Method for preparing deuterated chloroform by using hexachloroacetone as intermediate

Abstract

The invention provides a method for preparing deuterated chloroform by using hexachloroacetone as an intermediate. The method comprises the following steps: step 1, producing hexachloroacetone by monochloroacetone and / or polychlorinated acetone raw material liquid, and comprising the steps of raw material liquid pre-treatment, chlorination catalytic reaction and reaction product purification; step 2, producing deuterated chloroform by taking hexachloroacetone as raw material, and comprising the steps of hydrolytic catalytic reaction and reaction product purification. The method solves the problem of the disposing of waste material produced during the production of monochloroacetone, trichloroacetone and the like, and is in favor of relieving the environment burden; common cheap chemical is used as catalytic agent, the side reaction is less, the reaction product is easy to separate, and the content of the produced pollutant is greatly lowered. Through the utilization of the polarization and weakening effects of connecting bond of the carbonyl carbon of the hexachloroacetone and trichloromethyl, the carbonyl carbon of the hexachloroacetone and trichloromethyl are hydrolyzed in an alkalescence condition to produce deuterated chloroform, and the reaction product is CO2 that can be discharged into air directly. The method has important social benefits and economic benefits.

Description

technical field [0001] The invention relates to a preparation method of hexachloroacetone and deuterated chloroform, in particular to a method for preparing deuterated chloroform with hexachloroacetone as an intermediate. Background technique [0002] Monochloroacetone and trichloroacetone are commonly used chemical raw materials. The reaction process is that the H atom at a specific position in the acetone structure is replaced by a Cl atom under the catalysis of a catalyst with a specific structure to generate the desired product. However, in this process, side reactions will occur, generating non-ideal products such as dichloroacetone, tetrachloroacetone, and pentachloroacetone. After the ideal products are separated in post-treatment, the postpartum waste liquid becomes industrial waste. These polychlorinated The direct discharge of post-production waste will cause serious environmental pollution, and it has no use value itself. [0003] Hexachloroacetone is also a comm...

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Problems solved by technology

[0008]Deuterated chloroform is the most commonly used solvent for nuclear magnetic resonance examinations. Now the deuterated chloroform used in China mainly depends on imports. Imports have high prices and inconvenient transportation. Unfavorable factors, if it can be localized on a large scale, it will bring great significance

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