Application of glycyrrhizinic acid in preparation of medicine used for preventing and treating ionizing radiation injury

Abstract

The invention relates to the field of medicines and discloses application of glycyrrhizinic acid in preparation of a medicine used for preventing and treating ionizing radiation injury. Glycyrrhizinic acid is also called glycyrrhizin and is a saponin ingredient separated from traditional Chinese medicine liquorice with English names of glycyrrhizin and glycyrrhizic acid and a molecular formula of C12H22O16 and molecular weight of 833.94 and CAS number of 1405-86-3. The invention discloses a radiation protective effect of glycyrrhizinic acid in cell level and living animal, glycyrrhizinic acid has the protective effect in a wide-dosage range including lethal dosage, sub-lethal dosage and low-dosage radiation, quality of glycyrrhizinic is stable, cost is low, source is wide, and glycyrrhizinic can be used for preparing a medicine used for preventing and treating related severe injuries and diseases which are caused by the ionic radiation.

Description

Involved areas The invention relates to the field of medicine, specifically a saponin component (can be artificially synthesized) extracted from plant licorice, molecular formula C 12 h 22 o 16 , molecular weight 833.94, CAS No. 1405-86-3, application of glycyrrhizic acid in the preparation of prevention and treatment of related damage and disease treatment caused by ionizing radiation. Background technique With the vigorous development of the global nuclear industry, nuclear technology has been widely used in various fields such as nuclear power plants, aerospace industry, national defense, and biomedicine. The hidden dangers of nuclear war and nuclear terrorism, the protection and treatment of body damage caused by ionizing radiation (referred to as radiation damage) are receiving more and more attention. On the other hand, the incidence of malignant tumors and the number of patients have been on the rise in recent years. Radiation therapy, as one of the main treatmen...

AI Technical Summary

Problems solved by technology

Drugs related to the treatment of radiation damage currently on the market mainly include: sulfur-containing compounds, hormones, cytokines, and Chinese herbal medicines, etc., which have their own inherent defects: for example, sulfur-containing compounds generally have relatively large side effects, and amifostine (also known as amifostine ) as the representative of this type of compound is currently recognized as the compound with the best protective effect, and is the first selective broad-spectrum cytoprotective agent passed by the international regulatory agency, but the half-life is extremely short (7 minutes) and expensive (domestic The medical market price is 400-500 yuan / branch) which limits its application; while the prevention and treatment of hormonal drugs to radiation damage is mainly to bone marrow nucleated cells, hematopoietic stem cells and progenitor cells, and the impact of such drugs on sexual organs and reproductive system It limits its wide use; cytokine drugs such as interleukins and colony-stimulating factor drugs can alleviate and treat the damage to the bone marrow hematopoietic function system caused by radiation, but its radiation protection effect is closely related to the time of administration (used for prevention and In the medical practice of rescue and treatment, such drugs require high levels of medical testing and attention), have obvious inflammatory effects, are expensive, and are difficult to store at room temperature; anti-radiation components of Chinese herbal medicines mainly include phenols, polysaccharides, natural Flavonoids have the characteristics of unclear active ingredients and low toxicity. After years of research, there are no similar drugs on the market or to be listed

The compound has been widely reported to have anti-tumor, treatment of cardiovascular and cerebrovascular ischemia-reperfusion injury, neurodegenerative diseases, inflammatory diseases and other fields, but so far, glycyrrhizic acid has been used in the preparation of prevention and treatment of ionizing radiation injury treatment and tumor radiation. The use of therapeutic adjuvant drugs has not been reported

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