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Carboxymethylated Derivatives of Exopolysaccharides of Trichodia granulosa and Their Application in the Preparation of Anti-renal Failure Drugs

A technology of extracellular polysaccharides and Trichomonas granulosa, applied in the direction of drug combination, urinary system diseases, etc., to achieve the effect of simple method, reducing MDA content, and overcoming gastric discomfort

Inactive Publication Date: 2015-12-09
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But at present, there is no public literature at home and abroad that mentions the carboxymethylated derivatives of the exopolysaccharide of Trichomonas granulosa and its application in the preparation of anti-chronic renal failure drugs.

Method used

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  • Carboxymethylated Derivatives of Exopolysaccharides of Trichodia granulosa and Their Application in the Preparation of Anti-renal Failure Drugs
  • Carboxymethylated Derivatives of Exopolysaccharides of Trichodia granulosa and Their Application in the Preparation of Anti-renal Failure Drugs
  • Carboxymethylated Derivatives of Exopolysaccharides of Trichodia granulosa and Their Application in the Preparation of Anti-renal Failure Drugs

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Embodiment 1

[0016] 1. Preparation of exopolysaccharide from Trichomonas granulosa YM281:

[0017] Using the method disclosed in Chinese Patent Application No. 201110184104.9, the strain preservation number is CCTCCNo: M2011196 (YM281) inoculated into a 5L fermenter with Trichodia granulosus, and the medium formula is: glucose 45g / L, yeast extract 14g / L , Glycine 6.0mg / L, MgSO 4 ·7H 2 O1g / L, KH 2 PO 4 1g / L, the loading factor volume ratio is 0.7, the inoculum size is 15% (volume ratio), the cultivation temperature is 35°C, the ventilation rate is 1.0L / min, the stirring speed is 180r / min, and the fermentation time is 12 days; After the fermentation broth was suction filtered and concentrated, 3 times its volume of ethanol with a volume ratio concentration of 95% was added, and alcohol precipitation was carried out at 4°C for 24 hours. The ethanol solution was centrifuged at 5000 r / min for 10 minutes, and the supernatant was removed. The resulting precipitate was dissolved in distilled wa...

Embodiment 2

[0076] First prepare and obtain the exopolysaccharide of Trichomyces granulosa according to the following conditions and methods: inoculate the Trichomyces granulosus with the strain preservation number CCTCCNo: M2011196 in a 4L fermenter, the medium formula is: glucose 40g / L, yeast extract 12g / L L, glycine 5.0mg / L, MgSO 4 ·7H 2 O1.1g / L, KH 2 PO 4 1.2g / L, the volume ratio of the loading factor is 0.6, the inoculum size is 12% (volume ratio), the culture temperature is 30°C, the ventilation rate is 1.1L / min, the stirring speed is 170r / min, and the fermentation time is 10 days; After suction filtering and concentrating the fermentation broth, add 2 times its volume of ethanol with a mass fraction of 95% and alcohol precipitation at 4°C for 24 hours, centrifuge the ethanol solution at 3500r / min for 10min, remove the supernatant, and precipitate with absolute ethanol, Wash 2-3 times with acetone, then dissolve with distilled water, deproteinize by Sevage method and add 1 / 3 volu...

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Abstract

The invention discloses a lachnum exopolysaccharides carboxymethylation derivative and an application thereof in preparation of chronic renal failure-resistant medicines. The lachnum exopolysaccharides carboxymethylation derivative is characterized in that lachnum exopolysaccharides with the strain collection number of CCTCC No: M 2011196 are subjected to chloroacetic acid carboxymethylation modification to obtain the lachnum exopolysaccharides carboxymethylation derivative, and the lachnum exopolysaccharides carboxymethylation derivative in an effective dose and medical auxiliary materials are prepared into tablets and capsules for clinical use according to a conventional preparation method in pharmaceutics due to the effect of obviously resisting chronic renal failure. The pharmacodynamic experiment proves that the exopolysaccharides and carboxymethylation derivative has an obvious effect of resisting chronic renal failure and does not have a toxic or side effect, and the preparation method is simple and economic.

Description

technical field [0001] The present invention belongs to the application of the exopolysaccharide of Trichodia granulosa in the field of medicine, and specifically relates to the carboxymethylated derivative of Trichodia granulosa exopolysaccharide and its preparation of anti-renal failure medicine. the use of. Background technique [0002] Modern medicine believes that the kidney is an important excretory organ of the human body. Its main function is to filter and form urine and discharge metabolic waste, and to regulate the electrolyte and acid-base balance in the body. Chronic renal failure is a progressive damage to the kidneys caused by various primary kidney diseases or secondary to other diseases. Syndrome has become a global public health problem. Hemodialysis and kidney transplantation can treat chronic renal failure and end-stage renal disease, but they are expensive and difficult to popularize. Clinically used drugs are usually Haikun Shenxi Capsules, Niaoduqing ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61K31/715A61P13/12
Inventor 叶明吴艳娜荆莲艳
Owner HEFEI UNIV OF TECH
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