Terahertz time-domain spectroscopy method for quantitatively detecting tetracycline hydrochloride solutions

A tetracycline hydrochloride, terahertz time-domain technology, applied in the direction of measuring devices, material analysis through optical means, instruments, etc., can solve the problems of complex experimental data processing and measurement result errors, and achieve accurate and relatively accurate test results. Pre-processing simple effects

Active Publication Date: 2014-01-01
ZHEJIANG UNIV
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  • Abstract
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Problems solved by technology

[0004] At present, the terahertz technology detection method for liquid samples is mainly the liquid pool method. However, the cuvette or other material sample pools will have multiple reflections and FP effects, w

Method used

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  • Terahertz time-domain spectroscopy method for quantitatively detecting tetracycline hydrochloride solutions
  • Terahertz time-domain spectroscopy method for quantitatively detecting tetracycline hydrochloride solutions
  • Terahertz time-domain spectroscopy method for quantitatively detecting tetracycline hydrochloride solutions

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Embodiment

[0052] The polyvinylidene fluoride film is provided by Millipore, USA.

[0053] The tetracycline hydrochloride is tetracycline hydrochloride from Aladdin Reagent Company (product number: T105493)

[0054] The water used as the solvent is deionized water (18.2 MΩ·cm, Millipore, USA).

[0055] The concentration (g / 100ml) of the tetracycline hydrochloride aqueous solution is 0%, 0.01%, 0.05%, 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1.0%, 1.2%, 1.4%, 1.6%, 1.8% %,2%.

[0056] The terahertz time-domain spectroscopy system is a model Z-3 terahertz time-domain spectroscopy system produced by Z-Omega Company.

[0057] Soak the dry polyvinylidene fluoride film with a thickness of 0.1mm in the tetracycline hydrochloride aqueous solution, prepare three samples for each concentration, let it stand for 10 minutes, and let it dry naturally for 12 hours; turn on the laser until the output power is stable, and check the light in the optical path Whether it is collimated or not; turn on the laptop, s...

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Abstract

The invention discloses a terahertz time-domain spectroscopy method for quantitatively detecting tetracycline hydrochloride solutions. The method comprises the following steps: preparing polyvinylidene fluoride film samples of the tetracycline hydrochloride solutions with different concentrations; collecting terahertz time-domain spectroscopies of the polyvinylidene fluoride film samples of the tetracycline hydrochloride solutions; performing fourier transform processing on the terahertz time-domain spectroscopies of the polyvinylidene fluoride film samples, and using a formula to obtain absorption spectrums of the polyvinylidene fluoride film samples; establishing a correction model for predicting tetracycline hydrochloride concentrations; performing verification and evaluation on the correction model. The method can realize quantitative detection of the tetracycline hydrochloride solutions, and has the advantages of simplicity in pretreatment of the samples, easiness in operation, good repeatability, simplicity in data processing, relative accuracy in testing results and the like. Therefore, an important significance is provided by using the terahertz time-domain spectroscopy technology to detect antibiotic residues in liquid food.

Description

technical field [0001] The invention relates to a method for quantitatively detecting tetracycline hydrochloride aqueous solution, in particular to a method for detecting tetracycline hydrochloride aqueous solution by using terahertz time-domain spectroscopy. Background technique [0002] Tetracyclines are widely used in the prevention and treatment of animal diseases due to their excellent antibacterial properties, stability and low price. However, the abuse of tetracyclines leads to the enhancement of bacterial resistance and directly endangers the health of consumers. Therefore, in order to protect public health and safety, the detection of tetracyclines is very important. At present, the commonly used detection methods for tetracycline antibiotics mainly include microbiological methods, chromatography methods, and immunological methods. The pharmacopoeia generally adopts the microbial method, which can reflect the biological potency, but the operation is cumbersome and...

Claims

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Application Information

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IPC IPC(8): G01N21/3586
Inventor 应义斌秦坚源谢丽娟
Owner ZHEJIANG UNIV
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