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A kind of purposes of coniferyl ferulate

A technology of coniferyl ferulate and application, which is applied in the new application field of known compounds and can solve problems such as large toxic and side effects

Active Publication Date: 2016-01-20
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the anti-hepatic fibrosis drugs are in the experimental research stage, and few of them are actually used in clinical practice, and they have relatively large toxic and side effects

Method used

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  • A kind of purposes of coniferyl ferulate
  • A kind of purposes of coniferyl ferulate
  • A kind of purposes of coniferyl ferulate

Examples

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Comparison scheme
Effect test

experiment example 1

[0016] 1. Purpose of the experiment: To investigate the anti-fibrosis effect of coniferyl ferulate

[0017] 2. Experimental method:

[0018] Experimental animals: the experimental animals used in the present invention are C57BL / 6 mice, weighing 20-22 g, male, provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine.

[0019] Carbon tetrachloride (CCl4) and olive oil used in the experiment were purchased from Sinopharm Chemical Reagent Co., Ltd.; coniferyl ferulate (content 98.94%) was purchased from Chengdu Zhibiao Pure Biotechnology Co., Ltd.

[0020] Thirty C57BL mice, SPF grade, were divided into normal group (Control, n=10), CCl4 model group (CCl4, n=10), coniferyl ferulate group (coniferyferulate, n=10). Modeling method, the model group and the coniferyl ferulate group were intraperitoneally injected with 10% CCl4 olive oil 2ml / kg, 3 times a week, and the model was established for 5 weeks. From the 3rd week onwards, while continu...

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Abstract

The invention relates to novel application of known compound coniferyl ferulate, and belongs to the technical field of medicines. Completed animal model tests indicate that the abnormal liver function of a CC14 induced mouse liver fibrosis model can be remarkably improved after coniferyl ferulate intervenes, the serum aspartate amino transferase and the level of serum total bilirubin can be reduced, the content of hydroxyproline can be reduced, the activation of hepatic stellate cells can be inhibited, type I collagen expression can be reduced, and collagen deposition of hepatic tissues can be inhibited.

Description

technical field [0001] The invention relates to a new application of a known compound and belongs to the technical field of medicine. Background technique [0002] Existing studies have shown that Coniferylferulate exists in Angelica, Chuanxiong and other Umbelliferae plants, and has antibacterial, anticancer and antioxidative effects. Liver fibrosis is a common pathological stage of various chronic liver diseases, including viral hepatitis, fatty liver disease, autoimmune liver disease, etc. HBV infection is highly prevalent in my country, with approximately 6.9 million infected persons. The incidence of alcoholic and non-alcoholic steatohepatitis is also increasing year by year. Most patients with chronic hepatitis are accompanied by liver fibrosis, and 12%-25% of them will progress to liver cirrhosis within 5 years. At present, most of the anti-hepatic fibrosis drugs are in the stage of experimental research, few of which are actually used in clinical practice, and hav...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/216A61P1/16
Inventor 刘平周亚宁慕永平付文卫张华孙明瑜范魏伟李雪微陈佳美
Owner SHANGHAI UNIV OF T C M
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