Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Refining method of Shugeng sodium gluconate

A refining method and sodium dextrose technology are applied in the field of medicine, can solve the problem of low product yield and the like, and achieve the effects of low energy consumption, short time consumption, and simple and easy refining method

Active Publication Date: 2017-11-07
ZIBO QIANHUI BIOTECH
View PDF9 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the activated carbon adsorption process, part of sugammadex sodium was adsorbed into the micropores of activated carbon together with impurities, resulting in low product yield.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The crude sugammadex sodium was purified using a microreactor. The microreactor is a T-type mixer. The two inlets of the T-type mixer communicate with the containers A and B through the horizontal flow pumps a and b respectively, and the outlet communicates with the receiving vessel C; the microchannel size of the T-type mixer is length = 30mm; width = 0.3mm; height = 0.5 mm. Prepare sugammadex sodium crude product into a distilled aqueous solution with a concentration of 3.0g / 10mL, and put it into container A; put analytically pure ethanol into container B. The process conditions are as follows: the reaction temperature of the T-type mixer is 50 ° C; the flow rate of the advection pump a is 3 mL / min, and the flow rate of the advection pump b is 30 mL / min; the residence time is 240 s. The mixed suspension is finally received in container C. After it was cooled to room temperature, it was suction filtered and dried to obtain a white solid, namely pure sugammadex sodiu...

Embodiment 2

[0039] The crude sugammadex sodium was purified using a microreactor. The microreactor is a T-type mixer. The two inlets of the T-type mixer communicate with the containers A and B through the horizontal flow pumps a and b respectively, and the outlet communicates with the receiving vessel C; the microchannel size of the T-type mixer is length = 30mm; width = 0.3mm; height = 0.5 mm. Prepare sugammadex sodium crude product into a distilled aqueous solution with a concentration of 4.0g / 10mL, and put it into container A; put ethanol of analytical grade into container B. The process conditions are as follows: the reaction temperature of the T-type mixer is 60 ° C; the flow rate of the advection pump a is 4 mL / min, and the flow rate of the advection pump b is 40 mL / min; the residence time is 180 s. The mixed suspension is finally received in container C. After it was cooled to room temperature, it was suction filtered and dried to obtain a white solid, namely pure sugammadex sod...

Embodiment 3

[0041]The crude sugammadex sodium was purified using a microreactor. The microreactor is a T-type mixer. The two inlets of the T-type mixer communicate with the containers A and B through the horizontal flow pumps a and b respectively, and the outlet communicates with the receiving vessel C; the microchannel size of the T-type mixer is length = 30mm; width = 0.3mm; height = 0.5 mm. Prepare sugammadex sodium crude product into a distilled aqueous solution with a concentration of 3.5g / 10mL, and put it into container A; put ethanol of analytical grade into container B. The process conditions are as follows: the reaction temperature of the T-type mixer is 55 ° C; the flow rate of the advection pump a is 3 mL / min, and the flow rate of the advection pump b is 35 mL / min; the residence time is 200 s. The mixed suspension is finally received in container C. After it was cooled to room temperature, it was suction filtered and dried to obtain a white solid, namely pure sugammadex sodi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
purityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a refining method of Shugeng sodium gluconate. A crude Shugeng sodium gluconate is purified by using a microreactor. Compared with the prior art, the refining method has the following beneficial technical effects: 1) the refining method of Shugeng sodium gluconate is simple and easy, and lower in energy consumption; 2) the refining method of Shugeng sodium gluconate is shorter in consumption time compared with the existing methods; and 3) the purity of the Shugeng sodium gluconate prepared by using the refining method is not lower than 98.0%, and the yield is not lower than 85%.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a method for refining chemical drugs, in particular to a method for refining sugammadex sodium. Background technique [0002] Sugammadex sodium (Sugammadex sodium) is a structurally modified gama-cyclodextrin developed by Merck Pharmaceuticals, and it has become the first selective antagonist of steroidal muscle relaxants. Sugammadex Sodium was first launched in Sweden in 2008 for the reversal of muscle relaxation symptoms caused by rocuronium bromide or vecuronium bromide; in 2015, it obtained the US FDA batch number, and the trade name was Brittin. [0003] Sugammadex sodium is obtained by replacing all the 6-position hydroxyl groups in the 8 glucopyranose units of gama-cyclodextrin with carboxyethylthio groups. The synthesis method of sugammadex sodium reported at present all comprises two steps: first carry out halogenation reaction by gama-cyclodextrin and obtain 6-perdeo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/16
Inventor 王丽萍毕方玉许维成王哲
Owner ZIBO QIANHUI BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com