106 results about "Trichophyton infection" patented technology

The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such a mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.

A biochip for detecting the pathogenic funguses features that the DNA probes respectively for detecting one of 20 pathogenic funguses including Candida albicans, Aspergillus fumigatus, etc are immobilized on the glass plate, silicon chip, or high-molecular material.

The invention encompasses hexapeptides consisting of alternating hydrophobic residues (B) at positions 2, 4, and 6, hydrophilic, charged residues (X) at positions 1 and 3, and a naphthylalanine (Nal), an aliphatic or aromatic residue (O) at position five, represented generally by the formula XBXBOB, which exhibit antimicrobial activity against infections caused by a variety of pathogens. These pathogens may include gram positive or negative bacteria, acid-fast bacteria such as mycobacteria, parasites, dermatophytes, or fungal pathogens. Typical fungal pathogens include Candida albicans and typical dermatophytes include Trichophyton rubrum and Trichophyton mentagrophytes. The hexapeptides of the present invention exhibit antifungal activity, antibacterial activity, desirable stability, and lack toxicity to the mammal receiving treatment.

Method and apparatus for using computer controlled, fiber-coupled laser delivery of treatment specific wavelength, intensity and duration of UV irradiation to control bacterial, fungal, viral and mold infections in bodily cavities, fluids and external applications. The method of treatment is focused on DNA breakdown beyond repair by natural DNA repair mechanisms of the pathogen, with less than damaging doses to tissues being treated, thus avoiding mutagenicity and carcinogenicity. The minimal intensity and duration and exposure area of any given surface of tissue to be treated is to be pre-determined by tissue and pathogen testing to optimize the therapeutic ratio. External applications include specifically Trichophyton Rubrum (toenail fungus) through the nail and Pseudomonas Aeruginosa infections in burns and elsewhere.

Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before a final diagnosis is obtained. The present invention is a rapid DNA extraction method extracting nucleic acids from fungi (e.g. dermatophytes and other pathogenic fungi) which can be performed from directly on hair, nail or skin specimens from humans, from naturally or experimentally infected animals or from cultured fungal colonies for the use in PCR amplification and detection assays. The present invention also includes specific primer sets for detection of any dermatophyte and for species specific detection of Trichophyton rubrum and Epidermophyton floccosum by PCR and a kit for diagnosing fungal infections.

Method and apparatus for using computer controlled, fiber-coupled laser delivery of treatment specific wavelength, intensity and duration of UV irradiation to control bacterial, fungal, viral and mold infections in bodily cavities, fluids and external applications. The method of treatment is focused on DNA breakdown beyond repair by natural DNA repair mechanisms of the pathogen, with less than damaging doses to tissues being treated, thus avoiding mutagenicity and carcinogenicity. The minimal intensity and duration and exposure area of any given surface of tissue to be treated is to be pre-determined by tissue and pathogen testing to optimize the therapeutic ratio. External applications include specifically Trichophyton Rubrum (toenail fungus) through the nail and Pseudomonas Aeruginosa infections in burns and elsewhere.

Provided is anti-bacterial fabric for shoes and a production process thereof. Warp-knitted spacer fabric is adopted and comprises a surface layer for decoration, an inner layer in contact with the skin, and a spacing layer arranged between the surface layer and the inner layer. The inner layer is formed in such a manner that far infrared polyester fibers and chinlon-based cupric ion anti-bacterial fibers are interwoven. The far infrared polyester fibers serve as the spacing layer. In a bacteriostatic test of fabric, the bacteriostasis rate of Candida albicans reaches at 95.76%, the bacteriostasis rate of trichophyton rubrum reaches at 96.96%, the bacteriostasis rate of staphylococcus aureus reaches at 99.23%, and the bacteriostasis rate of colibacillus reaches at 99.99%. The anti-bacterial fabric has composite functions of heat preservation, bacteria prevention, health care, moisture conductivity and perspiration.

The present invention relates to a method of treating a fungal condition caused by T. rubrum, by administering a composition comprising a fatty acid monoester of glycerol. According to an embodiment, the fatty acid monoester of glycerol is 1-monocaprin. According to another embodiment, the fungal condition is onychomycosis.

The present invention discloses a lysostaphin compounded preparation. Said preparation comprises bacteria-killing effective quantity of lysostaphin and lysozyme. Said lysostaphin compounded preparation has higher bacteria-killing effect as compared with single lysostaphin, not only has the strong bacteria-killing action for Gram-positive bacterium and Gram-negative bacterium, but also has the good effect for killing the fungi of Candida albicans and red trichophyton, etc. It has high bacteria-killing activity and stability, does not produce drug resistance, and has no toxic side effect.

