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Ionization radiation injury protective agent

A technology of ionizing radiation and protective agent, applied in the direction of ginkgo biloba medical raw materials, plant raw materials, skin diseases, etc., can solve the problems of hematopoietic function damage, low immunity, sulfur-containing protective agent, etc., and achieve the convenience of drug use and low cost. Inexpensive, easy to prepare effect

Inactive Publication Date: 2015-04-08
STATE GRID CORP OF CHINA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a protective agent for ionizing radiation damage without side effects, safe and convenient, and low in price, which overcomes related defects such as sulfur-containing and relatively high toxicity of the protective agent in the prior art, and effectively solves the problem of low immunity caused by long-term exposure to radiation, Hematopoietic damage and other issues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] An ionizing radiation damage protection agent is characterized in that it is prepared from the following weight ratio raw materials,

[0022] 30 parts of golden silk rattan, 30 parts of Houttuynia cordata, 30 parts of Polygonatum odoratum, 28 parts of medlar, 28 parts of Cortex Phellodendri,

[0023] 28 parts of ginkgo leaves, 28 parts of perilla leaves, 25 parts of duckweed, 25 parts of loquat leaves, 25 parts of Ligustrum lucidum,

[0024] 20 parts of turmeric, 20 parts of myrrh, 20 parts of frankincense, 20 parts of cassia seed, 18 parts of honeysuckle,

[0025] 18 parts of Salvia miltiorrhiza, 18 parts of purslane, 15 parts of mother-in-law needle, 15 parts of coix seed, 15 parts of Hedyotis diffusa,

[0026] 10 parts of licorice, 10 parts of schisandra, 10 parts of hawthorn, 7 parts of saponins, 5 parts of nepeta,

[0027] Prepared by the following method:

[0028] Take 30 parts of Houttuynia cordata, 30 parts of Polygonatum odoratum, 28 parts of medlar, 28 part...

Embodiment 2

[0034] Hematopoietic tissue is very sensitive to ionizing radiation, and the radiation damage of the hematopoietic system and the resulting hematopoietic dysfunction are the key pathogenic links in the pathological changes of acute radiation sickness. Therefore, protecting hematopoietic tissue from radiation damage or reducing the degree of damage has always been one of the important research directions in the field of radiation damage prevention. After the hematopoietic cells are damaged by radiation, the number of leukocytes reflected in the peripheral blood routine drops sharply. Therefore, the peripheral blood image is selected as the function verification index in this experiment.

[0035] experimental method

[0036] Select healthy SPF-grade Kunming mice, 60 males, and randomly divide them into 3 groups according to body weight, 20 in each group, namely: normal group, irradiation control group, and the preparation group of Example 1. Continuous administration for 14 day...

Embodiment 3

[0050] Effects of Nucleated Cells in Bone Marrow of Irradiated Mice and Spleen Weight and Spleen Index in Mice

[0051] The spleen is the largest lymphoid organ and one of the important peripheral immune organs, containing a large number of T cells, natural killer cells and killer cells activated by lymphokines. The spleen is also a place for immune response to blood-borne antigens, and it can synthesize and secrete biologically active substances such as complement and IFN. Spleen weight and spleen index indirectly reflect the immune status of the body.

[0052]SPF grade Kunming mice, 6-8 weeks old, male, weighing 18-22g, 60 mice.

[0053] Animal groups and methods

[0054] The experiment was divided into a normal group, an irradiation control group, and a drug group according to Example 1 of the present invention, with 20 rats in each group. One-time whole body irradiation with 60Co γ-rays, the dose rate is 3.2 seconds / cGy, the irradiation field is 25cm×25cm, the source-ski...

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PUM

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Abstract

The invention relates to an ionization radiation injury protective agent. The ionization radiation injury protective agent is prepared from the following raw materials: jasminum cinnamomifolium, houttuynia cordata, polygonatum odoratum, fructus lycii, cortex phellodendri, ginkgo leaves, perilla leaves, duckweed, loquat leaves, glossy privet fruits, curcuma aromatica and the like. The ionization radiation injury protective agent is convenient to use, has a radiation protection effect and also has an auxiliary radiation injury treatment effect, the adopted raw materials are traditional Chinese medicinal materials common in China and are widely distributed, the cost is low, and low cost is one of the advantages of the ionization radiation injury protective agent in future development and application, so that the ionization radiation injury protective agent has broad application prospects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine health-care medicine, and in particular relates to a protective agent for ionizing radiation damage containing traditional Chinese medicine components. Background technique [0002] With the development of science and technology, ionizing radiation has penetrated into many fields of human production and life, and it will inevitably cause radiation damage to people, such as radiation damage to occupational exposure personnel and space radiation to personnel in spaceflight, etc. Due to the nature of their work, workers in the power system face more radiation in different degrees, and science shows that these ionizing radiations all affect the health of the workers, which can induce cancer and accelerate the proliferation of cancer cells in the human body. Electromagnetic radiation pollution will affect the circulatory system, immunity, reproduction and metabolic functions of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P17/16
CPCA61K36/63A61K36/16A61K36/185A61K36/28A61K36/324A61K36/328A61K36/355A61K36/482A61K36/483A61K36/484A61K36/535A61K36/537A61K36/538A61K36/57A61K36/638A61K36/73A61K36/734A61K36/748A61K36/756A61K36/78A61K36/79A61K36/815A61K36/88A61K36/8969A61K36/8994A61K36/9066A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 魏若琳刘幸幸梁志超刘学昊常俊军曲若纹王彬彬孙瀚之李娜
Owner STATE GRID CORP OF CHINA
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