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Dragon tree leaf/dendrobe pharmaceutical composition, and preparation method, preparation and application thereof

A composition and leaf technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of difficult storage and storage, low bioavailability, poor quality stability, etc., to achieve improved bioavailability, good solubility, The effect of improving the absorption effect

Active Publication Date: 2014-05-21
普洱淞茂滇草六味制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional Chinese herbal pieces are not only troublesome to cook and inconvenient to use, but also have poor quality stability and are not easy to store and keep. Due to low bioavailability, the amount of original medicine used is high. These defects have long been the main obstacles restricting the development of Chinese herbal pieces.

Method used

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  • Dragon tree leaf/dendrobe pharmaceutical composition, and preparation method, preparation and application thereof
  • Dragon tree leaf/dendrobe pharmaceutical composition, and preparation method, preparation and application thereof
  • Dragon tree leaf/dendrobe pharmaceutical composition, and preparation method, preparation and application thereof

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Effect test

preparation example Construction

[0027] The preparation method of the dragon's blood leaf and the Dendrobium medicinal composition of the present invention includes pretreatment, coarse pulverization, ultrafine pulverization and mixing processes, specifically including:

[0028] A, pretreatment: remove the sundries in the leaves of dracaena dracaena and Dendrobium dendrobii, clean, wash, air in the sun, and dry until the water content is ≤3% for later use;

[0029] B, coarse pulverization: leaves of dragon's blood and dendrobium are pulverized with coarse pulverizer respectively, cross 100~140 mesh sieves for subsequent use;

[0030] C, superfine pulverization: the coarse powder of dragon's blood leaf is pulverized into ultrafine powder of particle diameter 10~15 μm with jet mill, and the coarse powder of dendrobium is pulverized into superfine powder of particle diameter 6~12 μm with vibration mill;

[0031] D. Mixing: 45-55 parts by weight of Dracaena superfine powder and 45-55 parts of Dendrobium superfine...

Embodiment 1

[0054] - the preparation of the pharmaceutical composition

[0055] A, pretreatment: get sword leaf dracaena ( Dracaena cochinchinensis (Lour.) S. C. Chen) leaves 10kg, Dendrobium officinale ( Dendrobium candidum ) 10kg, remove the sundries, rinse with running water after net selection, then put it in the sun to dry, and dry it naturally until the moisture content does not change, then put the leaves of dracaena dracaena and Dendrobium candidum in RXH type hot air In a circulating dryer, dry to a moisture content of ≤3% for later use.

[0056] B. Coarse crushing: the leaves of Dracaena dracaena and Dendrobium candidum are pulverized with a Circoplex classifier grinder respectively, the coarse powder of leaves of Dracaena dracaena is passed through a 110-mesh sieve for subsequent use, and the coarse powder of Dendrobium candidum is passed through a 130-mesh sieve for subsequent use.

[0057] C. Superfine crushing: Grind the coarse powder of dracaena glabra leaves with a TC-2...

Embodiment 2

[0061] ——Pharmacological experiment on inhibition of mammary gland hyperplasia

[0062] Experimental Materials:

[0063] (1) Experimental drug: the pharmaceutical composition of the present invention prepared in Example 1, dracaena leaf powder, dendrobium powder, mixed by weight ratio 1:2, 1:3, 3:1, 2:1 Dracaena leaf powder: Dendrobium powder pharmaceutical composition, Rupi Sanjie capsule, estradiol benzoate injection, progesterone injection, heparin sodium, 10% formaldehyde solution, paraffin. Among them, Dracaena leaf powder is prepared and inspected in accordance with the quality standards stipulated in the "Standards for Chinese Herbal Pieces in Yunnan Province" (YPBZ-0196-2013), and Dendrobium powder is in accordance with the regulations in "Chinese Pharmacopoeia" (2010 edition). Quality standards for preparation and quality inspection. Rupi Sanjie capsules were purchased from Jiangxi Deshang Pharmaceutical Co., Ltd., estradiol benzoate injection was purchased from Tia...

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Abstract

The invention discloses a dragon tree leaf / dendrobe pharmaceutical composition, and a preparation method, preparation and application thereof, belonging to the technical field of preparation of medicines. The pharmaceutical composition comprises 45-55 parts by weight of dragon tree leaf ultrafine powder and 45-55 parts by weight of dendrobe ultrafine powder. The preparation method comprises the following steps: removing impurities from dragon tree leaf and dendrobe, selecting, cleaning, airing, and drying until the water content is at most 3%; respectively pulverizing the dragon tree leaf and dendrobe with a coarse pulverizer, and passing through a 100-140-mesh screen; pulverizing the dragon tree leaf coarse powder by a jet mill to obtain the ultrafine powder with the particle size of 10-15 mu m, and pulverizing the dendrobe coarse powder by a vibromill to obtain the ultrafine powder with the particle size of 6-12 mu m; and evenly mixing the 45-55 parts by weight of dragon tree leaf ultrafine powder and the 45-55 parts by weight of dendrobe ultrafine powder. The preparation is prepared by adding pharmaceutically acceptable auxiliary materials into the pharmaceutical composition. The pharmaceutical composition can be used for preparing medicines for treating hyperplasia of mammary glands and diabetes, and has the characteristics of high bioavailability, high active component leaching speed and favorable drug absorption effect.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to a medicinal composition of leaves of dracaena dracaena and Dendrobium dendrobii and a preparation method, preparation and application thereof. Background technique [0002] The leaves of Dracaena dracaena are the dried leaves of the genus Dracaena in the family Liliaceae. They are rich in medicinal active ingredients, mainly including alkanes and aromatics, as well as some acids and alcohols. Traditional Chinese medicine theory believes that the leaves of dragon blood have the functions of clearing internal fire, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain. Dendrobium is the fresh or dried stem of Dendrobium, which is rich in polysaccharides, alkaloids, and fluorenones. Modern pharmacological studies have shown that Dendrobium has the effects of nourishing yin and clearing heat, nourishing the stomach, nouri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P15/14A61P3/10
Inventor 刘宝
Owner 普洱淞茂滇草六味制药股份有限公司
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