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Application of sterol phenolic acid esters in the preparation of breast cancer drugs

A technology of sterol phenolic acid ester and breast cancer, applied in the application field of sterol phenolic acid ester in the preparation of drugs for preventing and treating breast cancer

Active Publication Date: 2015-09-30
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the anti-breast cancer effect of sterol phenolic esters

Method used

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  • Application of sterol phenolic acid esters in the preparation of breast cancer drugs
  • Application of sterol phenolic acid esters in the preparation of breast cancer drugs
  • Application of sterol phenolic acid esters in the preparation of breast cancer drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation method of sterol phenolic acid ester in embodiment 1, rice bran

[0025] Take 1000g of rice bran and extract it three times with acetone (each time: the amount of acetone used is 10L, the extraction temperature is 50°C, and the extraction time is 4 hours), and the extracts obtained by combining the three times are spin-dried with a rotary evaporator (at 45°C), Take the spin-dried product and dissolve it in methanol solution of KOH (1000ml, the concentration of KOH is 2mol / L), and extract it with n-hexane at room temperature for 3 times (each time: the amount of n-hexane is 1000ml, and the extraction time is 10 minutes) , collect the methanol phase (located in the lower layer) obtained 3 times, add hydrochloric acid (concentration: 2mol / L, dosage: 1000ml) to acidify, then use n-hexane to extract 3 times at room temperature (each time: the dosage of n-hexane is 1000ml, and the extraction time is 10 Minutes), the obtained n-hexane phase (located in the uppe...

Embodiment 2

[0027] The preparation method of sterol phenolic acid ester in embodiment 2, corn bran

[0028] With reference to the method described in Example 1:

[0029] Take 2000g of corn bran, extract it three times with acetone, spin the extract to dryness with a rotary evaporator, dissolve the spin-dried residue in methanol solution of KOH, and extract three times with n-hexane, collect the methanol phase, add hydrochloric acid to acidify it, and use n-hexane The n-hexane phase was extracted three times, and the n-hexane phase was collected, blown to dry with nitrogen to obtain sterol phenolate, and the total amount was 64.1 g.

[0030] According to the quantitative analysis by HPLC, the sterol phenolic esters in corn hulls contain 24-methylenecycloartenol ferulate, cycloartenol ferulate, β-sitosterol ferulate , dihydrositosterol ferulate and campesterol ferulate, the contents of which are 5%, 4.5%, 20%, 10% and 15% respectively, which account for 54.5% of the total.

Embodiment 3

[0031] The preparation method of sterol phenoxylate in embodiment 3, bran

[0032] With reference to the method described in Example 1:

[0033] Take 3000g of bran, extract three times with acetone, spin dry the extract with a rotary evaporator, dissolve the spin-dried residue in methanol solution of KOH, and extract three times with n-hexane, collect the methanol phase, acidify with hydrochloric acid, and use n-hexane The n-hexane phase was extracted three times, and the n-hexane phase was collected, blown to dry with nitrogen to obtain sterol phenolic acid ester, and the total amount was 43.5 g.

[0034]According to the quantitative analysis by HPLC, the sterol phenolic esters in the bran contain stigmasteryl ferulate, cycloartenol ferulate, β-sitosteryl ferulate (β-Sitosteryl ferulate) and rapeseed oil The content of sterol ferulic acid ester is 10%, 2%, 1%, 25% respectively, which accounts for 38% of the total.

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Abstract

The invention relates to the application of sterol phenolic ester to preparation of health care foods or medicines for resisting breast cancer, in particular to the application of sterol phenolic ester to preparation of breast cancer prevention and treatment medicine. The sterol phenolic ester is at least one of 24-methylenecycloartenyl ferulate, cycloartenyl ferulate, beta-sitosteryl ferulate, stigmasteryl ferulate, campesteryl ferulate, campesteryl alkanol ferulate, campesteryl ferulate, 24-methylcholestanyl ferulate, 24- methenylcholestanyl ferulate and dihydro-sitosteryl ferulate.

Description

technical field [0001] The invention relates to the application of sterol phenolic acid ester in the preparation of anti-breast cancer health food or medicine. Background technique [0002] Breast cancer is one of the most common malignant tumors in women, ranking first in female malignant tumors. Around the world, about 1.35 million women are diagnosed with breast cancer each year, and about 500,000 women die from the tumor. Its incidence rate accounts for 7% to 10% of malignant tumors in my country. In recent years, the incidence of breast cancer has been increasing year by year, and the age of onset is also significantly younger, which seriously threatens the health of women. Breast cancer treatments include surgery, radiotherapy, chemotherapy, endocrine therapy, and molecular targeted therapy. Chemotherapy drugs for breast cancer include cyclophosphamide, methotrexate, and fluorouracil in the 1970s, anthracyclines doxorubicin and epirubicin in the 1980s, and taxanes s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61P35/00A23L1/29A23L33/00
Inventor 陆柏益杨佳佳胡银洲熊丽娜周菲毛淑琴蒋易蓉谌灿曦
Owner ZHEJIANG UNIV
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