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Application of myricetin in preparing preparation for inhibiting hepcidin expression

A technology of hepcidin and preparations, which is applied in the application field of myricetin in the preparation of preparations for inhibiting the expression of hepcidin, and can solve problems such as difficulty in treatment

Inactive Publication Date: 2014-03-26
ZHEJIANG UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The low level of Hepcidin caused by genetic defects is an important factor in the occurrence and development of primary hemochromatosis; while the high expression of Hepcidin in refractory iron deficiency anemia (IRIDA) and chronic inflammatory anemia (ACI) brings great benefits for the treatment of diseases. certain degree of difficulty

Method used

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  • Application of myricetin in preparing preparation for inhibiting hepcidin expression
  • Application of myricetin in preparing preparation for inhibiting hepcidin expression
  • Application of myricetin in preparing preparation for inhibiting hepcidin expression

Examples

Experimental program
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Effect test

Embodiment 1

[0062] 1. Materials and Methods

[0063] 1.1 Preparation of experimental raw materials

[0064] Several representative active ingredients in black soybean hulls: Cyanin chloride, Kuromanin chloride, (+)-Catechin hydrate, β-Sitosterol, and Myricetin were all purchased from SIGMA. All active monomers were dissolved in sterile DMSO to the desired concentration. Lipopolysaccharide LPS was purchased from Santa Cruz Biotech.

[0065] 1.2 Cell lines

[0066] Human liver cancer cell line HepG2 and human kidney cell line HEK293 were provided by the Cell Bank of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. Culture conditions: DMEM high-glucose medium (GIBCO) containing 10% FBS (GIBCO), 37°C, 5% CO2 saturated humidity incubator.

[0067] 1.3 Luciferase luciferase reporter gene detection

[0068] according to Description of HD Transfection Reagent-Promega transfection system, inoculate HEK293 on 24-well plate 1 day before transfection, 5×10 4 / well, on...

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Abstract

The invention provides an application of myricetin in preparing a preparation for inhibiting hepcidin expression. Specifically, myricetin can be used for preparing a food supplement or a medicament for preventing and treating anemia of chronic inflammation (ACI), iron-refractory iron deficiency anemia (IRIDA) or renal anemia. The invention has the beneficial effects that the application of myricetin in preparing the preparation for inhibiting hepcidin expression provided by the invention provides a theoretical basis for myricetin to alleviate hepcidin increasing disease and especially provides a foundation for research and development of medicaments for anemia of chronic inflammation and iron-deficiency anemia.

Description

(1) Technical field [0001] The invention relates to the application of myricetin in the preparation of a preparation for inhibiting the expression of hepcidin. (2) Background technology [0002] Iron is one of the essential trace elements for the human body, and the imbalance of iron metabolism will lead to iron deficiency or iron overload in the body. Hepcidin secreted by the liver maintains the balance of iron homeostasis by controlling iron absorption and recycling. The low level of Hepcidin caused by genetic defects is an important factor in the occurrence and development of primary hemochromatosis; while the high expression of Hepcidin in refractory iron deficiency anemia (IRIDA) and chronic inflammatory anemia (ACI) brings great benefits for the treatment of diseases. Certain difficulty. [0003] Therefore, targeting Hepcidin and screening Hepcidin agonists or antagonists is of great significance for the treatment of iron metabolism disorders. (3) Contents of the i...

Claims

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Application Information

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IPC IPC(8): A61K31/352A23L1/29A61P7/06A23L33/00
Inventor 王福俤穆明道伍爱民杜晓利安鹏吴谦邵丹丹沈筱筠
Owner ZHEJIANG UNIV
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