Ingestion method of creatine composition, creatine composition used in the ingestion method, and creatine-containing medicine and food prepared using the creatine composition
A kind of composition, the technology of creatine phosphate, applied in the field of creatine composition
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Embodiment 1
[0056] [Example 1] Based on the reaction of creatine aqueous solution and hydrochloric acid at various temperatures whether hydrogen cyanide gas is produced
[0057] As mentioned above, it is presumed that the creatine composition ingested in the body reacts with gastric acid in the body to generate hydrogen cyanide gas, and further, it is presumed that it is also somewhat related to the temperature of the water in which the creatine composition is dissolved.
[0058] Therefore, in order to verify the above speculation, a creatine composition was dissolved in water at various temperatures, and a reaction experiment between creatine and hydrochloric acid was performed.
[0059] First, in a beaker, 2 g of creatine monohydrate (hereinafter, referred to as "creatine" in Example 1) was added to 5 mL of pure water at room temperature (hereinafter, simply referred to as "water"). Acid".), stir. The normal temperature referred to here means a temperature of about 10 to 35°C. After t...
Embodiment 2
[0066] [embodiment 2] preparation of creatine test substance solution and control experiment solution
[0067] (1) Preparation of creatine test substance solution
[0068] First, in Example 2, the creatine test substance solution and the solution for the control experiment were prepared. The creatine composition and medium used when preparing the creatine test substance solution are shown in Table 2 below.
[0069] [Table 2]
[0070] Table 2. Reagents etc. used in the preparation of the creatine test substance solution prepared in embodiment 2
[0071]
[0072] The preparation of the creatine substance solution to be tested is that after weighing a necessary amount of creatine monohydrate (hereinafter referred to as "creatine powder"), the creatine powder is ground with an agate mortar, and an appropriate amount of medium is added to make it Suspended. The necessary amount referred to here refers to administering 3000 mg of creatine powder per 1 kg of guinea pigs.
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Embodiment 3
[0076] [Example 3] Preparation of reagents used in Examples 5 and 6
[0077] Next, the preparation of the antigen-containing physiological saline solution (1w / v% and 2w / v%), the metyrapone physiological saline solution and the pyrilamine maleate physiological saline solution used in Examples 5 and 6 described later Be explained.
[0078] (1) Preparation of antigen-containing physiological saline solution (1w / v% and 2w / v%)
[0079] First, as an antigen, Ovalbumin (hereinafter referred to as "OVA") from Sigma-Aldrich was used. It was prepared by weighing OVA, and then using physiological saline (manufactured by Otsuka Pharmaceutical Co., Ltd.) to prepare 1w / v% and 2w / v% OVA-containing physiological saline solutions. Regarding the preparation, it was prepared in time, that is, it was prepared at any time during each oral administration experiment (refer to Examples 5 and 6) described later.
[0080] (2) Metyrapone saline solution
[0081] As the metyrapone used, metyrapone pr...
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