Antibiosis use of licochalcone A

A kind of licorice chalcone, the technology of use, is applied in the use field of licorice chalcone A in the preparation of antibacterial drugs or food

Inactive Publication Date: 2015-02-11
MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The anti-streptococcus effect of licochalcone A, especially against Streptococcus mutans and Streptococcus suis has not been reported

Method used

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  • Antibiosis use of licochalcone A
  • Antibiosis use of licochalcone A
  • Antibiosis use of licochalcone A

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0012] Example Antibacterial effect of licochalcone A

[0013] 1. Experimental materials

[0014] 1. Strains: Streptococcus mutans, purchased from ATCC, numbered ATCC55677; Streptococcus suis serotype 2 (Streptococcus suis serotype2) (PLoS ONE2(3): e315), purchased from China CDC Infectious Disease Prevention and Control Institute; Chinese isolate of group A streptococcus (GAS G519) (Journal of Clinical Microbiology, 2009, 47(3): 715-720), purchased from China CDC Infectious Disease Prevention and Control Institute.

[0015] 2. Experimental equipment

[0016] Licochalcone A: purchased from Sigma Company; THB medium: purchased from BD Company; yeast extract, peptone: purchased from OXOID Company. CO2 incubator: Japan Sanyo Company, biological safety cabinet: American Thermo Company.

[0017] 2. Experimental method

[0018] 1. Preparation of Liquid Medium

[0019] THB medium (30g THB per liter) or LB (10g sodium chloride, 5g yeast extract, 10g peptone per liter), autoclaved...

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Abstract

The invention discloses an antibiosis use of licochalcone A. Experiments prove that the licochalcone A can be used to prepare antibiosis medicines, food additives or cosmetics due to its antibiosis effect.

Description

technical field [0001] The present invention relates to an antibacterial use of licochalcone A, in particular to the use of licochalcone A in the preparation of antibacterial drugs or food. Background technique [0002] Chalcones are chemical components of Chinese herbal medicines, mainly found in medicinal plants such as licorice, safflower, and broad bean root, and are also a type of yellow pigment commonly used in modern industry. Chalcones have greater flexibility due to their structural characteristics, so they exhibit a wide range of pharmacological effects, mainly including anti-tumor, scavenging oxygen free radicals, antioxidant and antibacterial effects, etc., and their antibacterial effects are especially for Gram positive bacteria, and the effect of some compounds is comparable to that of gentamicin. [0003] Chalcone extracted from licorice root can be subdivided into the following new components: thorny chalcone, chalcone A, chalcone B, chalcone C and chalcone ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P31/04A23L1/30A61K8/35A23L33/105
CPCA61K31/12A23L3/3472A61K8/35
Inventor 姜永强郑玉玲郝淮杰王燕子郑新江华惠文佳
Owner MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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