The invention provides a method for preparing Shenshuaining preparations with a polymeric flocculation and precipitation technology. The method specifically comprises the following steps of: preparing the following bulk drugs: Radix Pseudostellariae, Coptis, prepared pinellia tuber, tangerine peel, Poria cocos, rhubarb, etc.; preparing rhubarb powder; preparing a rhubarb thick paste, adding a flocculating agent into a percolation solution; preparing a medicinal thick paste, and adding a flocculating agent into an extracting solution; preparing a mixed thick paste; mixing the mixed thick paste and the rhubarb powder uniformly; conducting drying and crushing so as to obtain Shenshuaining medicinal powder; preparing the Shenshuaining powder into capsules, tablets, granules, pulvis, and oral liquid preparations; conducting inspection on the preparations with high-performance liquid chromatography, taking a mobile phase composed of methanol and water (45:55), controlling the detection wavelength at 254nm and the theoretical plate number greater than or equal to 5000, with the total alkaloid content, in terms of berberine hydrochloride, greater than 3.2mg in per 0.35g of the preparations. The Shenshuaining preparations of the invention have enhanced chemical stability, stable product quality, better content homogeneity, very low content deviation, and greatly increased effective components. When the preparations are absorbed, the contents can be rapidly released, and the in vivo utilization rate and absorption rate are high.