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A compound traditional Chinese medicine for radiation protection

A technology of radiation protection and compound Chinese medicine, which is applied in the direction of drug combination, drug delivery, and medical formula, which can solve the problems of staying and the few reports of traditional Chinese medicine compound radiation protection drugs, and achieve the effect of convenient use, low price and wide distribution of drugs

Active Publication Date: 2016-03-30
NAVY MEDICINE RES INST OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on anti-radiation of traditional Chinese medicine mainly stays at the level of single-flavored qi-tonifying and blood-tonifying medicines, but there are not many reports on the use of traditional Chinese medicine compound prescriptions for radiation protection medicines

Method used

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  • A compound traditional Chinese medicine for radiation protection
  • A compound traditional Chinese medicine for radiation protection
  • A compound traditional Chinese medicine for radiation protection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The prescription optimization experiment of embodiment 1 Chinese medicine compound prescription

[0028] Hematopoietic tissue is very sensitive to ionizing radiation, and the radiation damage of the hematopoietic system and the resulting hematopoietic dysfunction are the key pathogenic links in the pathological changes of acute radiation sickness. Therefore, protecting hematopoietic tissue from radiation damage or reducing the degree of damage has always been one of the important research directions in the field of radiation damage prevention. After hematopoietic cells were damaged by radiation, the number of leukocytes reflected in the peripheral blood routine decreased sharply [Fan Ting, Lin Xinying, Zhao Yan, et al. Auxiliary protective effect of allicin on radiation injury in mice [J]. Environmental and Health Journal, 2004 , 24(9):718-720]. Therefore, in this experiment, the peripheral blood picture was selected as the pharmacodynamic index for prescription optimi...

Embodiment 230

[0061] Example 230 Day Survival Experiment

[0062] Methods: 100 healthy and clean Kunming mice, 22±2g, half male and half male, were randomly divided into model group, low, medium and high dose administration group and control group (female and male were kept in separate cages). In addition to the control group, the 60 Coγ source, single irradiation, dose rate 2.0Gy / min, absorbed dose 8.0Gy. According to the designed dose, the drug administration group was administered once a day for 7 days before and 7 days after the irradiation (recipe 5, the same below), and the dosage was 165 mg / kg body weight; the model group and the control group were given the same amount of normal saline . The survival of the mice was recorded, and the 30-day survival rate was determined.

[0063] Result: if figure 1 . 30 days after irradiation, all the model groups died, and the survival rate was 0, while the 30-day survival rates of the low, medium and high dose administration groups were 50%, ...

Embodiment 3

[0064] Embodiment 3 acute toxicity test

[0065] Methods: 60 healthy and clean Kunming mice, 22±2g, half male and half male, were randomly divided into low, medium and high dose administration groups (female and male were housed in separate cages). The drug dosage was prepared 30 times of the dosage in the 30-day survival test, administered once, and fed for 15 days routinely. The survival of the mice was recorded, and the mortality rate was determined.

[0066] Results: As shown in Table 4, the clinical dosage of the drug of the present invention is 3g / day, and the maximum tolerated oral dose for mice is 30.0g / kg body weight, which is equivalent to 465.2 times of the adult clinical dosage. Prompt, medicine of the present invention has no obvious acute toxicity.

[0067] Table 4 Acute toxicity test in mice

[0068]

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Abstract

The invention relates to the technical field of a traditional Chinese medicine, particularly relates to a compound traditional Chinese medicine for radiation protection, and discloses a compound traditional Chinese medicine for radiation protection. The compound traditional Chinese medicine is characterized by being prepared from the following components in parts by weight: 21-62 parts of astragalus membranaceus, 1-8 parts of grape pip, 16-46 parts of acanthopanax, 7-29 parts of rhizoma dioscoreae and 1-7 parts of spina date seed. Compared with the existing other medicines for radiation protection and treatment, the compound traditional Chinese medicine disclosed by the invention has the significant advantages and effects that 1, the medicine is convenient to use; 2, the medicine has a radiation protection effect and also has an auxiliary radiation injury treatment effect; 3, the medicine is refined from folk common herbs, and is good in pharmaceutical effect and free of toxic and side effects; 4, the used raw materials are common Chinese herbal medicines in China, and the compound traditional Chinese medicine is wide in distribution, and low in price, and is one of the advantages in future development and application.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a compound traditional Chinese medicine for radiation protection and its preparation method and application. Background technique [0002] With the development of science and technology, ionizing radiation has penetrated into many areas of human production and life, which will inevitably cause radiation damage to people, such as clinical radiotherapy for malignant tumor patients, radiation damage to occupationally exposed personnel and space radiation exposure to personnel during spaceflight. [0003] Radiation protectors (radioprotectors) refer to before and after the body or a certain biological system is exposed to ionizing radiation, early administration of certain substances can reduce its radiation damage and promote its recovery. Compounds (or drugs) that have this effect are called radioprotectors. . The main modern radioprotectants are: lipoic aci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/87A61K9/48A61K9/127A61K9/16A61K9/20A61K9/14A61K9/08A61P17/16A61P7/00
Inventor 唐瑛张建刘李娜周茜孙欢谷爱梅
Owner NAVY MEDICINE RES INST OF PLA
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