External lotion for treating vulva lichen sclerosus

A technology for sclerosis and lichen, which is applied to medical preparations containing active ingredients, diseases, plant/algae/fungus/moss components, etc., and can solve problems such as no therapeutic drugs found and unclear pathogenesis

Inactive Publication Date: 2015-05-13
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, its pathogenesis is still unclear, and n...

Method used

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  • External lotion for treating vulva lichen sclerosus
  • External lotion for treating vulva lichen sclerosus
  • External lotion for treating vulva lichen sclerosus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 20g of Cnidium monnieri, 10g of Sophora flavescens, 10g of Kochia scoparia, 10g of Ligusticum chuanxiong, 10g of white fresh peel, 15g of cinnamon sticks, 10g of psoralen, 10g of forsythia, 10g of wild chrysanthemum, 10g of cork, 10g of Cyperus radiata, 10g of red peony 15g of comfrey, add 8 times and 8 times the amount of water to extract twice for 2 hours each time, combine the filtrate and concentrate to 1.05-1.10.

Embodiment 2

[0017] Take 30g of Cnidium monnieri, 20g of Sophora flavescens, 20g of Kochia scoparia, 20g of Ligusticum chuanxiong, 20g of white fresh peel, 20g of cinnamon sticks, 20g of psoralen, 15g of forsythia, 20g of wild chrysanthemum, 15g of cork, 18g of Cyperus rotundus, 20g of red peony 30g of comfrey, add 8 times and 8 times the amount of water to extract twice for 2 hours each time, combine the filtrate and concentrate to 1.05-1.10.

Embodiment 3

[0020] clinical information

[0021] The cases were from patients who were treated at the Gynecology Clinic of Traditional Chinese and Western Medicine of Qilu Hospital of Shandong University from June 2006 to June 2014. All patients were excluded from other vulvar and cervical diseases, and systemic diseases such as tumors, diabetes, autoimmune diseases, etc., and each case was finally confirmed by pathology by biopsy before being included in the group. Patients meeting the criteria were randomly divided into 2 groups, one group was the invention group, and the other was the western medicine group, with 58 cases respectively.

[0022] The course of the 116 patients ranged from 0.5 to 20 years, and the age ranged from 21 to 82 years. The average age was 51.63±10.36 years. There were 96 cases of vaginal pruritus, 92 cases of vaginal skin mucosa became lighter, and 21 cases had local ulcers. There was no significant difference in general conditions between the two groups.

[0023] D...

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Abstract

The invention provides external lotion for treating vulva lichen sclerosus. The external lotion is prepared from the following raw materials in parts by weight: 20-30 parts of fructus cnidii, 10-20 parts of radix sophorae flavescentis, 10-20 parts of fructus kochiae, 10-20 parts of ligusticum wallichii, 10-20 parts of cortex dictamni, 15-20 parts of cassia twig, 10-20 parts of fructus psoraleae, 10-15 parts of fructus forsythiae, 10-20 parts of mother chrysanthemum, 10-15 parts of golden cypress, 10-18 parts of rhizoma cyperi, 10-20 parts of root of common peony and 15-30 parts of lithospermum. The pruritus vulvae symptoms of patients can be relieved, so that the color of the vulva can be restored to be normal, and the lesion range is narrowed.

Description

Technical field [0001] The invention relates to a medicine for treating lichen sclerosus of the vulva, in particular to an external lotion for treating lichen sclerosus of the vulva prepared from Chinese herbal medicine. Background technique [0002] Lichen sclerosus of the vulva, as a common and refractory disease in gynecology and dermatology clinics, is a group of chronic inflammatory diseases, manifested by degeneration of the skin and mucous membrane of the vulva, as well as local pigment changes. The most common symptom of this disease is intractable genital itching, which is obvious when falling asleep, often because it is unbearable and affects sleep. In some patients, the condition progressed, the clitoris and vaginal opening were atrophy and then adhesions, causing poor urination, dyspareunia, scratching due to intense itching, and local skin cracks and ulcers, which seriously affected the quality of life of the patients. The main pathological features of this disea...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P15/00A61P17/04
Inventor 武志红武志华巩克波李淑玲刘凯周靖巩丽王玖玲张潇丹
Owner SHANDONG UNIV QILU HOSPITAL
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