Medical hydrogel with radiation prevention effect

A hydrogel and medical technology, applied in the field of biomedicine, can solve the problems of wide molecular weight distribution, low long-term stability and unfavorable discharge of hyperbranched polymers

Active Publication Date: 2019-04-19
SHANGHAI RUINING BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The aldehyde groups in the aldehyde group-terminated hyperbranched polymer HP-PEG-CHO are linked to the polymer through ester bonds, and the long-term stability in aqueous solution is low. In addition, the molecular weight distribution of the hyperbranched polymer is wide and may contain higher molecular weight Polymers that are not conducive to human excretion

Method used

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  • Medical hydrogel with radiation prevention effect
  • Medical hydrogel with radiation prevention effect
  • Medical hydrogel with radiation prevention effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 The long-term gelation stability of ether bond, amide bond and ester bond-linked benzaldehyde group-terminated polyethylene glycol in aqueous solution 600mg of ester bond-connected benzaldehyde group-terminated 8-arm polyethylene glycol 8-PEG-amide-BA, amide bond connected to benzaldehyde group-terminated 8-arm polyethylene glycol 8-PEG-amide-BA and ether bond connected to benzaldehyde group-terminated 8-arm polyethylene glycol 8-PEG-O- BA was dissolved in 2 mL of 0.1M phosphate buffer solution (pH 7.4) as A solution; the configuration contained polylysine 2.75% (w / v) (the ratio of amino group to aldehyde group was 1:1) and polyethyleneimine (MW1.8K) 0.67% (w / v) (amino group to aldehyde group ratio is 0.4:1) phosphate buffer solution, as the B solution; mix the A and B solutions in equal volumes to obtain a viscous hydrogel , Record the initial gel time. Place the three A liquids in a constant temperature incubator at 60 degrees Celsius. After two months (equi...

Embodiment 2

[0042] Example 2 Gelling time and stability of hydrogels of different formulations in aqueous solutions

[0043] Dissolve 600 mg of amide bond-linked benzaldehyde group-terminated 8-arm polyethylene glycol 8-PEG-amide-BA (MW13.5K) in 2 mL of phosphate buffer (pH 7.4) as solution A; configuration is different The content of polylysine and polyethyleneimine (MW1.8K) in a phosphate buffer solution is used as the B solution; the A and B solutions are mixed in equal volumes to obtain a viscous hydrogel. In the following table, the amount ratio of polyethyleneimine and polylysine is represented by the molar ratio of the aldehyde groups in the star-shaped multi-arm polyethylene glycol terminated by their respective amino groups and aldehyde groups.

[0044]

[0045]

[0046] The results show that the content of polylysine significantly affects the stability of the hydrogel in aqueous solution. When the molar ratio of the amino group of polylysine to the aldehyde group of 8-PEG-amide-BA is...

Embodiment 3

[0048] Dissolve 400 mg of amide bond-linked benzene aldehyde group-terminated 8-arm polyethylene glycol 8-PEG-amide-BA (MW10K) in 2 mL of phosphate buffer (pH 7.4) as solution A; configure polylysine Acidic 2.44% (w / v) borate buffer solution (amino group to aldehyde group ratio 1:1), as B solution; mix A and B solutions in equal volumes to obtain a viscous hydrogel, gel time It is 25 seconds, and the in vitro stability exceeds 1 month.

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Abstract

The invention discloses medical hydrogel. The medical hydrogel is formed by in-situ crosslinking of formyl-terminated star-shaped multi-arm polyethylene glycol and a poly-amino compound. Formyl groupsare connected with star-shaped multi-arm polyethylene glycol through chemical bonds such as an ether bond, an amide bond, an urethane bond and an imine bond or a urea bond, wherein the molar ratio ofamino groups in the poly-amino compound to the formyl groups in formyl-terminated star-shaped multi-arm polyethylene glycol is (0.4-4.4):1. The poly-amino compound is polylysine or a mixture of polylysine and polyethyleneimine, and the molar ratio of polylysine to polyethyleneimine is (2-30):3. The hydrogel is high in gel formation speed, has long-term stability in an aqueous solution, still maintains good swelling performance and high stability after being subjected to irradiation several time, and can be used as a medical radiotherapy protection pad for radiation protection.

Description

Technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a medical hydrogel, which can be used as a radiation protection material for radiotherapy gaskets, postoperative tissue sealing and anti-leakage, anti-tissue adhesion, tissue filler, tissue repair, skin Dressings and drug release areas. Background technique [0002] Hydrogel is a soft material that is cross-linked by hydrophilic polymer and contains a lot of water. Hydrogel has excellent physical and chemical properties and biological properties, such as high water content, high elasticity, softness, and biocompatibility. It has important application value in biomedical research fields such as drug delivery and tissue engineering. Injectable hydrogel refers to a type of hydrogel with certain fluidity that can be applied by injection. It shows a phase transition between sol and gel to external stimuli (changes in temperature, temperature / pH, etc.). It is liquid or semi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14
CPCA61L31/06A61L31/14A61L31/145A61L2400/06C08L71/02A61N2005/1094A61N5/10A61B90/04A61B2090/0815A61B2090/0816A61B2090/0481A61L27/52A61L27/50A61L27/18C08J3/075C08J3/246C08J2371/02C08J2377/04C08J2300/206C08J2379/02C08L77/04C08J3/243
Inventor 潘震陈亮侯森
Owner SHANGHAI RUINING BIOTECH CO LTD
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