Application of polysaccharide of cistanche deserticola to preparation of functional foods with effects of assistance in inhibiting colon cancer

A technology of Cistanche deserticola polysaccharide and functional food, which is applied in the field of polysaccharide and achieves the effects of stable and efficient process, low cost and simple process

Active Publication Date: 2014-10-29
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no use of cistanche as raw material to prepare polysaccharides for the preparation of auxiliary inhibition of colon cancer

Method used

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  • Application of polysaccharide of cistanche deserticola to preparation of functional foods with effects of assistance in inhibiting colon cancer
  • Application of polysaccharide of cistanche deserticola to preparation of functional foods with effects of assistance in inhibiting colon cancer
  • Application of polysaccharide of cistanche deserticola to preparation of functional foods with effects of assistance in inhibiting colon cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The Cistanche polysaccharide in this example is prepared by the following method: take the raw material of Cistanche and extract it with boiling water. For the first extraction, the amount of water used is 20 times the total mass of the raw material, boiled for 5 h and filtered; for the second extraction, The amount of water used is 20 times the total mass of raw materials, boiled for 3 h and filtered; for the third extraction, the amount of water used is 10 times the total mass of raw materials, boiled for 2 h and filtered, combined filtrates, vacuum concentrated to about 1 / of the original volume 10, the same below. The concentrated solution was treated with trichloroacetic acid to remove protein, and the same volume (the same below) of 30% trichloroacetic acid (mass percentage) was added. After the treatment time was 4 hours, it was neutralized with 10% NaOH (mass percentage), the same below, After neutralization, place the reaction solution in a dialysis bag and tie...

Embodiment 2

[0034] The polysaccharide of Cistanche in this example is prepared by the following method: take the raw material of Cistanche and extract it with boiling water. For the first extraction, the amount of water used is 15 times the total mass of the raw material of Cistanche, boil for 5 h and filter; , the amount of water used was 15 times the total mass of Cistanche raw materials, boiled for 3 h and filtered; for the third extraction, the amount of water used was 10 times the total mass of Cistanche raw materials, boiled for 3 h and filtered, combined filtrates, and concentrated in vacuo. The concentrated solution was treated with trichloroacetic acid to remove protein, and the same volume of 25% trichloroacetic acid (mass percentage) was added. After the treatment time was 3 h, it was neutralized with 10% NaOH (mass percentage). After neutralization, the reaction solution was placed in Dialyze in a dialysis bag, then concentrate the liquid in the dialysis bag, centrifuge, take t...

Embodiment 3

[0036] The polysaccharide of Cistanche in this example is prepared by the following method: take the raw material of Cistanche and extract it with boiling water. For the first extraction, the amount of water used is 10 times the total mass of the raw material of Cistanche, boil for 3 h and filter; , the amount of water used is 20 times the total mass of Cistanche raw materials, boiled for 3 h and filtered for 3 hours; for the third extraction, the amount of water used is 10 times the total mass of Cistanche raw materials, boiled for 5 h and filtered, combined filtrates, concentrated in vacuo, and concentrated solution Perform trichloroacetic acid protein removal treatment, add the same volume of 15% trichloroacetic acid (mass percentage), after a treatment time of 5 hours, neutralize with 10% NaOH (mass percentage), and place the reaction solution in a dialysis bag after neutralization Dialyze in the middle bag, then concentrate the liquid in the dialysis bag, centrifuge, take ...

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Abstract

The invention discloses an application of polysaccharide of cistanche deserticola to preparation of functional foods with effects of assistance in inhibiting colon cancer. Polysaccharide of cistanche deserticola is preferably prepared by adopting a preparation method comprising the following steps: with cistanche deserticola as a raw material, extracting with boiling water, and performing deproteinization, dialysis and ethanol treatment. Polysaccharide of cistanche deserticola has a function of regulating a tumor microenvironment. Polysaccharide of cistanche deserticola provided by the invention is capable of regulating the tumor microenvironment through multiple approaches of inhibiting tumor angiogenesis, suppressing the immunity, resisting oxidation and inhibiting the colon cancer fibroblast growth, and the like so as to indicate that polysaccharide of cistanche deserticola has a good function of assistance in inhibiting the colon cancer.

Description

technical field [0001] The invention belongs to the technical field of polysaccharides, and in particular relates to the application of Cistanche deserticola polysaccharides in the preparation of functional foods with the effect of assisting in inhibiting colon cancer. Background technique [0002] The study of immune negative regulation provides a new strategy for tumor therapy. In the tumor microenvironment, there are a large number of negative regulatory cells, which interact and influence each other, accompanied by the co-evolution of tumor cells and the microenvironment. Due to the immunogenic changes and abnormal growth of tumor cells, fibroblasts are stimulated to release inflammatory factors, antigen-presenting cells transmit tumor antigen signals, and jointly recruit immune cells to infiltrate into the tumor, and the abnormal proliferation of tumor cells causes damage to adjacent cells. Compression, leading to ischemic necrosis and other tissue damage, produces a l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/09A23L1/29C08B37/00A23L33/00
CPCA23L29/30A23L33/10A23V2002/00A23V2200/308A23V2250/21A23V2250/51
Inventor 胡明华王培培马方励梁明
Owner INFINITUS (CHINA) CO LTD
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