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Bauhinia championii n-butyl alcohol extract as well as preparation method and application thereof

A technology of n-butanol and Longsudan, applied in the field of ethyl acetate extract of Longsudan, achieves the effects of clear efficacy, controllable quality and stable preparation method

Active Publication Date: 2013-11-27
广州高泰生物科技有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0003] Literature HONG Z F, ZHENG H Y, XU W, et al. Study on resistinflammation and analgesic effect of Kangmeifu Burns Ointment (KBO) [J]. Chin J Tradit Med Sci Technol (Chinese Traditional Medicine Science and Technology), 2007,14(4):261 -262.HONG Z F,ZHENG H Y,WANG R G,et al.Study on antibacterial activity of Kangmeifu Burns Ointment(KBO)[J].Chin J Microecol(Chinese Journal of Microecology),2007,19(2):177- 178.] It is reported that the flavonoids in Astragalus have analgesic and anti-inflammatory effects. This document only mentions that the crude total flavonoids have analgesic and anti-inflammatory effects, and does not involve specific compounds

Method used

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  • Bauhinia championii n-butyl alcohol extract as well as preparation method and application thereof
  • Bauhinia championii n-butyl alcohol extract as well as preparation method and application thereof
  • Bauhinia championii n-butyl alcohol extract as well as preparation method and application thereof

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Experimental program
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Embodiment 1

[0038] Example 1 Separation and purification of the components of the ethyl acetate part and n-butanol part of Astragalus

[0039] 1. Extraction and separation

[0040] Take 1000g of Longxu Teng medicinal material, add 80% ethanol, heat and reflux extract three times, each time for 1.5h, filter, combine the ethanol solution, recover the ethanol until it has no alcohol smell, and obtain the alcohol extraction extract. Add 2000ml of water to suspend the extract, add petroleum ether to extract 5 times, 1000ml / time, combine the petroleum ether extract, recycle, and obtain an oily substance; add chloroform to the water layer and extract 5 times, 1000ml / time, combine the chloroform extract, Recover and dry to obtain extract; Add ethyl acetate to extract the water layer 5 times, 1000ml / time, combine ethyl acetate extract, recover, dry to obtain extract; Add n-butanol to extract 5 times, 1000ml Each time, the n-butanol extract was combined, recovered, dried to obtain an extract.

[...

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Abstract

The invention provides a bauhinia championii n-butyl alcohol extract. The weight percent content of Beta-sitosterol contained in the extract cannot be less than 0.1%. The invention further provides a preparation method and an application of the bauhinia championii n-butyl alcohol extract. The bauhinia championii n-butyl alcohol is used for treating chronic infectious arthritis, and is definite in efficacy, controllable in quality and stable in preparation method, thereby being suitable for mass production. Thus, a new clinical selection is provided.

Description

technical field [0001] The invention relates to ethyl acetate extract and n-butanol extract of astragalus and its preparation method and application, which belong to the field of medicine. Background technique [0002] Longxuteng is the vine of Bauhinia championii Benth., also known as Jiulongteng and Meihuarugudan. It is mainly distributed in Fujian, Jiangxi, Guangxi, Zhejiang, etc., and has the effect of dispelling rheumatism and promoting blood qi. Modern pharmacological studies have proved that the active ingredients of Astragalus chinensis have the functions of expelling wind and dampness, promoting blood circulation and relieving pain, invigorating spleen and regulating qi, and are used to treat rheumatoid arthritis, waist and leg pain, bruises, stomach pain, and malnutrition in children. According to the prescription of Huang Jingang, a well-known doctor in southern Fujian, Kangmeifu Burn Ointment with Longxuteng as the main ingredient has a good clinical effect on tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K31/352A61P29/00A61P19/02
Inventor 徐伟陈立典褚克丹李煌郑海音张玉琴
Owner 广州高泰生物科技有限公司
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