Dahurian rose fruit dispersible tablet and preparation method thereof

A technology of thorn rose fruit and dispersible tablets, applied in the field of medicine, can solve the problems of coronary heart disease and the like

Active Publication Date: 2014-09-17
JILIN INST OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no special medicine for coronary heart disease at home and abroad. Western medicine tends to improve symptoms, and the side effects are relatively obvious. In terms of traditional Chinese medicine treatment, reasonable prescriptions and medicines are formulated according to the theory of traditional Chinese medicine, which has a good clinical effect on the treatment of cardiovascular and cerebrovascular diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] a. Preparation process of traditional Chinese medicine: take 2000g of Rosa thorn fruit, add 10 times the amount of 70% ethanol to reflux for extraction for 5 hours, filter, and the filtrate for later use; add water to the residue and decoct twice, the first time for 4 hours, the second time for 2 hours, filter, Combine the filtrates, recover ethanol, concentrate to a clear paste with a relative density of 1.14-1.20 (60°C), add distilled water to disperse to a concentration of 0.025-0.035 g / mL (equivalent to the original drug), and adjust the pH of the liquid to 2.0-4.0 , after 30 min of D-101 macroporous adsorption resin, the adsorption rate is 1 BV / h, after adsorption, it is eluted with 3 BV of distilled water, and then 3 BV of 70% ethanol is used for elution at a flow rate of 1 BV / h. Collect the eluate, concentrate, dry in vacuum to form a dry paste, and crush the dry paste into fine powder;

[0023] b. Grinding the dry extract of thorn rose fruit, diluent microcrysta...

Embodiment 2

[0028] a. Preparation process of traditional Chinese medicine: take 2000g of thorn rose fruit, add 10 times the amount of 70% ethanol to reflux extraction for 5 hours, filter, and use the filtrate for later use; add water to the residue and decoct twice, the first time for 4 hours, the second time for 2 hours, filter, Combine the filtrates, recover ethanol, concentrate to a clear paste with a relative density of 1.14-1.20 (60°C), add distilled water to disperse to a concentration of 0.025-0.035 g / mL (equivalent to the original drug), and adjust the pH of the liquid to 2.0-4.0 , after 30 min of D-101 macroporous adsorption resin adsorption time, the adsorption rate is 1 BV / h, after adsorption, it is eluted with 3 BV distilled water, and then 3 BV of 70% ethanol is used for elution at a flow rate of 1 BV / h. Collect the eluate, concentrate, dry in vacuum to form a dry paste, and crush the dry paste into fine powder;

[0029] b. Pass the dry extract of rose thorn fruit, diluent mi...

Embodiment 3

[0034] a. Preparation process of traditional Chinese medicine: take 2000g of Rosa thorn fruit, add 10 times the amount of 70% ethanol to reflux for extraction for 5 hours, filter, and the filtrate for later use; add water to the residue and decoct twice, the first time for 4 hours, the second time for 2 hours, filter, Combine the filtrates, recover ethanol, concentrate to a clear paste with a relative density of 1.14-1.20 (60°C), add distilled water to disperse to a concentration of 0.025-0.035 g / mL (equivalent to the original drug), and adjust the pH of the liquid to 2.0-4.0 , after 30 min of D-101 macroporous adsorption resin, the adsorption rate is 1 BV / h, after adsorption, it is eluted with 3 BV of distilled water, and then 3 BV of 70% ethanol is used for elution at a flow rate of 1 BV / h. Collect the eluate, concentrate, dry in vacuum to form a dry paste, and crush the dry paste into fine powder;

[0035] b. Raw material dry extract of thorn rose fruit, diluent microcrysta...

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PUM

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Abstract

The invention discloses a dahurian rose fruit dispersible tablet and a preparation method thereof. The dispersible tablet is prepared from a raw material, namely an extract obtained by extracting and purifying dahurian rose fruits, diluents such as lactose, microcrystalline cellulose and calcium sulfate, disintegrating agents including cross-linked polyvinylpyrrolidone, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose, a lubricant aerosol, a corrigent stevioside, and a binder namely the ethanol solution of 5-10% polyvinylpyrrolidone K30 or 95% ethanol; the dispersible tablet is completely disintegrated in 3 minutes in a homodisperse state; the dispersible tablet has the characteristics of high disintegrating dissolution speed, high bioavailability and relatively simple preparation process, is suitable for industrial mass production and has the effect of managing qi and activating blood; the dispersible tablet can be applied to thoracic obstruction induced by Qi-stagnation and blood stasis, having the symptoms such as stethalgia, choking sensation in chest and labored breathing, or coronary heart disease and hyperlipidaemia having such symptoms.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a dispersible tablet of rose fruit and a preparation method thereof. Background technique [0002] Rosa thorn fruit is the dry ripe fruit of Rosaceae Rosa thorn. Mainly produced in Northeast China, North China and Inner Mongolia. Rose thorn contains flavonoids, vitamins, pectin, polysaccharides, saponins, organic acids and other chemical components. In addition, thorn rose fruit also contains 16 kinds of amino acids, 28 kinds of minerals, tannin, fatty oil and other ingredients. Pharmacological experiments show that the water extract and alcohol extract of rose fruit can reduce the blood pressure and cerebrovascular resistance of anesthetized rats, slow down the heart rate of anesthetized cats, increase coronary artery flow, and reduce coronary artery resistance; Oxygen content and prolonging the survival time of hypoxic mice, and can resist the effect of isoproterenol on inc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61K9/20A61K47/38A61K47/36A61K47/26A61K47/32A61P9/10A61P3/06
Inventor 王晓林钟方丽薛健飞陈帅金刚杨扬
Owner JILIN INST OF CHEM TECH
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