35results about How to "The refining method is simple" patented technology

The invention relates to a method for extracting luteolin and beta-sitosterol from peanut shells. The method comprises the following steps: taking the peanut shells as materials, cleaning the peanut shells to remove impurities, crushing the cleaned peanut shells, performing extraction on the crushed peanut shells by an ethanol solution, carrying out filtration, decolorization and concentration under reduced pressure to obtain a luteolin and beta-sitosterol mixture, then mixing the luteolin and beta-sitosterol mixture with an alkali liquor, after that, carrying out extraction separation to obtain beta-sitosterol, performing extraction after pH adjustment to obtain a luteolin crude product, and performing alcohol dissolution, crystallization and recrystallization on the crude product to obtain a luteolin product with relatively high purity. The method is simple to operate, demands less on equipment, lowers the manufacturing cost of luteolin and reduces the risk of environmental pollution.

The present invention discloses the paraffin adsorption refining method with waste hydrofining catalyst. The waste hdyrofining catalyst is first treated to form paraffin refining adsorbent. The refining process may be intermittent or continuous one with refining temperature of 90-200 deg.C and space velocity 0.1-5.0 / hr. The adsorbent may be regenerated. The said process may be used alone for refining paraffin, or cooperated with hydrofining process as the pre-treatment for hydrofining material paraffin resulting in prolonged service life of hydrogenation catalyst.

The invention relates to a method for purifying high-purity cariprazine. The crude cariprazine is added to dichloromethane and alcohol, heated and stirred until dissolved, and then an ester solvent or a ketone solvent is added; The oxazine crystals were washed with ethyl acetate and dried in vacuo to obtain high-purity cariprazine. The yield of cariprazine in the purification method is above 80%, the purity (HPLC) reaches 99.5%, and the impurities are reduced to about 0.1%.

The invention provides a preparation method suitable for industrially producing oteracil potassium. The method provided by the invention has the advantages that: reaction steps are fewer, oxidants which generate gases polluting the environment are not used, a refining method is simple, the consumption of organic solvents which are harmful to the human body is decreased, the cost is saved, the total yield can reach more than 65%, and the method is suitable for the industrial production; the purity of a product reaches more than 99.8%, the impurity content of the single product is less than 0.1% and the purity and the impurity of the product both reach quality standards for the raw material medicine; and the obtained product is the oteracil potassium raw material medicine which is suitable for preparation of a medicinal preparation.

The invention provides a method for purifying S-3-cyclohexenecarboxylic acid, the specific steps comprising: mixing crude S-3-cyclohexenecarboxylic acid, R-a-phenethylamine and ethyl acetate, stirring under reflux, filtering Obtain S-3-cyclohexenecarboxylic acid-R-a-phenethylamine salt, wherein, described S-3-cyclohexenecarboxylic acid crude product refers to the S-3-cyclohexenecarboxylic acid with ee value less than 97%; The S-3-cyclohexenecarboxylic acid-R-a-phenethylamine salt and ethanol are mixed, crystallized and filtered to obtain a recrystallized material; methylene chloride, water and the recrystallized material are mixed and stirred, and the The organic layer is collected after the liquid, and the organic layer is subjected to distillation treatment to obtain S-3-cyclohexenecarboxylic acid. The method for purifying S-3-cyclohexenecarboxylic acid provided by the invention can make the ee value of the prepared S-3-cyclohexenecarboxylic acid reach more than 99%, and simultaneously the resolving agent R-phenethylamine is recycled ,save costs.

The invention relates to a refining method of Shugeng sodium gluconate. A crude Shugeng sodium gluconate is purified by using a microreactor. Compared with the prior art, the refining method has the following beneficial technical effects: 1) the refining method of Shugeng sodium gluconate is simple and easy, and lower in energy consumption; 2) the refining method of Shugeng sodium gluconate is shorter in consumption time compared with the existing methods; and 3) the purity of the Shugeng sodium gluconate prepared by using the refining method is not lower than 98.0%, and the yield is not lower than 85%.

The invention discloses a novel method for refining methyl chloroacetate, and belongs to the technical field of organic synthesis. By means of the method, a crude methyl chloroacetate product generated through an esterification reaction of methanol and chloroacetic acid is subjected to freezing layering to separate chloroacetic acid and a water layer. According to the refining method, the purity of methyl chloroacetate can reach 99.4% or above only by simply freezing the crude methyl chloroacetate product to minus 15 DEG C without simple distillation or rectification, little time is needed, the production time is greatly shortened, the production cost is greatly reduced, and the green chemical industry requirements are met.

