A kind of nano-medicine for treating cow endometritis and preparation method thereof

An endometritis and nano-drug technology, applied to nano-drugs for the treatment of cow endometritis and preparation thereof, and the field of nano-drugs for the treatment of cow's endometritis, can solve the problem of easily producing drug-resistant antibiotic milk, human health Harm, affecting breeding efficiency and other issues, to achieve the effect of good hydrophilicity, less toxic and side effects, and high bioavailability

An endometritis and nano-drug technology, applied to nano-drugs for the treatment of cow endometritis and preparation thereof, and the field of nano-drugs for the treatment of cow's endometritis, can solve the problem of easily producing drug-resistant antibiotic milk, human health Harm, affecting breeding efficiency and other issues, to achieve the effect of good hydrophilicity, less toxic and side effects, and high bioavailability

CN104288222BInactive Publication Date: 2018-03-16XIANYANG VOCATIONAL TECHN COLLEGE
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  • A kind of nano-medicine for treating cow endometritis and preparation method thereof
  • A kind of nano-medicine for treating cow endometritis and preparation method thereof
  • A kind of nano-medicine for treating cow endometritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Under normal temperature and pressure, mix 6.5g oregano oil, 3.5g liquid paraffin, and 35g Tween-80, and stir evenly;

[0028] 2) Slowly add 45g of distilled water to the above mixture, and stir while adding. At the beginning, the viscosity of the system is small. With the addition of water, the system will become viscous. Continue to add dropwise and keep stirring until the oregano oil nano-emulsion colostrum is formed. ;

[0029] 3) Add 7.5 g of ethanol and 2.5 g of chlorhexidine acetate to the above-mentioned oregano oil nanoemulsion colostrum, stir evenly, and obtain.

[0030] After the present invention is diluted 5 to 10 times with distilled water, it can perfuse the uterus of dairy cows, effectively prevent and treat bacterial diseases of the reproductive system of dairy cows caused by Staphylococcus aureus, Escherichia coli, Streptococcus bacteria, etc., antibacterial and anti-inflammatory, and promote the recovery of uterine functions. Reduce infertility an...

Embodiment 2

[0032] 1) Under normal temperature and pressure, mix 10g oregano oil, 5g liquid paraffin, and 45g Tween-80, and stir evenly;

[0033] 2) Slowly add 22.5g of distilled water to the above mixture, and stir while adding. At the beginning, the viscosity of the system is small. With the addition of water, the system will become viscous. Continue to add dropwise and keep stirring until the oregano oil nanoemulsion primary is formed. milk;

[0034] 3) Add 15g of propylene glycol and 5g of chlorhexidine acetate to the above-mentioned oregano oil nanoemulsion colostrum, stir evenly, and obtain final product.

[0035] After the present invention is diluted 10-20 times with distilled water, it can perfuse the uterus of dairy cows, effectively prevent and treat bacterial diseases of the reproductive system of dairy cows caused by Staphylococcus aureus, Escherichia coli, Streptococcus bacteria, etc., antibacterial and anti-inflammatory, and promote the recovery of uterine functions. Reduc...

Embodiment 3

[0037] 1) Under normal temperature and pressure, mix 0.4g oregano oil, 0.2g liquid paraffin, 1.8g Tween-80, and stir evenly;

[0038] 2) Slowly add 96.9g of distilled water to the above mixture, and stir while adding. At the beginning, the viscosity of the system is small. With the addition of water, the system will become viscous. Continue to drop and stir until the oregano oil nanoemulsion is formed. milk;

[0039] 3) Add 0.6 g of ethanol and 0.1 g of chlorhexidine acetate to the above-mentioned oregano oil nanoemulsion colostrum, stir evenly, and obtain.

[0040] Directly perfusing the uterus of dairy cows with the present invention can effectively prevent bacterial diseases of the reproductive system of dairy cows caused by Staphylococcus aureus, E. .

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Abstract

The invention discloses a nano-medicine for treating dairy cow endometritis. The nano-medicine is prepared from the following components in percentage by mass: 0.4-10% of oregano oil, 0.2-5% of liquid paraffin, 1.8%-45% of surfactant, 0.6%-15% of cosurfactant, 0.1%-5% of chlorhexidine acetate and 20%-96.9% of distilled water. The nano-medicine is used for treating the dairy cow endometritis and administrated in such a manner of uterus perfusion, and is remarkable in curative effect, and capable of diminishing inflammation and sterilizing, contracting the uterus to drain pus and promoting the recovery of the functions of the dairy cow uterus. The nano-medicine for treating the dairy cow endometritis is antibiotic-free, residual-free, and safe and reliable.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a nano-medicine for treating cow endometritis, which can inhibit and kill the pathogenic bacteria of cow endometritis, promote the recovery of cow uterus function, has no resistance and no residue, is green, safe and efficient. Specifically relates to a nano-medicine for treating cow endometritis and a preparation method thereof. Background technique [0002] Cow endometritis is a postpartum reproductive disorder of dairy cows, and the incidence rate is very high in all countries in the world. According to reports, the incidence rate in my country is 20% to 50%, which seriously affects the breeding efficiency and causes huge economic losses. [0003] The pathogenic microorganisms that cause endometritis in cows are mainly Staphylococcus aureus, Escherichia coli, and Streptococcus. At present, antibiotics are generally used in veterinary clinics to treat them effectively, but the...

Claims

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Application Information

Patent Timeline
16 Mar 2018
Publication
CN104288222B
IPC
A61K36/53; A61K9/107; A61P15/00; A61P31/04; A61P15/08; A61K31/155
CPC
A61K9/0034; A61K9/1075; A61K31/155; A61K36/53; A61K2300/00
Inventors
张文娟; 王金虎