Tripterygium wilfordii plastic for treating rheumatoid arthritis and preparation method thereof

A technology of rheumatoid and Tripterygium wilfordii, which is applied in the field of transdermal drug delivery preparations of traditional Chinese medicine, can solve the problems of no coating agent, achieve good penetration effect, reduce toxicity, and increase solubility

Inactive Publication Date: 2014-07-09
ZHEJIANG UNIV OF TECH +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] There are many research reports on applying Tripterygium wilfordii extract to coating agents at present, such as "The Development of Compound Tripterygium wilfordii varnish" by Peng Song, which uses triptolide as the efficacy index, and Meng Lijun et al. The Preparation and Stability of Rattan Film-coating Agents", using tripterygium total alkaloids, triptolide, triptolide, tripterygium total glycosides, etc. film coating agent

Method used

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  • Tripterygium wilfordii plastic for treating rheumatoid arthritis and preparation method thereof
  • Tripterygium wilfordii plastic for treating rheumatoid arthritis and preparation method thereof
  • Tripterygium wilfordii plastic for treating rheumatoid arthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 Tripterygium wilfordii film-coating agent

[0036] The proportion of each material is as follows:

[0037] Tripterygium wilfordii extract

1g

Polyvinyl alcohol 124

5g

Propylene Glycol

2g

ethanol

25g

[0038] Triethanolamine

0.7g

Add distilled water to

100g

[0039] Preparation:

[0040] Weigh polyvinyl alcohol 124 according to the prescription amount, make it 10% concentration with distilled water, seal it, soak it in cold water for 12 hours, swell it in a water bath at 80°C for 2 hours, take it out and let it cool for later use. Add the prescribed amount of propylene glycol solution to the polyvinyl alcohol 124 solution under stirring, and stir evenly. Dissolve the prescription amount of Tripterygium wilfordii extract in the prescription amount of ethanol, slowly add it to the above matrix, and stir while adding to prevent the precipitation of polyvinyl ...

Embodiment 2

[0041] The preparation of embodiment 2 Tripterygium wilfordii film-coating agent

[0042] The proportion of each material is as follows:

[0043] Tripterygium wilfordii extract

0.5g

Polyvinyl alcohol 1788

10g

Glycerol

6g

ethanol

16g

Ammonia

0.5g

Add distilled water to

100g

[0044] Preparation:

[0045] Weigh polyvinyl alcohol 1788 according to the prescription amount, make it 20% concentration with distilled water, seal it, soak it in cold water for 18 hours, swell it in a water bath at 80°C for 3 hours, take it out and let it cool for later use. Add the prescribed amount of glycerin solution to the polyvinyl alcohol 1788 solution under stirring, and stir evenly. Dissolve the prescription amount of Tripterygium wilfordii extract in the prescription amount of ethanol, slowly add it to the above matrix, and stir while adding to prevent the precipitation of polyvinyl alcohol 1788. Finally, add distill...

Embodiment 3

[0046] The preparation of embodiment 3 Tripterygium wilfordii film-coating agent

[0047] The proportion of each material is as follows:

[0048] Tripterygium wilfordii extract

1.5g

Carbomer 940

0.1g

Diethyl phthalate

4g

ethanol

20g

[0049] Sodium citrate

0.3g

Add distilled water to

100g

[0050] Preparation:

[0051] Weigh the carbomer according to the prescription amount, make it into 0.2% concentration with distilled water, seal it, soak it in cold water for 12 hours, swell it in a water bath at 90°C for 2 hours, take it out and let it cool for later use. Add the prescribed amount of diethyl phthalate solution to the carbomer solution under stirring, and stir evenly. Dissolve the prescription amount of Tripterygium wilfordii extract in the prescription amount of ethanol, slowly add it to the above matrix, and stir while adding. Finally, distilled water was added to a sufficient amount,...

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Abstract

The invention discloses a tripterygium wilfordii plastic for treating rheumatoid arthritis and a preparation method thereof. The tripterygium wilfordii plastic of the invention comprises the following components on a basis of 100 parts by weight: 0.5-1.5 parts of tripterygium wilfordii extract; 0.1-10 parts of film forming materials; 2-8 parts of plasticizers; 16-25 parts of solvents; 0.1-1 part of pH adjusting agents; and the balance of water. The tripterygium wilfordii plastic of the invention can be used for treating rheumatoid arthritis, and is safe, lasting, and stable.

Description

technical field [0001] The invention belongs to the field of transdermal drug delivery preparations of traditional Chinese medicine, and relates to a tripterygium wilfordii coating agent for treating rheumatoid arthritis and a preparation method thereof, and the tripterygium wilfordii coating agent of the invention can be used It is used to treat or relieve various symptoms caused by rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease mainly characterized by multiple and symmetrical proliferative synovitis. It is one of the main causes of loss of labor force and disability, and ranks among the top ten chronic diseases in China. [0003] Tripterygium wilfordii, as the main herbal drug for the treatment of RA, has received extensive attention in recent years. Tripterygium wilfordii is the root, leaf and flower of the Euonymus plant Tripterygium wilfordii, which has the functions of dispelling wind and dampnes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61K31/56A61K9/70A61P19/02A61P29/00
Inventor 马凤森周密方剑乔方多凤方芳
Owner ZHEJIANG UNIV OF TECH
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