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Refining method of sugammadex sodium

A technology of sodium glucose and refining methods, which is applied in the field of medicine, can solve the problems of low product yields, and achieve the effects of low energy consumption, simple and easy refining methods, and short time consumption

Active Publication Date: 2019-09-17
ZIBO QIANHUI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the activated carbon adsorption process, part of sugammadex sodium was adsorbed into the micropores of activated carbon together with impurities, resulting in low product yield.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The crude sugammadex sodium was purified using a microreactor. The microreactor is a T-type mixer. The two inlets of the T-type mixer communicate with the containers A and B through the horizontal flow pumps a and b respectively, and the outlet communicates with the receiving vessel C; the microchannel size of the T-type mixer is length = 30mm; width = 0.3mm; height = 0.5 mm. Prepare sugammadex sodium crude product into a distilled aqueous solution with a concentration of 3.0g / 10mL, and put it into container A; put analytically pure ethanol into container B. The process conditions are as follows: the reaction temperature of the T-type mixer is 50 ° C; the flow rate of the advection pump a is 3 mL / min, and the flow rate of the advection pump b is 30 mL / min; the residence time is 240 s. The mixed suspension is finally received in container C. After it was cooled to room temperature, it was suction filtered and dried to obtain a white solid, namely pure sugammadex sodiu...

Embodiment 2

[0039] The crude sugammadex sodium was purified using a microreactor. The microreactor is a T-type mixer. The two inlets of the T-type mixer communicate with the containers A and B through the horizontal flow pumps a and b respectively, and the outlet communicates with the receiving vessel C; the microchannel size of the T-type mixer is length = 30mm; width = 0.3mm; height = 0.5 mm. Prepare sugammadex sodium crude product into a distilled aqueous solution with a concentration of 4.0g / 10mL, and put it into container A; put ethanol of analytical grade into container B. The process conditions are as follows: the reaction temperature of the T-type mixer is 60 ° C; the flow rate of the advection pump a is 4 mL / min, and the flow rate of the advection pump b is 40 mL / min; the residence time is 180 s. The mixed suspension is finally received in container C. After it was cooled to room temperature, it was suction filtered and dried to obtain a white solid, namely pure sugammadex sod...

Embodiment 3

[0041]The crude sugammadex sodium was purified using a microreactor. The microreactor is a T-type mixer. The two inlets of the T-type mixer communicate with the containers A and B through the horizontal flow pumps a and b respectively, and the outlet communicates with the receiving vessel C; the microchannel size of the T-type mixer is length = 30mm; width = 0.3mm; height = 0.5 mm. Prepare sugammadex sodium crude product into a distilled aqueous solution with a concentration of 3.5g / 10mL, and put it into container A; put ethanol of analytical grade into container B. The process conditions are as follows: the reaction temperature of the T-type mixer is 55 ° C; the flow rate of the advection pump a is 3 mL / min, and the flow rate of the advection pump b is 35 mL / min; the residence time is 200 s. The mixed suspension is finally received in container C. After it was cooled to room temperature, it was suction filtered and dried to obtain a white solid, namely pure sugammadex sodi...

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PUM

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Abstract

The invention relates to a refining method of Shugeng sodium gluconate. A crude Shugeng sodium gluconate is purified by using a microreactor. Compared with the prior art, the refining method has the following beneficial technical effects: 1) the refining method of Shugeng sodium gluconate is simple and easy, and lower in energy consumption; 2) the refining method of Shugeng sodium gluconate is shorter in consumption time compared with the existing methods; and 3) the purity of the Shugeng sodium gluconate prepared by using the refining method is not lower than 98.0%, and the yield is not lower than 85%.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a method for refining chemical drugs, in particular to a method for refining sugammadex sodium. Background technique [0002] Sugammadex sodium (Sugammadex sodium) is a structurally modified gama-cyclodextrin developed by Merck Pharmaceuticals, and it has become the first selective antagonist of steroidal muscle relaxants. Sugammadex Sodium was first launched in Sweden in 2008 for the reversal of muscle relaxation symptoms caused by rocuronium bromide or vecuronium bromide; in 2015, it obtained the US FDA batch number, and the trade name was Brittin. [0003] Sugammadex sodium is obtained by replacing all the 6-position hydroxyl groups in the 8 glucopyranose units of gama-cyclodextrin with carboxyethylthio groups. The synthesis method of sugammadex sodium reported at present all comprises two steps: first carry out halogenation reaction by gama-cyclodextrin and obtain 6-perdeo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/16
Inventor 王丽萍毕方玉许维成王哲
Owner ZIBO QIANHUI BIOTECH
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