35results about How to "The refining method is simple" patented technology

The invention relates to a method for extracting luteolin and beta-sitosterol from peanut shells. The method comprises the following steps: taking the peanut shells as materials, cleaning the peanut shells to remove impurities, crushing the cleaned peanut shells, performing extraction on the crushed peanut shells by an ethanol solution, carrying out filtration, decolorization and concentration under reduced pressure to obtain a luteolin and beta-sitosterol mixture, then mixing the luteolin and beta-sitosterol mixture with an alkali liquor, after that, carrying out extraction separation to obtain beta-sitosterol, performing extraction after pH adjustment to obtain a luteolin crude product, and performing alcohol dissolution, crystallization and recrystallization on the crude product to obtain a luteolin product with relatively high purity. The method is simple to operate, demands less on equipment, lowers the manufacturing cost of luteolin and reduces the risk of environmental pollution.

The invention provides a preparation method suitable for industrially producing oteracil potassium. The method provided by the invention has the advantages that: reaction steps are fewer, oxidants which generate gases polluting the environment are not used, a refining method is simple, the consumption of organic solvents which are harmful to the human body is decreased, the cost is saved, the total yield can reach more than 65%, and the method is suitable for the industrial production; the purity of a product reaches more than 99.8%, the impurity content of the single product is less than 0.1% and the purity and the impurity of the product both reach quality standards for the raw material medicine; and the obtained product is the oteracil potassium raw material medicine which is suitable for preparation of a medicinal preparation.

The invention provides a preparation and refining method of bromfenac sodium. The method has the advantages that the reaction conditions are mild, the operation is simple, and the obtained product is high in purity, high in yield and low in cost and can be industrially produced easily.

Provided is a method for preparing 9-fluorenone through fluorine. The industrial fluorine is adopted as raw materials, the 9-fluorenone and water are adopted as solvents, alkali is adopted as catalysts, quaternary ammonium salt is adopted as phase transfer agents, oxygen-containing gas is piped in as oxidizing agents, the 9-fluorenone is synthetised at the reaction temperature of 70 DEG C to 83 DEG C, and the raw materials of the fluorine are added at one time or constantly replenished along with the reaction. The products, 9-fluorenone, are adopted as solvents, the process of solvent fluorenone separation, recycling and the like is eliminated, reaction liquid separation and 9-fluorenone purification are operated in a coupling mode, and the 9-fluorenone synthetic process is greatly simplified. The alkali, the quaternary ammonium salt and the by-product, water, are all recycled. Through the fluorine replenishing feeding mode, the utilization efficiency of a reactor is improved.

The invention provides a refining method for a tofartinib citrate compound. The method comprises the following steps: preparing a tofartinib citrate crude product by a tofartinib crude product and citric acid monohydrate; adding a prepared mixed solvent, heating and stirring the mixture to be completely dissolved to obtain a clear solution, adding activated carbon, performing keeping warm and stirring, performing filtering, cooling a filtrate and performing recrystallization, performing filtering, washing a filter cake, and performing vacuum drying to obtain a tofatinib citrate refined product. The refining method has simple operation and high yield, the purity of tofartinib citrate reaches 99.93% or more, the maximum single impurity content is controlled to be 0.06% or less, and the totalimpurity content is controlled to be within 0.08%.

The invention relates to a fatty acid amide propyl dimethylamine refining method. The molecular structure of the fatty acid amide propyl dimethylamine is shown in the following specification, wherein n is 7-23. The fatty acid amide propyl dimethylamine refining method is characterized by comprising the steps of step 1, on the basis of the synthesis process of fatty oil or vegetable oil, or animal oil, or fatty acid methyl ester and dimethylamino-1-propylamine, in the process of adding materials, adding 0.01-0.05% (the weight of the fatty oil or vegetable oil, or animal oil, or fatty acid methyl ester) of a reducing catalyst such as one or several of sodium sulfite, sodium borohydride, sodium hypophosphite, making the mixture react under original process condition, step 2, before discharging products, dropwise adding 0.3-0.5 time of original theoretical amount of dimethylamino-1-propylamine, under the original process condition continuing reaction for 0.5-2 hours, step 3, under the reaction temperature, increasing the flow of inert gas such as nitrogen gas to blow and wash from a reactor bottom until no dimethylamino-1-propylamine can be tested in tail gas, complete the refining to acquire the high quality fatty acid amide propyl dimethylamine.

The invention belongs to the field of medicine impurities, and particularly relates to a delafloxacin impurity IV and a product refining method. A proper analysis method is selected through optimization to detect related stubborn impurities of a product. The specific structure of related impurities is separated, detected and confirmed. Finally, synthesis and process routes are optimized, impurities are controlled within a safe range, a basis is provided for product process amplification, stability, quality, pharmacology and toxicology and clinical research, and the method has important significance in reducing the safety risk of drug impurities.

The invention discloses a novel method for refining methyl chloroacetate, and belongs to the technical field of organic synthesis. By means of the method, a crude methyl chloroacetate product generated through an esterification reaction of methanol and chloroacetic acid is subjected to freezing layering to separate chloroacetic acid and a water layer. According to the refining method, the purity of methyl chloroacetate can reach 99.4% or above only by simply freezing the crude methyl chloroacetate product to minus 15 DEG C without simple distillation or rectification, little time is needed, the production time is greatly shortened, the production cost is greatly reduced, and the green chemical industry requirements are met.

The invention provides a pentane refining method. The pentane refining method comprises the following steps: mixing a pentane raw material and a metal-modified HZSM-5 molecular sieve, and refining toobtain refined pentane, wherein in the metal-modified HZSM-5 molecular sieve, modifying metal is copper or silver. According to the invention, the metal-modified HZSM-5 molecular sieve is used as a pentane refining agent, the refining method is simple, the energy consumption is low, and after refining, the content of unsaturated hydrocarbon is lower than 10 ppm; in addition, the pentane refining agent provided by the invention is recyclable, a pentane product obtained after recycling meets index requirements of the unsaturated hydrocarbon, the recycling condition is mild, and the recycling time is short.

The invention relates to a refining method of high-purity cariprazine. The refining method comprises the following steps: adding dichloromethane and alcohol into a cariprazine crude product, heating and stirring until the crude product is dissolved, adding an ester solvent or a ketone solvent; cooling, crystallizing, filtering, collecting cariprazine crystals, washing cariprazine crystals by ethylacetate, and drying cariprazine crystals in vacuum to obtain high-purity cariprazine. According to the refining method, the yield of cariprazine is 80% or above, the purity (HPLC) reaches 99.5%, andthe impurity content is reduced to about 0.1%.