A method for extracting flax lignans, the obtained extract and its application

A technology of flax lignans and extracts, which is applied in the field of extraction of flax lignans, can solve the problems of easily polluting the environment with oil residue, low extraction efficiency, and long extraction time, and achieve simple and reasonable refining methods, high content, and production low cost effect

Inactive Publication Date: 2017-01-04
孙晋华 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the extraction time is long, the extraction efficiency is not high, the use of organic solvents is easy to pollute the environment, and the oil residue after extraction is no longer suitable for use as livestock feed. Impurity removal, there are disadvantages such as high production cost

Method used

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  • A method for extracting flax lignans, the obtained extract and its application
  • A method for extracting flax lignans, the obtained extract and its application
  • A method for extracting flax lignans, the obtained extract and its application

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Embodiment

[0029] Take linseed, press or extract, filter oil residue to get dry oil residue, take 1000g, add 16 times the amount of 70% ethanol to extract 3 times, each time for 1 hour, combine the extracts, concentrate to 2g raw medicinal materials / ml, refrigerate for 24 hours, filter, take the filtrate, centrifuge (5000 rpm), take the centrifugate, use a membrane with a molecular weight cut-off of 100,000 for ultrafiltration, take the ultrafiltrate, and add it to the treated liquid at a speed of 1BV / h On the D101 macroporous resin, wash with water until the effluent is colorless, then use 20% and 30% ethanol to elute at a speed of 2BV / h until the eluate is colorless, collect and combine the 20% and 30% ethanol eluents , concentrated under reduced pressure, dried, and obtained. The three batches of intermediates obtained by this method contain 91.3%, 91.8% and 91.2% of flax lignans respectively.

[0030] In order to obtain a relatively ideal preparation process, the present invention ...

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Abstract

The invention discloses a method for extracting secoisolariciresinol diglucoside, an obtained extract and use of the extract. The method comprises the following steps: extracting linseed oil dregs with 70% ethanol, and concentrating, filtering and centrifugalizing; ultrafiltering; adding ultrafiltrate into macroporous resin to be washed, and sequentially eluting with 20% and 30% ethanol to colorless; and collecting and combining the eluant, decompressing and concentrating and drying to obtain. The method has the advantages that 1) the process is simple; 2) the extracting solvent is low in price and available; 3) impurities are not removed by acid and alkali treatment, and the refining method is simpler and more reasonably and low in production cost; 5) the obtained intermediate is high in content of secoisolariciresinol diglucoside; 6) the obtained extract has the effect of treating woman climacteric syndrome and can be clinically applied, and the extracted linseed oil dregs still can be used as feed for livestock, thereby greatly improving the comprehensive utilization value of the oil dregs.

Description

technical field [0001] The invention relates to a method for extracting linseed lignans from linseed oil residue, the obtained extract and its application. Background technique [0002] Linseed oil residue is the oil residue obtained after pressing or extracting the vegetable oil contained in flax oil seeds. It is currently used as livestock feed in the production area. It is found through experiments that linseed oil residue contains physiologically active substances represented by linseed lignans, which have the effect of treating menopausal syndrome in women. At present, the extraction methods and solvents of flax lignans are reported to use chloroform to degrease and then use ethanol and dioxane as a mixed solvent for cold extraction, or grind the raw materials and add ethanol for cold extraction and organic solvent extraction to remove impurities. . However, the extraction time is long, the extraction efficiency is not high, the use of organic solvents is easy to poll...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/18C07H1/08A61K36/55A61P15/12
Inventor 孙晋华刘涛
Owner 孙晋华
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