Micro hole blocking detection method, system, and blood cell analyzer

Abstract

The invention provides a micro hole blocking detection method, a micro hole blocking detection system and a blood cell analyzer. The system includes a micro hole voltage extraction circuit which is connected with positive and negative electrodes at two sides of a micro hole of medical equipment and is used for acquiring voltage signals between the positive and negative electrodes and recording a micro hole voltage curve formed by a plurality of voltage signals, and a micro hole voltage characteristic analysis module which is connected with the micro hole voltage extraction circuit and is used for performing characteristic analysis on the voltage signals on the micro hole voltage curve and identifying whether the voltage signals mutate, and detecting whether the micro hole is blocked or not based on a time point of mutation occurrence when the micro hole voltage characteristic analysis module identifies that the voltage signals mutate. With the micro hole blocking detection method, the micro hole blocking detection system and the blood cell analyzer provided by the embodiment of the invention adopted, whether the voltage signals mutate can be accurately judged, and therefore, whether the micro hole is blocked or not can be detected based a time point of mutation occurrence.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method and system for detecting micropore blockage of medical equipment, and a blood cell analyzer. Background technique [0002] Coulter's principle is commonly used in blood cell analyzers to count and group blood cells. In the counting cell of the analyzer there is a small opening called a microwell. like figure 1 As shown, there is a pair of positive and negative electrodes on both sides of the micropore, connected to a constant current power supply. Because cells are poor conductors of electricity, when the cells in the diluted sample pass through the detection micropore under the action of pressure, the resistance between the electrodes changes, thus forming a pulse signal proportional to the cell volume at both ends of the electrodes. The number of pulses is equivalent to the number of cells passing through the micropore, and the amplitude of the pulses is proportion...

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Problems solved by technology

However, the voltage at both ends of the micropore is greatly affected by factors such as the conductivity of the solution, temperature, liquid flow, and the physical parameters of the micropore itself. Using this method to determine whether the hole is blocked will have a very high misjudgment rate.

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