4results about How to "Lower creatinine" patented technology

The invention provides application of phloretin in preparation of a medicine for preventing or treating renal ischemia-reperfusion injury, and belongs to the technical field of medical application. According to the application, research finds that the phloretin can up-regulate the protein expression level of PAK3 and reduce the apoptosis level under the conditions of renal ischemia reperfusion or hypoxia reoxygenation. On the basis, the phloretin or the pharmaceutically acceptable salt, ester or solvate thereof not only can be used as an activator of PAK3, but also can effectively inhibit cell apoptosis induced by renal ischemia reperfusion or hypoxia reoxygenation, so that a relatively good prevention and treatment effect on renal ischemia reperfusion injury caused by cell apoptosis is achieved. The application not only provides a new application for phloretin, but also provides a new drug choice for activation of PAK3, inhibition of apoptosis and renal ischemia-reperfusion injury, and has important guiding significance for prevention and treatment of renal ischemia-reperfusion injury.

This invention belongs to the field of biomedical technology, specifically relating to the application of dexphosserine in the preparation of drugs for the prevention and / or treatment of kidney injury. The dexphosserine can alleviate glycerol-induced acute kidney injury in mouse models, significantly reduce serum creatinine and urea nitrogen levels in mice with acute kidney injury, and improve kidney pathological damage, thus having a therapeutic effect on acute kidney injury and broad application prospects.

The invention discloses application of black borneol in preparation of a Mongolian medicine for treating uremia moderate metabolic acidosis, and belongs to the technical field of biological medicine. The Mongolian medicine is applied by taking processed black borneol as an active ingredient. Clinical observation and verification prove that the Mongolian medicine has an excellent treatment effect in improvement of carbon dioxide binding force and reduction of creatinine. Therefore, a theoretical basis is provided for clinical application of the black borneol, and guidance is provided for further development of the black borneol. The quality and the curative effect of the black borneol are improved by optimizing the preparation process of the black borneol. By means of improving the processing method, improving the extraction efficiency and the like, a more stable and effective black borneol preparation can be prepared. The Mongolian medicine can be used for promoting application and development of the Mongolian medicine in uremia treatment. By developing the Mongolian medicine black borneol with unique curative effect and low side effect, more treatment choices and possibilities can be provided for uremia patients.

The invention discloses an enzymatic hydrolysis method, enzymatic hydrolysis product and application of a Sipuncula spp., and belongs to the field of biomedical technology. The Sipuncula spp. enzymatic hydrolysis product provided by the invention has good water solubility and no toxicity. The Sipuncula spp. enzymatic hydrolysis product can significantly reduce the content of creatinine and urea nitrogen in the blood, significantly downregulate serum insulin levels, reduce insulin resistance index (HOMA-IR), increase insulin sensitivity (HOMA-IS), and significantly reduce the expression of inflammatory factors IL-1β, TNF-α, IL-6, and CRP in renal tissue, and improve renal tissue pathological damage caused by diabetes.