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Usage of active natural product B for preparing antifungal and antitumor product

A technology for anti-tumor products and natural products, which is applied in the application field of active natural product B for preparing anti-fungal and anti-tumor products, can solve problems such as not yet discovered, and achieve the effect of significant social benefits

Inactive Publication Date: 2010-02-10
杭州双马生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0106] After literature search, so far, no active natural product B (polydatin, piceid) and its composition have been found to be directly used in the prevention, diagnosis, detection, protection, treatment and research of antifungal, antitumor, vascular dementia and Reports on senile dementia and its direct related diseases

Method used

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  • Usage of active natural product B for preparing antifungal and antitumor product
  • Usage of active natural product B for preparing antifungal and antitumor product
  • Usage of active natural product B for preparing antifungal and antitumor product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0344] Embodiment 1, the preparation of active natural product B powder injection

[0345] Take 10g of active natural product B, add 30g of dextran, add 1500ml of water for injection, adjust the pH to 9.0, stir to dissolve; add water for injection to 2000ml, add 3.0g of activated carbon for needles, stir for 30 minutes; decarbonize and filter; Filter with a 0.22μm microporous membrane; subpackage, half-stopper; freeze-dry, then stopper and cover.

Embodiment 2

[0346] Embodiment 2, the preparation of active natural product B powder injection

[0347] Take 50g of active natural product B, add 60g of mannitol, add 5000ml of water for injection, adjust the pH to 8.0, stir to dissolve; add water for injection to 6000ml, add 1g of activated carbon for needles, and stir for 30 minutes; decarbonize and filter; use 0.22 Filter with μm microporous membrane; subpackage, half-stopper; freeze-dry, then stopper and cover.

Embodiment 3

[0348] Embodiment 3, the preparation of active natural product B powder injection

[0349] Take 1g of active natural product B, add 50g of glucose, add 900ml of water for injection, adjust the pH to 8.5, stir to dissolve; add water for injection to 1000ml, add 1.5g of activated carbon for needles, and stir for 30 minutes; decarbonize and filter; use 0.22 Filter with μm microporous membrane; subpackage, half-stopper; freeze-dry, then stopper and cover.

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Abstract

The invention relates to a usage of an ocean fungal extract-active natural product B. According to the result of an in vitro research trial, the active natural product B has certain inhibitory effecton common clinical pathogenic fungi such as white tritirachium album limber, cryptococcus neoformans, trichophyton rubrum and aspergillus fumigatus and the like, is able to inordinately inhibit the growth of tumor cell lines such as liver cancer, breast cancer and lung cancer and the like, and is able to have stronger protective effect on pathological mechanism damages caused by rat multi-infarctcerebral ischemia damage and the like, thus being capable of obviously improving the learning and memory functions of dementia rat, and being applied to prepare dementia product having anti-angiogeniceffect. The invention provides a new pharmaceutical source for the curing of clinical antifungal, antitumor and anti-vascular dementia and directly related diseases thereof, having important value for developing and utilizing the pharmaceutical resource of our country.

Description

technical field [0001] The present invention relates to the field of medicine and food technology, in particular to the use of a traditional Chinese medicine extract—an active natural product for the preparation of antifungal, antitumor and antivascular senile dementia products, and more specifically to a Marine fungal extract - active natural product B, namely 4,6-Dihydroxy-3-methylene-10-propenyl-2-oxa-spiro[4,5]dec-8-ene-1,7-dione, for The preparation of antifungal, antitumor and antivascular senile dementia products. Background technique [0002] (1) Research overview of marine fungi [0003] 1 Overview [0004] Marine microorganisms have great potential to produce new biologically active substances because they live in a special biological environment. For decades, nearly 600 secondary metabolites with novel structures have been isolated and identified from marine fungi, and many compounds have shown good antitumor, antibacterial and antiviral activities; some other ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P31/10A61P35/00A61P25/28A23L1/29A23L1/28C12Q1/18A61K36/06C12R1/725C12R1/68C12R1/645
Inventor 秦路平游飞冯建平徐丽莉
Owner 杭州双马生物科技股份有限公司
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