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A kind of hemostatic sponge and preparation method thereof

A technology of hemostatic sponge and reactor, which is applied in the field of hemostatic sponge and its preparation, can solve the problems of unstable preparation and low water absorption of modified starch, and achieve the effects of stable preparation, improved water absorption performance, and convenient preparation

Active Publication Date: 2016-08-10
江苏德威兰医疗器械股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] An object of the present invention is to provide a new hemostatic sponge, which has good water absorption, safety, and stable performance, and overcomes the shortcomings of low water absorption of modified starch and unstable preparations in the prior art.

Method used

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  • A kind of hemostatic sponge and preparation method thereof
  • A kind of hemostatic sponge and preparation method thereof
  • A kind of hemostatic sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Screening test of the preferred substance dosage and step parameters of the hemostatic sponge of the present invention

[0048] The selection and consumption of each substance in the reaction are shown in the table below

[0049] Table 1.

[0050]

[0051]

[0052]

[0053]

[0054]

[0055]

[0056]

[0057]

[0058]

[0059] Combinations of the above 1-45 reactants were used to prepare hemostatic sponges 1-45 according to the following method 1:

[0060] Method 1: Put sodium hydroxide, modified starch and alcohol into the reactor, mix and stir to dissolve completely;

[0061] Add cross-linking agent to the reactor, react for 50min;

[0062]Introduce nitrogen gas into the reactor for 5 minutes, then add etherifying agent for reaction, and infuse nitrogen gas for 5 minutes again, seal the reactor, heat the water area to 40°C, and stir for 2 hours;

[0063] Neutralize the above reactant to pH6.5 with dilute acid;

[0064] Suction ...

Embodiment 2

[0071] Embodiment 2 control group experimental design

[0072] According to the methods of Examples 1, 3, 4, and 5 of the patent cn200710199682.3, the hemostatic sponges A, C, D, and E were respectively prepared as the control group.

Embodiment 3

[0073] The detection of the water absorption rate of embodiment 3 hemostatic sponge and water absorption rate

[0074] The water absorption rate of the sponge is determined by centrifugation, that is, about 0.025g of the sponge is placed in 2ml of water, balanced for 10 minutes, then placed in a centrifuge, and taken out after centrifugation at 500rpm for 10 minutes, and the amount of residual liquid is calculated by weighing. Each sample is tested for 6 Times to average.

[0075] The water absorption rate of the sponge was observed by the OCA40Micro video contact angle measuring instrument from Dataphysics, Germany.

[0076] Experimental results: the comparison of the water absorption ratio and water absorption rate of the 90 kinds of hemostatic starches prepared by the method of Example 1 and the hemostatic sponges A, C, D, and E obtained by the control group of Example 2 are shown in the following table:

[0077] Table 2

[0078]

[0079]

[0080]

[0081]

[...

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PUM

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Abstract

The invention belongs to the field of hemostasis sponges, and relates to a hemostasis sponge and applications thereof. In order to solve the problem of poor water absorption of the hemostasis sponge in the prior art, the technical scheme of the present invention is that various modified starches in the existing technology are adopted, and sodium hydroxide, the modified starch and alcohol are mixed, and are subjected to cross-linking, etherification and other steps to prepare the high water absorption hemostasis sponge. The hemostasis sponge has characteristics of excellent water absorption effect, safety, stability and biocompatibility, and can be directly used for wound surface having blood.

Description

technical field [0001] The invention relates to a hemostatic sponge and a preparation method thereof, in particular to a biocompatible hemostatic sponge which can be directly used on bloody wounds and a preparation method thereof. Background technique [0002] Bleeding is the most likely phenomenon in accidents and medical treatment. A large amount of bleeding will endanger human life. Therefore, it is necessary to stop bleeding in time for bleeding wounds. [0003] With the development of medicine, there are many kinds of hemostatic materials. In terms of biocompatibility, commonly used biocompatible hemostatic materials include: absorbable gelatin sponge, collagen sponge and other gelatin hemostatic materials; oxidized cellulose, oxidized regeneration Cellulose hemostatic materials; chitosan / chitin, starch polysaccharides and other natural biopolysaccharide hemostatic materials, etc. [0004] The content of the present invention relates to the hemostatic material of starc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/28C08B31/08C08J3/24A61L15/28A61L31/04
Inventor 刘泊志
Owner 江苏德威兰医疗器械股份有限公司
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