Application of ellagic acid to preparation of drugs for treating and preventing fungal infection of human body

Abstract

The invention relates to an application of ellagic acid to preparation of drugs for treating and preventing fungal infection of a human body. According to the application, the in-vitro fungi inhibition activity of ellagic acid to 23 fungi is studied and the MIC (minimal inhibitory concentration) value is measured; an in-vitro activity result of ellagic acid to the fungi shows that the MIC value of ellagic acid to 6 dermatophytes is 6.25-50 microgram/ml, and ellagic acid has a better inhibition effect on clinical common superficial pathogenic fungi and is especially sensitive to trichophyton rubrum; the MIC value of ellagic acid to 6 clinical common candida is 25-200 microgram/ml; ellagic acid is orally taken and externally used to treat a cavy skin trichophyton rubrum infection model, and the effect of treating a mouse fungal infection model by injecting ellagic acid or ellagic acid and fluconazole is studied; a study result shows that ellagic acid has a certain treatment effect on the cavy skin trichophyton rubrum infection model after being orally taken and externally used.

Description

technical field [0001] The invention relates to the application of ellagic acid in the preparation of medicines for treating and preventing human fungal infection diseases. Background technique [0002] The molecular formula of ellagic acid is C14H6O8, English name: ellagic acid, chemical name: 2,3,7,8-tetrahydroxy benzopyrano-5,4,3-cde benzopyran-5,10-dione. Slightly soluble in water and alcohol, soluble in alkali and pyridine, insoluble in ether. [0003] Ellagic acid can be obtained by extracting plants such as Dijincao, Bandijin, blackberry, raspberry, strawberry, cranberry, pecan, pomegranate, wolfberry, etc., and can also be obtained by chemical synthesis. [0004] With the progress of society and the improvement of people's living standards, people pay more and more attention to health and quality of life. Fungal infection is a common and frequently-occurring disease, and it has gradually increased in recent years. However, with the widespread use of antifungal agent...

AI Technical Summary

Problems solved by technology

[0004] With the progress of society and the improvement of people's living standards, people pay more and more attention to health and quality of life. Fungal infection is a common and frequently-occurring disease, and it has gradually increased in recent years. However, with the widespread use of antifungal agents application, clinical drug-resistant strains are increasing, coupled with the increasing resistance of pathogenic fungi to existing drugs, making fungal infections easy to occur and difficult to control

The antifungal drugs currently used clinically have played a role in controlling pathogenic fungal infections to a certain extent, but there are still many deficiencies, such as amphotericin B has severe nephrotoxicity; The cytochrome P450 system of animals also has an inhibitory effect, which in turn produces toxic and side effects, and a small number of users may also have severe liver toxicity; ketoconazole, fluconazole, itraconazole, etc. have all caused liver necrosis or hepatotoxicity to death report

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