The present invention relates to a formulation and method for the treatment of fungal nail infections, such as those caused by Trichophyton rubrum and / or Aspergillus niger. The formulation of the invention comprises glucose oxidase, D-glucose and hydrogen peroxide in an aqueous solution. Advantageously, the formulation of the invention provides a two-stage hydrogen peroxide release for the treatment of the fungal nail infections.

The invention relates to a novel wide-spectrum bacterial strain Bacillus sp. AH-E-1 inhibiting clinical and plant pathogenic fungi, and an application thereof. The main content comprises: (1) Bacillus sp. AH-E-1 is a newly-discovered bacillus strain or subspecies; (2) Bacillus sp. AH-E-1 can produce anti-fungus substances after fermentation under appropriate conditions; (3) Bacillus sp. AH-E-1 can significantly inhibit 20 clinical pathogenic fungi such as aspergillus flavus, aspergillus fumigates, trichophyton rubrum, trichophyton mentagrophyte, candida glabrata, cryptococcus neoformans, and the like; (4) Bacillus sp. AH-E-1 can significantly inhibit 13 plant pathogenic fungi such as staphylococcus, magnaporthe oryzae, rhizopusstolonife, and the like. The invention provides an excellent novel anti-fungus substance producing bacterial strain which has the advantages of wide fungus-inhibiting spectrum, obvious effect, and the like.

The invention provides a method for identifying five dermatophytes by utilizing a high-resolution melting curve and belongs to the technical field of high-resolution melting curve analysis. The methodadopts a pair of specific primers and is based on real-time fluorescence PCR melting curve to identify trichophyton rubrum, trichophyton digitorum, epidermophyton floccosum, microsporum caninum and Microsporum incurvatum. The sequence of the pair of specific primers is as shown as SEQ ID NO.1-2. The method has the advantages of high sensitivity, good specificity and high detection speed, can be used for identifying dermatophytes on the aspects of clinical diagnosis, environmental monitoring, food safety and the like, and provides a reliable basis for infection treatment, environmental sanitation and food safety monitoring of dermatophytes.

A ring-shaped toe-patch is provided for treatment and prevention of tinea pedis, commonly known as athlete's foot. The toe-patches are made of rubber-foam, attached to a hydrophobic material for elimination of fungus like T. rubrum. The toe-patch has cuts extending into the patch from the central circle in the toe-patch. Due to its perfect fit the toe-patch comes close to the affected area making it possible for a hydrophobic material attached to foam to effectively bind the fungi. Simultaneously with the elimination of the fungi the toe-patch works as a toe separator creating space between the toes.

The invention discloses an antifungal compound extract, a preparation and a preparation method of the extract. The antifungal compound extract comprises the following components in parts by weight: 1-3 parts of a gallnut extract, 1-3 parts of a fructus cnidii extract, 1-3 parts of a pogostemon cablin extract, 0.5-1.5 parts of a galangal extract, 0.5-1.5 parts of a radix sophorae flavescentis extract, 0.5-1.5 parts of a radix clematidis extract, 0.5-1.5 parts of a fructus kochiae extract and 0-80 parts of an ethanol-water solution. The components of the antifungal compound extract are extractedby adopting a hot reflux extraction method; and ethanol-separated and purified liquid obtained after separation and purification of macroporous adsorption resin has an obvious effect of resisting trichophyton rubrum and tritirachium album and can be used for preventing and treating fungal infection of human skin, hair and nails. Meanwhile, plant extracts are compounded to be prepared into powderygranules, the solubility is increased, the state is good, the medicine curative effect is long, and the medication form is convenient.

A biochip for detecting the pathogenic funguses features that the DNA probes respectively for detecting one of 20 pathogenic funguses including Candida albicans, Aspergillus fumigatus, etc are immobilized on the glass plate, silicon chip, or high-molecular material.

The invention relates to application of oxidized resveratrol and combined oxidized resveratrol and antibiotic in the preparation of an anti-fungal-infection product, belonging to the technical field of medicines. Oxidized resveratrol contains nautical components, is good in safety and has good antibacterial capacity to trichophyton rubrum and Candida albicans. When the oxidized resveratrol and an antibiotic, namely econazole nitrate jointly act on the two bacteria, the antibacterial effects on the two bacteria are superior to the antibacterial effects of dependent independent oxidized resveratrol and antibiotic on the two bacteria under the same use concentration, so that natural oxidized resveratrol is used for replacing partial econazole nitrate so as to inhibit fungi, the use amount of econazole nitrate can be reduced, and the research and development of novel, efficient and natural anti-fungal-infection drugs are benefited.

