Antibacterial anti-inflammatory medical gel, and preparation method thereof

An antibacterial, anti-inflammatory and gel technology, applied in the field of medical materials, to achieve the effect of safe use

Inactive Publication Date: 2017-09-15
苏州凌科特新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide an antibacterial and anti-inflammat...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] An antibacterial and anti-inflammatory medical gel prepared from the following components, each component in parts by weight: 2 parts agarose, 1 part sodium alginate, 1.5 parts nopol, 1.8 parts ruta oil, and Artemisia annua oil 2.4 parts, diallyl disulfide 3.5 parts, terpinene 0.9 parts, sodium diacetate 4 parts, histidine 1 part, sodium lactate 0.9 parts, silymarin 0.5 parts, cyanobacteria extract 3.2 parts, magnesium chloride 2.1 parts, vitamins 0.4 parts of P, 0.8 parts of Tween-20, 12 parts of glycerin, 32 parts of water.

[0023] Preferably, the cyanobacteria extract is prepared by dissolving cyanobacteria in 20 times parts by weight of distilled water to make a suspension, frozen at low temperature to form a block and then thawed, and after repeated freezing and thawing three times, the cyanobacteria residue is removed after thawing and concentrated to 50mg / mL The concentration of cyanobacteria is obtained.

[0024] The preparation method of the antibacterial and anti...

Embodiment 2

[0030] An antibacterial and anti-inflammatory medical gel prepared from the following components, each component in parts by weight: 9 parts by weight: 9 parts of agarose, 6 parts of sodium alginate, 5 parts of nopol, 3.3 parts of ruta oil, and Artemisia annua oil 6 parts, 7 parts diallyl disulfide, 4.2 parts terpinene, 8 parts sodium diacetate, 3.5 parts histidine, 3 parts sodium lactate, 2.8 parts silymarin, 6 parts cyanobacteria extract, 5.5 parts magnesium chloride, vitamins 1.6 parts of P, 2.3 parts of Tween-20, 25 parts of glycerin, 45 parts of water.

[0031] Preferably, the cyanobacteria extract is prepared by dissolving cyanobacteria in 10 times parts by weight of distilled water to prepare a suspension, frozen at low temperature to form a block and then thawed, and after repeated freezing and thawing three times, the cyanobacteria residue is removed after thawing and concentrated to 100 mg / mL The concentration of cyanobacteria is obtained.

[0032] The preparation method...

Embodiment 3

[0038] An antibacterial and anti-inflammatory medical gel prepared from the following components, each component in parts by weight: 2.5 parts of agarose, 1.4 parts of sodium alginate, 1.9 parts of nopal alcohol, 2.1 parts of ruta oil, and Artemisia annua oil 2.7 parts, diallyl disulfide 3.9 parts, terpinene 1.1 parts, sodium diacetate 4.5 parts, histidine 1.4 parts, sodium lactate 1.3 parts, silymarin 0.9 parts, cyanobacteria extract 3.5 parts, magnesium chloride 2.3 parts, vitamins 0.8 parts of P, 0.9 parts of Tween-20, 14 parts of glycerin, 35 parts of water.

[0039] Preferably, the cyanobacteria extract is prepared by dissolving the cyanobacteria in 15 parts by weight of distilled water to make a suspension, frozen at a low temperature to form a block and then thawed, and after repeated freezing and thawing three times, the cyanobacteria residue is removed after thawing and concentrated to 75mg / mL The concentration of cyanobacteria is obtained.

[0040] The preparation method...

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Abstract

The invention discloses an antibacterial anti-inflammatory medical gel. The antibacterial anti-inflammatory medical gel is prepared from agarose, sodium alginate, nopol, rue oil, artemisia apiacea oil, diallyl disulfide, terpinene, sodium diacetate, histidine, sodium lactate, silymarin, cyanobacteria extract, magnesium chloride, vitamin P, tween-20, glycerin, and water. The invention also discloses a preparation method of the antibacterial anti-inflammatory medical gel. The antibacterial anti-inflammatory medical gel possesses excellent antibacterial anti-inflammatory effect; inhibition rate on staphylococcus aureus, pseudomonas aeruginosa, trichophyton rubrum, and candida albicans is 93.5% or higher; it is confirmed by rabbit skin test that no skin erythema, or edema, or irritation is caused by the antibacterial anti-inflammatory medical gel, and the antibacterial anti-inflammatory medical gel is safe and reliable to use.

Description

Technical field [0001] The invention belongs to the technical field of medical materials, and specifically relates to an antibacterial and anti-inflammatory medical gel and a preparation method thereof. Background technique [0002] Gels refer to thick liquid or semi-solid dosage forms made of drugs and a suitable matrix for transdermal or transmucosal administration with gel properties. The gel has a cross-linked structure and part of the solid properties, has swelling, syneresis, permeability and viscosity, and can control the release of the drug or its adhesion to the skin to deliver the drug through the skin, which can reduce Drug toxicity and adverse reactions have the advantages of using, feeling comfortable, easy to clean, and not polluting clothing. [0003] Gelling agents can generally be divided into aqueous gels and organic gels. Hydrogels include ordinary hydrogels and new hydrogels. Common hydrogels include polymers such as carbomer and polyvinyl alcohol, and cellulos...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/06A61K47/36A61K47/26A61K47/12A61K47/10A61K47/06A61K47/20A61P29/00A61P31/04A61P31/10A61P17/00A61K31/19A61K31/357A61K31/4172A61K31/7048A61K33/06A61K35/748
CPCA61K9/0014A61K9/06A61K31/19A61K31/357A61K31/4172A61K31/7048A61K33/06A61K35/748A61K36/282A61K36/899A61K47/06A61K47/10A61K47/12A61K47/20A61K47/26A61K47/36A61K2300/00
Inventor 凌天阳
Owner 苏州凌科特新材料有限公司
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