Medicament composition for preventing and treating rheumatoid arthritis and application thereof

A rheumatoid, composition technology, applied in the field of medicine, to achieve the effects of increasing safety, reducing toxic and side effects, and reducing costs

Active Publication Date: 2014-06-18
NANTONG FINC PHARMA CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, in the treatment of arthritis, there is no therapeutic drug with tetrahydropalmatine or the combination of tetrahydropalmatine and aspirin as the main active ingredient.

Method used

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  • Medicament composition for preventing and treating rheumatoid arthritis and application thereof
  • Medicament composition for preventing and treating rheumatoid arthritis and application thereof
  • Medicament composition for preventing and treating rheumatoid arthritis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Rat Adjuvant Arthritis Model Experiment

[0020] 40 SD rats, weighing 180-220 g, were routinely fed for one week, and injected 0.1 mL of complete Freund's adjuvant into the plantar part of the right hind limb of the rats to establish a pathological model of adjuvant arthritis. The successfully modeled adjuvant arthritis rats were randomly divided into four groups according to body weight, namely the model control group, the L-tetrahydropalmatine group (20 mg / kg / d), the aspirin group (10 mg / kg), and the composition group ( L-tetrahydropalmatine 20mg / kg / d + aspirin 10mg / kg / d) in total 4 groups, 10 rats in each group. On the 4th day after modeling, the rats in the L-tetrahydropalmatine group, the aspirin group, and the composition group were intragastrically administered with corresponding doses of drugs, and the model control group was intragastrically administered with the same volume of purified water, each group once a day, A total of three weeks of administ...

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Abstract

The invention discloses a medicament composition for preventing and treating rheumatoid arthritis and application thereof. The medicament composition contains tetrahydropalmatine and aspirin, wherein the weight ratio of the tetrahydropalmatine to the aspirin is (1-5):1. The medicament composition has the critical advantage of anti-inflammation in a collaborative manner, and can effectively adjust the activity of the plasma TNF-alpha and PGE2 in the tissue, thus achieving the purpose of curing rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for preventing and treating rheumatoid arthritis and its application. Background technique [0002] Arthritis refers to arthritic lesions caused by inflammation, infection, trauma or other factors. It will cause joint dysfunction to varying degrees, and the course of the disease is long, lingering and difficult to heal, and the common feature is a chronic inflammatory process of progressive development. The main clinical manifestations are joint pain, joint swelling, joint dysfunction and other symptoms, and it is one of the important causes of disability. According to statistics, there are as many as 355 million arthritis patients in the world, and more than 100 million arthritis patients in my country, and the number is still increasing. Arthritis has seriously affected life, work and study, so the development of effective arthritis t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/616A61P29/00A61P19/02A61K31/4375
Inventor 王钰凌董健
Owner NANTONG FINC PHARMA CHEM
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