The invention provides a triazole compound shown as a general formula (I), optical isomers or the pharmaceutically acceptable salts thereof, and application of the compound, optical isomers or pharmaceutically acceptable salts thereof to preparation of medicaments for resisting fungi, especially Candida albicans, Candida parapsilosis, Candida glabrata, Cryptococcus neoformans, Microsporum flavescens, Trichophyton rubrum and / or Aspergillus fumigatus. The invention provides a pharmaceutical composition, comprising a therapeutically effective amount of one or more selected from the compound shown in the formula (I), optical isomers and pharmaceutically acceptable salts thereof and pharmaceutic adjuvants.

An embodiment of the invention discloses a trichophyton rubrum infection model preparation method and application. The preparation method includes the steps: separating a corium layer and a cuticularlayer of prepuce tissues, and digesting and culturing the cuticular layer to obtain human keratinocytes; finally, adding the human keratinocytes to a collagen scaffold and culturing the human keratinocytes to form a tissue engineering skin model. The model is simple to operate and easy to observe and solves the problem that a current trichophyton rubrum infection animal model is not easily observed. Seeds of the trichophyton rubrum infection model are the human keratinocytes and closer to the biological state of human skin fungal infection.

The invention discloses an antibacterial anti-inflammatory medical gel. The antibacterial anti-inflammatory medical gel is prepared from agarose, sodium alginate, nopol, rue oil, artemisia apiacea oil, diallyl disulfide, terpinene, sodium diacetate, histidine, sodium lactate, silymarin, cyanobacteria extract, magnesium chloride, vitamin P, tween-20, glycerin, and water. The invention also discloses a preparation method of the antibacterial anti-inflammatory medical gel. The antibacterial anti-inflammatory medical gel possesses excellent antibacterial anti-inflammatory effect; inhibition rate on staphylococcus aureus, pseudomonas aeruginosa, trichophyton rubrum, and candida albicans is 93.5% or higher; it is confirmed by rabbit skin test that no skin erythema, or edema, or irritation is caused by the antibacterial anti-inflammatory medical gel, and the antibacterial anti-inflammatory medical gel is safe and reliable to use.

The invention relates to a Chinese medicinal plaster for treating beriberi, which is prepared from wild or planted Rumex crispus L. through the steps of removing impurities, cleaning, slicing, disintegrating, drying, ethanol lixiviating, concentrating, freeze-drying, making grease form medicament, sterilizing and packaging.

The invention relates to an application of ellagic acid to preparation of drugs for treating and preventing fungal infection of a human body. According to the application, the in-vitro fungi inhibition activity of ellagic acid to 23 fungi is studied and the MIC (minimal inhibitory concentration) value is measured; an in-vitro activity result of ellagic acid to the fungi shows that the MIC value of ellagic acid to 6 dermatophytes is 6.25-50 microgram / ml, and ellagic acid has a better inhibition effect on clinical common superficial pathogenic fungi and is especially sensitive to trichophyton rubrum; the MIC value of ellagic acid to 6 clinical common candida is 25-200 microgram / ml; ellagic acid is orally taken and externally used to treat a cavy skin trichophyton rubrum infection model, and the effect of treating a mouse fungal infection model by injecting ellagic acid or ellagic acid and fluconazole is studied; a study result shows that ellagic acid has a certain treatment effect on the cavy skin trichophyton rubrum infection model after being orally taken and externally used.

The invention relates to the technical field of medicines, particularly to six triterpene glycosides antifungal compounds HolotoxinD-I separated from a sea cucumber. The chemical structural formula isas follows on the right. An in vitro anifungal experiment shows that the compounds have obvious inhibitory effect on Candida ablbicans SC5314, Cryptococcus neoformans BLS108, Candida tropicalis, Trichophyton rubrum, Mircrosporum gypeseum and fuming Aspergillus. The invention can provide leading compounds for developing novel antifungal drug, and has a significant value on exploiting and using marine medical resources in China.

