34 results about "Radiation-Protective Effects" patented technology

Methods of mitigating the effects of radiation exposure or providing a radioprotective effect in a subject are provided herein. The methods include administering a therapeutically effective amount of cerium oxide nanoparticles to the subject to mitigate the effects of radiation exposure or to offer a radioprotective effect to the subject. The cerium oxide nanoparticles are suitably less than 20 nm in diameter and have over 50% of the cerium in the 3+ oxidation state.

The invention provides a new compound with a radiation protection function, and pharmaceutically acceptable salt, pro-drug and solvate. The compound and the pharmaceutically acceptable salt, pro-drug and solvate are as shown in formula (I): a chemical formula is shown in the original PDF, wherein W is selected from carbonyl, sulfoxide and sulfonyl; R<1> is selected from substituted or un-substituted aromatic ring or aromatic heterocycle: chemical formulae are shown in the original PDF; X is selected from carbon and nitrogen; R<4> is selected from hydrogen, halogen, cyan, substituted or un-substituted C1-3 alkyl or alkoxy, methyl, trifluoromethyl, methoxyl, and trifluoromethoxy; R<2> is selected from the following perssad: chemical formulae are shown in the original PDF; R<3> is selected from hydrogen, methyl, vinyl and the like; when the W is selected from the sulfonyl, and the R<1> is selected from 4-fluorophenyl, 4-chlorophenyl, 4-iodophenyl and 4-trifluoromethoxy phenyl, the R<2> cannot be selected from 4-carboxyphenyl and 4-carboxyphenyl sodium, and the R<3> cannot be selected from the hydrogen; and when the W is selected from the sulfoxide and the R<1> is selected from 4-fluorophenyl, 4-chlorophenyl, and 4-iodophenyl, the R<2> cannot be selected from 4-carboxyphenyl and 4-carboxyphenyl sodium, and the R<3> cannot be selected from the hydrogen.

The present disclosure relates to methods for preventing or treating a radiation-induced disease, disorder, or condition by administering apilimod to a subject in need thereof, and related compositions.