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Application of shrubby sophora extract in treatment of HPV

A technology of extract and Sophora flavescens, applied in the field of medicine, can solve the problems of no curative effect, affirmative HPV virus drugs, etc., and achieve the effect of exact curative effect

Inactive Publication Date: 2015-04-22
GUIYANG XINTIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, no effective anti-HPV drugs have been found, only conventional antiviral drugs such as imiquimod, and recombinant human interferon preparations, such as Andafen Suppositories, Shurun ​​Suppositories, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 10 g of Sophora flavescens powder, and extract matrine by ethanol reflux method, including the following steps:

[0020] (1) Take Sophora flavescens as raw material, take the volume percentage concentration as 60% ethanol reflux extraction to obtain reflux liquid, and the material-to-liquid ratio is 12; adopt the ethanol reflux method to extract 2 times, recover ethanol by vacuum distillation and obtain the extraction extract ;

[0021] (2) adding 1% by weight of cellulase and 1% sodium sulfite to the extract, and incubating at 37±1°C for 12-24 hours;

[0022] (3) adjusting the pH of the filtrate to between 3 and 4 with HCl, filtering the filtrate, adjusting the pH to between 10 and 11 with NaOH, and then concentrating the filtrate;

[0023] (4) Extract the concentrated filtrate with ethanol, combine the ethanol layers, and evaporate to dryness under reduced pressure to obtain the matrine extract.

Embodiment 2

[0025] Take 10 g of Sophora flavescens powder, and extract matrine by ethanol reflux method, including the following steps:

[0026] (1) Take Sophora flavescens as raw material, take the volume percentage concentration as 60% ethanol reflux extraction to obtain reflux liquid, and the material-to-liquid ratio is 12; adopt the ethanol reflux method to extract 2 times, recover ethanol by vacuum distillation and obtain the extraction extract ;

[0027] (2) adding 1% by weight of cellulase and 1% sodium sulfite to the extract, and incubating at 37±1°C for 12-24 hours;

[0028] (3) adjusting the pH of the filtrate to 3-4 with HCl, filtering the filtrate, adjusting the pH to 10-11 with NaOH, and then concentrating the filtrate;

[0029] (4) Extract the concentrated filtrate with ethanol, combine the ethanol layers, and evaporate to dryness under reduced pressure to obtain the matrine extract.

[0030] (5) According to the weight ratio of vitamin E and matrine extract is 10:250, vit...

Embodiment 3

[0032] Take 10 g of Sophora flavescens powder, and extract matrine by ethanol reflux method, including the following steps:

[0033] (1) Take Sophora flavescens as raw material, take the volume percentage concentration as 60% ethanol reflux extraction to obtain reflux liquid, and the material-to-liquid ratio is 12; adopt the ethanol reflux method to extract 2 times, recover ethanol by vacuum distillation and obtain the extraction extract ;

[0034] (2) adding 1% by weight of cellulase and 1% sodium sulfite to the extract, and incubating at 37±1°C for 12-24 hours;

[0035] (3) adjusting the pH of the filtrate to 3-4 with HCl, filtering the filtrate, adjusting the pH to 10-11 with NaOH, and then concentrating the filtrate;

[0036] (4) Extract the concentrated filtrate with ethanol, combine the ethanol layers, and evaporate to dryness under reduced pressure to obtain the matrine extract.

[0037] (5) According to the weight ratio of vitamin E and matrine extract is 10:350, vit...

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PUM

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Abstract

The invention discloses an application of a shrubby sophora extract in treatment of HPV. The method comprises the following steps: extracting total matrines by virtue of an ethanol refluxing process, treating the extracting solution by adopting cellulase and sodium sulfite, thereby obtaining the shrubby sophora extract. According to clinical research, the shrubby sophora extract for treating the HPV in the invention has exact and obvious curative effect on cervical HPV infection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of Sophora flavescens extract in the treatment of HPV. Background technique [0002] Cervical cancer is the second most common cancer in women and one of the most common malignant tumors in the world. The incidence and mortality of cervical cancer in my country account for about 1 / 3 of the world's, and the mortality rate in Gansu is as high as 39 / 100,000. Studies have confirmed that human papillomavirus (HPV) infection is the main risk factor for cervical cancer. From HPV infection to the appearance of cervical precancerous lesions, and then to cervical cancer, this is a relatively long process, which generally takes 3-8 years. time of year. At present, there is no unified plan for the treatment of cervical HPV infection in clinical practice. Cervical cancer is expected to become a preventable and curable disease if it can be diagnosed, prevented and treated e...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61P31/20A61P15/00
Inventor 张杰杨素娜
Owner GUIYANG XINTIAN PHARMA CO LTD
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