The present invention relates to the technical field of medicines and discloses dryopteris fragrans phloroglucinol derivatives, a separation and preparation method for isomers thereof and an application thereof Phloroglucinol compounds are separated and prepared from dryopteris fragrans(L.)Schott, which belongs to dryopteridaceae dryopteris plants, for the first time, and 4 pairs of isomers are discovered, wherein the 4 pairs of isomeric compounds have relatively strong effect of resisting skin superficial fungi. According to the in-vitro bacteriostatic experiment, the compounds provided by the present invention have good bacteriostatic effect on two skin pathogenic fungi, namely trichophyton rubrum and microsporum gypseum, and have characteristics of being low in side effect and being not liable to become resistant to the drug, and the like, thereby providing a novel natural compound for the treatment of skin superficial fungi infection and providing powerful technical support for preparing anti skin superficial fungi infection drugs or pharmaceutical compositions.

The invention relates to a method for determining the activity of a trichophyton rubrum keratinase. The method comprises the following steps: (1), constructing an artificial skin containing epidermis and dermis structures: resuspending human skin fibroblast cells in a collagen liquid, dropwise adding into a cell culture well plate and culturing; after the cells are completely expanded, dropwise adding a human keratinocyte suspension to the surface of collagen gel and continuously culturing; carrying out air-liquid interface culture when the human keratinocytes completely cover the surface of the collagen gel; and stopping culturing until a cuticular layer is differentiated into 5-8 layers; (2) carrying out artificial infection on trichophyton rubrum; and (3) determining the activity of the keratinase. The artificial skin, which is constructed by the method disclosed by the invention, becomes a natural inducer for production of the keratinase and has the following advantages that firstly, the artificial skin contains the dermal layer, the epidermal layer and 5-8 cuticular layers and the structure and function are closer to those of the human skin; secondly, keratin secreted by the keratinocyte in the epidermal layer is used as a natural substrate to induce the production of the keratinase; and, thirdly, the keratinase produced by inducing the natural substrate keratin, is accurate, real and stable in the determination of the activity.

The invention relates to a usage of an ocean fungal extract-active natural product B. According to the result of an in vitro research trial, the active natural product B has certain inhibitory effecton common clinical pathogenic fungi such as white tritirachium album limber, cryptococcus neoformans, trichophyton rubrum and aspergillus fumigatus and the like, is able to inordinately inhibit the growth of tumor cell lines such as liver cancer, breast cancer and lung cancer and the like, and is able to have stronger protective effect on pathological mechanism damages caused by rat multi-infarctcerebral ischemia damage and the like, thus being capable of obviously improving the learning and memory functions of dementia rat, and being applied to prepare dementia product having anti-angiogeniceffect. The invention provides a new pharmaceutical source for the curing of clinical antifungal, antitumor and anti-vascular dementia and directly related diseases thereof, having important value for developing and utilizing the pharmaceutical resource of our country.

The invention relates to application of formononetin in trichophyton rubrum. The technical scheme of the invention is the application of formononetin in preparing medicaments for treating antifungal infected diseases, wherein the fungus is trichophyton rubrum. The compound has an excellent antifungal activity on various superficial and deep funguses, has the advantages of high activity, low toxicity, broad antifungal spectrum and the like when being compared with an antifungal medicament in existing clinical application, and can be used for preparing antifungal medicaments.

The invention relates to an application of Scopariusins in the preparation of antihuman fungal medicines, and belongs to the medicinal field. Scopariusins has a very strong Trichophyton rubrum, Microsporum lanosum or Trichophyton tonsurans inhibition effect, so the Scopariusins can be used as an antihuman fungal compound, and is expected to be applied in the preparation of related medicines. The skeleton type of the Scopariusins is a brand new skeleton type, and the Scopariusins has a strong human fungus inhibition activity, has prominent substantive characteristics, and is a substantial improvement in the prevention and treatment of human fungal infection.

The invention discloses a coconut fiber and chemical fiber blended yarn which is formed by blending coconut fibers with chemical fibers, the chemical fibers are one or more of copper ammonia fibers, acrylic fibers, chinlon, modal, tencel and viscose glue. The coconut fiber and chemical fiber blended yarn disclosed by the invention is smooth in material surface, good in air permeability, high in toughness and heatproof and can resist the damage caused by escherichia coli O157, staphylococcus aureus, trichophyton tonsurans, trichophyton schoenleinii, trichophyton rubrum, candida albicans and other pathogenic bacteria.

The invention discloses a new compound I with the antifungal activity. The new compound I is obtained by systematic in-depth study on the chemical components of selaginella pulvinata maxim and separation from the selaginella pulvinata maxim through analysis on wave spectrum and mass spectrum data. Shown by in-vitro antifungal activity, the new compound I provided by the invention has obvious inhibiting effect on candida albicans, aspergillus fumigates, trichophyton rubrum and alpha fungus and the like, is low in toxicity and can be developed into a new antifungal medicine.