Application of Sophora flavescens extract in the treatment of hpv

A technology of extract and Sophora flavescens, which is applied in the field of medicine, can solve the problems of not finding drugs with curative effect and affirming HPV virus, etc., and achieve the effect of exact curative effect.

Active Publication Date: 2018-04-27
GUIYANG XINTIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, no effective anti-HPV drugs have been found, only conventional antiviral drugs such as imiquimod, and recombinant human interferon preparations, such as Andafen Suppositories, Shurun ​​Suppositories, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 10 g of Sophora flavescens powder, extract according to the arrangement of orthogonal experiments in Table 1, and use the Sophora flavescens yield as an index to measure the extraction results.

[0019] Adopt ethanol reflux method to extract matrine, comprising the following steps:

[0020] (1) Using Sophora flavescens as raw material, reflux extraction with 60% ethanol by volume percentage concentration to obtain reflux liquid, the ratio of solid to liquid is 1:12; use the ethanol reflux method to extract twice, and recover ethanol by distillation under reduced pressure and obtain the extracted extract;

[0021] (2) Add 1% by weight cellulase and 1% sodium sulfite to the extract, incubate at 37±1°C for 12-24 hours, and then filter to obtain the filtrate;

[0022] (3) After adjusting the pH of the filtrate to between 3 and 4 with HCl, filter the filtrate, and adjust the pH to between 10 and 11 with NaOH, and then concentrate the filtrate;

[0023] (4) Extract the...

Embodiment 2

[0024] Embodiment 2: pharmacodynamic experiment

[0025] 1. Case data Patients who were positive for cervical HPV infection in the obstetrics and gynecology clinic of a hospital in Lanzhou from December 2012 to December 2013 were randomly divided into 3 groups according to the admission number, 120 cases in the treatment group and 120 cases in the positive control group. The negative control group excluded some patients who were not suitable for other factors, totaling 120 cases.

[0026] 2 Inclusion criteria (1) Sexual life history or married non-pregnant women, aged 18-45 years; (2) HPV-DNA infection positive; (3) Cervical intraepithelial neoplasia (CIN) grade I; (4) No major organ disease; (5) No history of drug allergy (especially those with allergic constitution); (6) The patient gave informed consent to accept this test. The exclusion criteria were: acute reproductive tract inflammation (gonorrhea, mycoplasma or chlamydia infection); those who interrupted the treatment ...

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PUM

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Abstract

The invention discloses the application of Sophora flavescens extract in treating HPV. The total alkaloids of Sophora flavescens are extracted by an ethanol reflux method, and the extract is treated with cellulase and sodium sulfite to obtain the Sophora flavescens extract. The sophora flavescens extract for treating HPV of the present invention has definite and obvious curative effect on treating cervical HPV infection through clinical research.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of Sophora flavescens extract in treating HPV. Background technique [0002] The incidence of cervical cancer ranks second among female tumors, and it is one of the most common malignant tumors in the world. The morbidity and mortality of cervical cancer in my country account for about 1 / 3 of the world, while the mortality rate in Gansu is as high as 39 / 100,000. Studies have confirmed that human papillomavirus (HPV) infection is the main risk factor for cervical cancer. It is a relatively long process from HPV infection to cervical precancerous lesions and then to cervical cancer, which generally takes 3 to 8 months. time of year. At present, there is no unified protocol for the treatment of cervical HPV infection clinically. If it can be diagnosed, prevented and treated early, cervical cancer will hopefully become a disease that can be prevented and cured. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/489A61K9/06A61P31/20A61P35/00
CPCA61K36/489A61K2236/331A61K2236/51
Inventor 张杰刘东泽
Owner GUIYANG XINTIAN PHARMA CO LTD
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