Antimicrobial mixture of aldehydes, organic acids and organic acid esters

An organic acid ester, antimicrobial technology, used in food ingredients as antimicrobial preservation, chemicals for biological control, biocides, etc.

Active Publication Date: 2014-07-30
ANITOX CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The combination of trans-2-hexenal with an organic acid ester has not been suggested or observed in the prior art to improve the antimicrobial activity of either component by itself

Method used

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  • Antimicrobial mixture of aldehydes, organic acids and organic acid esters
  • Antimicrobial mixture of aldehydes, organic acids and organic acid esters
  • Antimicrobial mixture of aldehydes, organic acids and organic acid esters

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Organic acid methyl esters and organic acid ethyl esters were added to the test tubes at concentrations of 0.01% and 0.05%. The tube was vortexed for 10 seconds to mix the solution evenly. A suspension of Salmonella typhimurium (ATCC: 14028) was added to each test tube to obtain 10 4 Final concentration of cfu / ml. The solution was vortexed, then incubated at room temperature for 24 hours, and plated onto XLT-4 agar. Plates were incubated at 37°C for 48 hours before colonies were counted. The potency of each ester is shown in Table 1 below as a percent reduction compared to the control value.

[0113]

[0114] *ND not determined

[0115] Observed: chain length C 4 ~C 8 Esters of organic acids were effective against Salmonella at the concentrations tested. Ethyl esters are generally more effective than methyl esters. Esters of benzoic acid (aromatic cyclic acid) and isoamyl acetate (isoamyl ester of acetic acid) were also observed to have fungicidal activity. ...

Embodiment 2

[0117] As shown in Table 2 below, eight kinds of organic acid esters (C 4 ~C 8 organic acid esters and benzoates) mixed with trans-2-hexenal, nonanoic acid, propionic acid, acetic acid and water. A 25% hexanal:organic acid product (Recipe 1) and formic acid:propionic acid (90:10, F / P) product were included as positive controls. The formulations were added to test tubes at concentrations of 0.01% and 0.005%. The tubes were vortexed for 10 seconds to mix the solution evenly.

[0118]

[0119] Salmonella typhimurium (10 4 cfu / ml) to tubes containing different dilutions of each formulation. The solution was vortexed, then incubated at room temperature for 24 hours, and plated onto XLT-4 agar. Plates were incubated at 37°C for 48 hours before colonies were counted.

[0120] The potency of each formulation is shown in Tables 3 to 10 below as a percent reduction compared to the control value.

[0121]

[0122]

[0123]

[0124]

[0125]

[0126]

[0127] ...

Embodiment 3

[0133] Eighteen formulations were prepared for the in vitro studies shown in Table 11. 25% trans-2-hexenal:organic acid product (Recipe 1) and formic acid:propionic acid (90:10, F / P) product were included as positive controls. The formulations were added to test tubes at concentrations of 0.005% and 0.01%. The tube was vortexed for 10 seconds to mix the solution evenly.

[0134]

[0135] Salmonella typhimurium (10 4 cfu / ml) to tubes containing different dilutions of each formulation. The solution was vortexed, then incubated at room temperature for 24 hours, and plated onto XLT-4 agar. Plates were incubated at 37°C for 48 hours before colonies were counted. The potency of each formulation is shown in Table 12 below as a percent reduction compared to the control value.

[0136]

[0137]

[0138] Addition of 5% of each ester to an organic acid product containing 20% ​​trans-2-hexenal was equivalent in efficacy to an organic acid product containing 25% trans-2-hexen...

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Abstract

An antimicrobial composition and method for extending the shelf-life of water, food / feed food / feed ingredients, comprising: 5 - 25 wt. % nonanoic acid, 1 - 25 wt.% organic acid ester, 1 - 50 wt. % of a single or mixture of C1-C24 aldehydes, a mixture of C1-C24 organic acids, and water.

Description

technical field [0001] An antimicrobial formulation comprising a mixture of an organic acid, an aldehyde, and an organic acid ester, the combination in the antimicrobial formulation producing a synergistic response. Background technique [0002] The Centers for Disease Control and Prevention (CDC) estimates that approximately one in six Americans, or 48 million people, become ill each year due to foodborne illness. Additionally, 128,000 people are hospitalized each year and approximately 3,000 die from foodborne illness. In 2011, the CDC (http: / / www.cdc.gov / outbreaknet / foodborne-surveillance-questions-and-answers.html) estimated that salmonellosis causes 20,000 hospitalizations and 378 deaths annually. Also, Escherichia coli O157:O7 is estimated to cause about 62,000 cases of foodborne illness and about 1800 foodborne illness-related hospitalizations in the United States each year. Research by the Pew Charitable Trusts of Georgetown University shows that foodborne illnesse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L3/34A23L3/3463A23L3/3481A23L3/3508A23L3/3517A01N35/02A01N37/02C02F1/50A01P1/00
CPCA01N35/02A01N37/02A01N37/10A23L3/34A23L3/3463A23L3/3481A23L3/3508A23L3/3517C02F1/50A23V2002/00A23V2200/10A01N2300/00A23L3/34635
Inventor 胡里奥·皮门特尔库尔特·理查森
Owner ANITOX CORP
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