Medicine composition treating obesity and application of medicine composition

A technology of obesity and composition, applied in the field of medicine, can solve the problem of immunoglobulin G that has not been reported

Active Publication Date: 2015-04-22
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report about the application of immunoglobulin G in the preparation of drugs for the treatment and prevention of obesity

Method used

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  • Medicine composition treating obesity and application of medicine composition
  • Medicine composition treating obesity and application of medicine composition
  • Medicine composition treating obesity and application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Immunoglobulin G reduces body weight and fat experiment under food restriction condition

[0033] 1. Experimental materials

[0034] Clean-grade C56 mice were purchased from Shanghai Slack Laboratory Animals Co., Ltd.; immunoglobulin G was from two companies, Shanghai Abmart (liquid) and American Sigma (powder); albumin was purchased from American Sigma ; Immunoglobulin G1-Fc segment protein was purchased from Beijing Yiqiao Shenzhou Biotechnology Co., Ltd.

[0035] 2. Experimental method

[0036] Before the experiment, 36 C56 mice were fed with basal feed for 1 month in the experimental environment, and after adapting to the environment, they were randomly divided into six groups, with 6 mice in each group, as follows:

[0037] a) abmart solvent control group;

[0038] b) abmart immunoglobulin G;

[0039] c) sigma immunoglobulin G;

[0040] d) sigma albumin;

[0041] e) immunoglobulin G1-Fc segment protein;

[0042] f) Control group.

[0043] The body...

Embodiment 2

[0052] Example 2 Experiment of Immunoglobulin G Reducing Body Weight and Fat in Obese Mice under Food Restriction Conditions

[0053] 1. Experimental materials

[0054] Clean grade C56 mice were purchased from Shanghai Slack Experimental Animals Co., Ltd.; immunoglobulin G was purchased from Sigma, USA.

[0055] 2. Experimental method

[0056] Before the experiment, 10 C56 mice were fed with basal feed for one month in the experimental environment, and were randomly divided into two groups after adapting to the environment, with 5 mice in each group. The groups were as follows:

[0057] a) High fat+restricted food group;

[0058] b) High fat + food restriction + Sigma immunoglobulin G group.

[0059] All mice were first given high-fat diet (Research Diets company, product number D12492) free to eat for three months, and then restricted food for three weeks according to 75% food intake; a) group was given injection of a solvent for dissolving immunoglobulin, and the solvent ...

Embodiment 3

[0068] Example 3 Drugs that can simulate food restriction combined with immunoglobulin G to reduce body weight and fat

[0069] 1. Experimental materials

[0070] Clean grade C56 mice were purchased from Shanghai Slack Experimental Animals Co., Ltd.; immunoglobulin G was purchased from Sigma Corporation of the United States; metformin was purchased from Sigma Corporation of the United States; resveratrol was purchased from Sigma Corporation of the United States.

[0071] 2. Experimental method

[0072] Before the experiment, 12 C56 mice were fed with basal feed for 1 month in the experimental environment. After adapting to the environment, they were randomly divided into 3 groups with 4 mice in each group. The groups were as follows:

[0073] a) metformin + immunoglobulin G group;

[0074] b) Metformin group;

[0075] c) Resveratrol + immunoglobulin G group

[0076] d) resveratrol group;

[0077] e) Control group.

[0078] All mice were free to eat high-fat diet (Researc...

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PUM

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Abstract

The invention discloses a medicine composition treating obesity and an application of the medicine composition and relates to immune globulin G and the application of the combined usage of the immune globulin G and a medicine capable of simulating food limiting in treating and/or preventing the obesity. By means of the weight and fat losing experiment through the immune globulin G under the food limiting condition, it is proved that the immune globulin G can promote the reduction of the weight and the fat content of normal mice and high-fat induction obesity mice. By means of the experiment of combining the medicine capable of simulating the food limiting and the immune globulin G to reduce the weight and fat, it is proved that the combination of the immune globulin G and the medicine capable of simulating the food limiting can promote the reduction of the weight and the fat content of the mice. A new application is provided for the immune globulin G, and a more effective treatment medicine is provided for treating the obesity.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating obesity and its application. Background technique [0002] Obesity is a common group of metabolic disorders. When the human body eats more calories than it consumes, the excess calories are stored in the body in the form of fat, and its content exceeds the normal physiological needs, and when it reaches a certain value, it becomes obesity. Normal adult adipose tissue accounts for 15% to 18% of body weight in males and 20% to 25% in females. Obesity is a complex multifactorial disease formed by the interaction of genetic, metabolic, social, behavioral, cultural and other factors. According to the causes of obesity, it can be divided into hereditary obesity, secondary obesity, and simple obesity, and the vast majority of obese patients are simple obesity. After entering the 21st century, the material level has been greatly improved, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K45/00A61P3/04A61K31/155A61K31/05A61K38/26
Inventor 缪朝玉李志勇管云枫
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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