Rhizoma dryopteris crassirhizomae aqueous extract and preparation method and application thereof

A technology of extracting water extracts of Mianma Guanzhong, applied in the field of water extracts of Mianma Guanzhong and its preparation, can solve the problems of anti-senile dementia and achieve the effect of improving learning and memory behavior

Active Publication Date: 2014-04-16
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] There is no report on the petroleum ether extraction of Mianma Guanzhong and its anti-senile dementia.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: the water extract of Mianmaguanzhong

[0056] 1) Take the rhizome and petiole residues of Mianmaguanzhong, crush them, pass through a 35-mesh sieve, and the particle size is 500 μm;

[0057] 2) Take 500 grams of Mianmaguanzhong coarse powder, soak in 2000mL of petroleum ether (60-90°C) for 24 hours, then extract by percolation until the color of the extract is light (equivalent to 5 times the amount of medicinal materials), and recover the residue;

[0058] 3) Evaporate to dry the petroleum ether in the residue provided in step 2), extract twice with 80% ethanol in an amount 3 times the volume of the residue, for 2 hours each time, and collect the residue and extract respectively;

[0059] 4) Decoct the residue obtained in step 3) with distilled water 6 times the weight of Mianmaguanzhong, decoct 2 times, 2 hours each time, combine the decoction twice, concentrate until dry, and obtain Mianmaguanzhong water Extract 56.52g (11.30% yield).

Embodiment 2

[0060] Embodiment 2: the water extract of Mianmaguanzhong

[0061] 1) Take the rhizome and petiole residues of Mianma Guanzhong, grind them, pass through a 60-mesh sieve, and the particle size is 250 μm;

[0062] 2) Take 500 grams of Mianmaguanzhong coarse powder, soak it in 2000mL of petroleum ether (60-90°C) for 24 hours, then extract by percolation until the color of the extract is light (equivalent to 6 times the amount of medicinal materials), and recover the residue;

[0063] 3) Evaporate to dry the petroleum ether in the residue provided in step 2), extract twice with 70% ethanol in an amount 5 times the volume of the residue, for 2 hours each time, and collect the residue and extract respectively;

[0064] 4) Decoct the residue obtained in step 3) with distilled water 8 times the weight of Mianma Guanzhong, decoct 3 times for 2 hours, 1.5 hours and 1.5 hours respectively, combine the water decoction three times, concentrate to dryness, 49.46 g (yield: 9.89%) of Mianma...

Embodiment 3

[0065] Embodiment 3: the water extract of Mianmaguanzhong

[0066] 1) Take the rhizome and petiole residues of Mianmaguanzhong, crush them, pass through 25 mesh, and the particle size is 710 μm;

[0067] 2) Take 500 grams of Mianma Guanzhong coarse powder, soak it in 2000mL of petroleum ether (60-90°C) for 36 hours, then extract by percolation until the color of the extract is light (equivalent to 6 times the amount of medicinal materials), and recover the residue;

[0068] 3) Evaporate the petroleum ether in the residue provided in step 2), extract 3 times with 90% ethanol with 6 times the volume of the residue, the extraction time is 2 hours, 1.5 hours, and 1.5 hours respectively, and collect the residue and extract respectively;

[0069] 4) Decoct the residue obtained in step 3) with distilled water 6 times the weight of Mianma Guanzhong, decoct 2 times, decocting time is 2h, 1.5h respectively, combine the decoction twice, concentrate to dryness, 63.59g (yield: 12.72%) of ...

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Abstract

The invention discloses a rhizoma dryopteris crassirhizomae aqueous extract and a preparation method and application thereof. The aqueous extract is prepared by comprising the following steps: decocting by water and concentrating a decoction to obtain the aqueous extract or the aqueous extract is prepared by adopting the following steps: smashing rhizoma dryopteris crassirhizomae, immersing the rhizoma dryopteris crassirhizomae by petroleum ether, performing percolation extraction, recycling residual slag, and extracting the residual slag by ethyl alcohol to obtain the residual slag and an extracting solution, decocting the residual slag by water, and concentrating a decoction to obtain the rhizoma dryopteris crassirhizomae aqueous extract. The rhizoma dryopteris crassirhizomae aqueous extract provided by the invention has the effects of preventing and treating senile dementia.

Description

technical field [0001] The present invention relates to the extract of Rhizoma miltiorrhiza, in particular to a water extract of Rhizoma mercifolia and its preparation method and application. Background technique [0002] Alzheimer's disease is a neurodegenerative disease that seriously threatens human health. Alzheimer's disease (abbreviated as AD) is a major senile dementia, manifested as memory, comprehension, calculation, judgment, orientation, language, abstract thinking, self-control and other ability impairments, resulting in the loss of independent living and working ability of patients. With the acceleration of social aging, AD has become the fourth leading cause of human death. my country is about to enter an aging society, and the disease is gradually showing a younger trend, and the incidence rate is increasing year by year. So far there is no effective means to cure Alzheimer's disease, but taking acetylcholinesterase inhibitors (ACHEI) is currently the most ef...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61P25/28
Inventor 陈士林黄林芳王冬梅刘艾林杨大坚徐宏喜卞兆祥陈新滋
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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