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A kind of hemostatic sponge and preparation method thereof

The technology of hemostatic sponge and modified starch is applied in the field of hemostatic sponge and its preparation, which can solve the problems of low water absorption of modified starch and unstable preparation, and achieve the effects of improving water absorption performance, stable preparation and convenient preparation.

Active Publication Date: 2016-08-10
江苏德威兰医疗器械股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] An object of the present invention is to provide a new hemostatic sponge, which has good water absorption, safety, and stable performance, and overcomes the shortcomings of low water absorption of modified starch and unstable preparations in the prior art.

Method used

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  • A kind of hemostatic sponge and preparation method thereof
  • A kind of hemostatic sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The hydroxypropyl distarch phosphate is etherified, cross-linked, and esterified with chemical reagents such as propylene oxide and phosphoric acid to make new modified starch, and then the modified starch slurry is exposed to X-rays. Irradiate for 12 min, X-ray intensity is 0.8KeV, suction filtered, washed with alcohol, dried, freeze-dried at -45°C and vacuum of 15 Pa for 15 hours to obtain hemostatic sponge 1.

Embodiment 2

[0037] Put the hydroxypropyl distarch phosphate slurry under X-ray irradiation for 12 minutes, the X-ray intensity is 1.5KeV, suction filtered, washed with alcohol, dried, and then etherified and exchanged with chemical reagents such as propylene oxide and phosphoric acid. After multiple denaturation and esterification, a new modified starch is made into a new modified starch, which is freeze-dried at -45°C and a vacuum of 15 Pa for 15 hours to obtain a hemostatic sponge 2.

Embodiment 3

[0039] The hydroxyethyl starch is etherified, cross-linked, and esterified with chemical reagents such as propylene oxide and phosphoric acid to make new modified starch. Then the modified starch slurry is exposed to X-ray irradiation for 8 minutes. The X-ray intensity was 0.8KeV, filtered with suction, washed with alcohol, dried, freeze-dried at -45°C and a vacuum of 15 Pa for 15 hours to obtain a hemostatic sponge 3.

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Abstract

The invention relates to hemostatic sponge and applications of the hemostatic sponge. The hemostatic sponge is prepared from the modified starch in the prior art, which is re-modified and subjected to ray irradiation. The hemostatic sponge is excellent in water absorption effect, safe and stable, and is biocompatible and can be directly applied to bloody wound surfaces.

Description

Technical field [0001] The invention relates to a hemostatic sponge and a preparation method thereof, in particular to a hemostatic sponge that is biocompatible and can be directly used on a bloody wound and a preparation method thereof. Background technique [0002] Bleeding is the most common phenomenon in accidents and medical procedures. A large amount of bleeding can endanger human life and safety, so it is necessary to stop bleeding in time for bleeding wounds. [0003] With the development of medicine, there are many types of hemostatic materials. In terms of biocompatibility, commonly used biocompatible hemostatic materials include: absorbable gelatin sponge, collagen sponge and other gelatin hemostatic materials; oxidized cellulose, oxidized regeneration Cellulose hemostatic materials; natural biological polysaccharide hemostatic materials such as chitosan / chitin, starch polysaccharides, etc. [0004] The content of the present invention relates to a hemostatic material of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/28C08B31/02C08B31/08C08B31/00A61L15/28A61L31/04
Inventor 刘泊志
Owner 江苏德威兰医疗器械股份有限公司
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