly used on bloody wounds.

The invention discloses an adjuvant-free single-dose HBsAg nanogel vaccine and a preparation method thereof. The preparation method of the adjuvant-free single-dose HBsAg nanogel vaccine comprises the following step: under a constant-temperature stirring condition, mixing CS, HBsAg and a gamma-PGA solution step by step to prepare the positive-charge or negative-charge adjuvant-free single-dose HBsAg nanogel vaccine. The positive-charge HBsAg nanogel vaccine can obtain effective antibody expression only by single-dose injection, so that the immunity of cells is enhanced, the compliance of a vaccinator can be better improved, and general implementation of HBV prevention is guaranteed. The adjuvant-free single-dose HBsAg nanogel vaccine can induce formation of immunological memory to perform long-acting immunity protection on the vaccinator. The negative-charge HBsAg nanogel vaccine has no obvious generation of antibodies through single-dose injection, but when applied in combination with the positive-charge HBsAg nanogel vaccine, can obtain stronger cell immunity, and can better perform long-acting immunity protection on HBV.

The invention provides an injection containing oridonium diterpenoids or derivatives thereof and β-cyclodextrin or derivatives thereof with anticancer effect. The diterpenoids of Rubescens japonicus are poorly soluble drugs, and making such compounds into cyclodextrin inclusion complexes can improve the solubility of such drugs, and then produce aqueous injections and frozen preparations of diterpenoids of Rubescens japonicus according to pharmaceutical preparations. Dry powder injection. The present invention can remarkably improve the solubility of this type of compound in water, making its solubility reach 8-16 mg / ml on average, and overcomes the shortcomings of traditional intravenous administration that patients cannot tolerate local stimulation and have to interrupt treatment; the stability of the drug of the present invention Good reproducibility of the process; the medicine of the present invention is used for the treatment of malignant solid tumors and leukemia including liver cancer, esophageal cancer, gastric cancer, bladder cancer, and colorectal cancer, and can better exert the therapeutic effect of this type of compound and improve patient compliance.

The invention discloses an anti-fatigue traditional Chinese medicine preparation containing herba euonymi. The anti-fatigue traditional Chinese medicine preparation is prepared from the following ingredients: the herba euonymi, radix astragali seu hedysari, poria cocos, gordon euryale seeds, licorice root and radix ginseng. The anti-fatigue traditional Chinese medicine preparation containing herba euonymi utilizes the herba euonymi as a monarch drug, and the radix astragali seu hedysari, the tuckahoe, the gordon euryale seeds, the licorice root and the radix ginseng as adjuvant drugs, and has the efficacies of effectively and rapidly eliminating fatigue and continously resisting fatigue for a long time.

The invention provides a novel preparation for treating triple-negative breast cancer, and belongs to the field of anti-tumor preparations. The preparation of the invention is prepared from an miR-200c-3p agonist as the active ingredient and a pharmaceutically acceptable carrier. The preparation provided by the invention has a very obvious inhibitory effect on the proliferation, migration and invasion of the triple-negative breast cancer, and significantly inhibits growth of transplanted tumors of the triple-negative breast cancer in mice in vivo, thereby filling the gap of a targeted preparation of the triple-negative breast cancer.

The invention relates to hemostatic sponge and applications of the hemostatic sponge. The hemostatic sponge is prepared from the modified starch in the prior art, which is re-modified and subjected to ray irradiation. The hemostatic sponge is excellent in water absorption effect, safe and stable, and is biocompatible and can be directly applied to bloody wound surfaces.

The invention provides an inhalation umeclidinium bromide solution, a preparation method and application thereof, the inhalation solution comprises an active substance, a solvent and auxiliary materials, the single dose specification of the inhalation solution is 1-5ml, and the active substance in the single dose specification is 20-100 micrograms of umeclidinium bromide; the solvent is sterile injection water; the auxiliary materials comprise an isoosmotic adjusting agent and a pH adjusting agent; the adding amount of the isoosmotic adjusting agent is such that the inhalation solution has a weight gram molecule osmotic concentration of 240-400mOsmol / kg; the pH regulator is added so that the pH value of the inhalation solution preparation is 4.0-6.0. The device for combining the ullidinium bromide solution for inhalation with an atomized aerosol can provide a medicine dosage form of the ullidinium bromide for inhalation, which is convenient to use, safe, effective and good in stability, and an administration system.

The invention relates to a method for preparing a spray for preventing emerging respiratory tract infectious diseases, and belongs to the technical field of preparation methods of Chinese medicinal preparations. The preparation method comprises the following steps of: performing water boiling and alcohol precipitation on indigowoad root and astragalus, mixing, filtering, evaporating rotatably and concentrating; adding water into halloysit for dipping, adding indigowoad root extract and astragalus extract, and stirring fully; putting the liquid into a colloid mill for grinding and refining, and sieving with a 325-mesh sieve; stirring the sieved liquid under heating, cooling to room temperature, adding sodium carboxymethylcellulose and sodium benzoate, and stirring fully to form suspension; and adding the suspension into a medicinal plastic bottle with a quantitative spray pump to obtain the spray for preventing the respiratory tract infectious diseases. The spray prepared by the method has the advantages that the spray is safe, quick-acting and stable, is convenient to use and easy to produce, and is favorable for the medication of a large crowd.

The invention discloses an adjuvant-free single-dose HBsAg nanogel vaccine and a preparation method thereof. The preparation method of the adjuvant-free single-dose HBsAg nanogel vaccine comprises the following step: under a constant-temperature stirring condition, mixing CS, HBsAg and a gamma-PGA solution step by step to prepare the positive-charge or negative-charge adjuvant-free single-dose HBsAg nanogel vaccine. The positive-charge HBsAg nanogel vaccine can obtain effective antibody expression only by single-dose injection, so that the immunity of cells is enhanced, the compliance of a vaccinator can be better improved, and general implementation of HBV prevention is guaranteed. The adjuvant-free single-dose HBsAg nanogel vaccine can induce formation of immunological memory to perform long-acting immunity protection on the vaccinator. The negative-charge HBsAg nanogel vaccine has no obvious generation of antibodies through single-dose injection, but when applied in combination with the positive-charge HBsAg nanogel vaccine, can obtain stronger cell immunity, and can better perform long-acting immunity protection on HBV.