The invention provides a method for preparing and refining bromfenac sodium which is mild in reaction conditions, simple in operation, high in purity, high in yield, low in cost and easy for industrial production.

The invention discloses a refining method for tetracycline. The method comprises the following steps: (1) adding crude tetracycline into an acid solvent, and adding an acid precipitant and borax for dissolving to obtain a mixture A; (2) adjusting the pH of the mixture A to 1.2-2.8, standing the mixture A, and filtering the mixture A to obtain filtrate A; (3) adding zinc sulfate, potassium ferrocyanide and active carbon into the filtrate A to obtain a mixture B, standing the mixture B, and filtering the mixture B to obtain filtrate B; (4) performing ultrafiltration on the filtrate B to obtain filtrate C, adjusting the pH of the filtrate C to 4.5-5.0, standing the filtrate C, and filtering the filtrate C to obtain a filter cake A; (5) taking the filter cake A out, dissolving the filter cake A by using the acid solvent, adjusting the pH of the dissolved filter cake A to 4.5-5.0, standing the dissolved filter cake A, and filtering the dissolved filter cake A to obtain a filter cake B; and (6) drying the filter cake B in vacuum to obtain refined tetracycline. The refining method disclosed by the invention has the advantages of high product yield, high product purity, easiness and feasibility in operation, need of simple equipment, adoption of cheap and readily-available raw materials and low cost, and is suitable for large-scale industrial production.

The present invention is applicable to the technical field of medicine and chemical industry, and provides a method for refining thymol, comprising: adding a refining solvent to the crude thymemol, heating and stirring sufficiently to obtain a first mixed solution; the amount of the refining solvent is 0.5~3 times of the mass-volume ratio of the thymemol crude product; add an adsorbent to the first mixed solution, carry out heat preservation and decolorization treatment, and obtain the second mixed solution; filter the second mixed solution, and obtain The filtrate is subjected to cooling crystallization, heat preservation crystallization, cooling crystallization, and rejection filtration to obtain the filtrate. The refining method of the present invention can refine the impurities such as citronellal and isopulegol in the crude product of thymol to almost no detection, effectively improve the product purity, and meet the requirements of medicine; at the same time, compared with the traditional rectification method, the present invention The refining method is simple, and the refining cost is greatly reduced.

The invention discloses a capsanthin residue refining method and belongs to the field of plant extraction. The capsanthin residue refining method comprises freezing and weak alkaline solution treatment. The capsanthin residue refining method can reduce the content of phospholipid, wax, pectin and polysaccharides in capsanthin residues; refined capsanthin residues have the advantages of being goodin mobility and free from solidification at low temperature; the capsanthin residue refining method is simple and applicable large-scale industrialized production.

The invention discloses a method for refining oxytetracycline. The method particularly comprises the following steps: 1) dissolving coarse oxytetracycline into hydrochloric acid; 2) adding ammonium thiocyanate, dissolving with stirring, adjusting the pH value of the solution, standing for 1 hour and then filtering impurities; 3) adding potassium hexacyanoferrate-zinc sulfate scavenging agent into the filtrate, standing for 2 hours and then filtering impurities; 4) performing ultrafiltration on the filtrate; 5) adjusting the pH value of the ultrafiltrate to be 4.5-5.0, standing for 4 hours and then filtering to obtain crystal; 6) dissolving the crystal with hydrochloric acid adjusting the pH value to be 4.5-5.0, standing for 4 hours and then filtering to obtain crystal; and 7) carrying out vacuum-drying on the crystal to obtain the refined oxytetracycline. The method for refining the oxytetracycline is simple and low in cost. The prepared oxytetracycline has high purity, stable physiological and biochemical characteristics, no toxic or side effect and wide application value.

The invention provides a refining method for a tofartinib citrate compound. The method comprises the following steps: preparing a tofartinib citrate crude product by a tofartinib crude product and citric acid monohydrate; adding a prepared mixed solvent, heating and stirring the mixture to be completely dissolved to obtain a clear solution, adding activated carbon, performing keeping warm and stirring, performing filtering, cooling a filtrate and performing recrystallization, performing filtering, washing a filter cake, and performing vacuum drying to obtain a tofatinib citrate refined product. The refining method has simple operation and high yield, the purity of tofartinib citrate reaches 99.93% or more, the maximum single impurity content is controlled to be 0.06% or less, and the totalimpurity content is controlled to be within 0.08%.