Application of total matrine in preparing medicine for treating vulva lichen sclerosus

A technology of matrine total alkaloids and matrine, which is applied in the field of chemical medicine, can solve the problems of refractory, long course of disease, easy recurrence and repeated disease, and achieve the effect of reducing the degree of vaginal pain and relieving the symptoms of vaginal itching

Inactive Publication Date: 2020-08-14
GUIYANG XINTIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Generally speaking, VLS is a common and difficult gynecological disease with a long course of disease and difficult to cure. Western medicine has not yet concluded its exact etiology and pathogenesis. Patients lose confidence in long-term treatment, causing great physical and mental pain

Method used

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  • Application of total matrine in preparing medicine for treating vulva lichen sclerosus
  • Application of total matrine in preparing medicine for treating vulva lichen sclerosus
  • Application of total matrine in preparing medicine for treating vulva lichen sclerosus

Examples

Experimental program
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Effect test

Embodiment 1

[0031] This embodiment provides the application of matrine total alkaloids in the preparation of medicine for the treatment of vulvar lichen sclerosus. The dosage form of the medicine is a gel, and the components of the gel include: oxymatrine Alkaline 2%, matrine 0.83%, carbomer (carbomer 940) 5%, solvent (water) 92.17%; wherein, the mass ratio of matrine and oxymatrine is 1:2.4.

[0032] The preparation method of the gel can be carried out with reference to the preparation method of the traditional Chinese medicine gel in the prior art. For the sake of brevity, this embodiment will not describe it.

Embodiment 2

[0034] This example is the clinical curative effect and safety verification test of the gel containing matrine total alkaloids provided in Example 1.

[0035] 1. Diagnostic criteria

[0036] TCM diagnostic criteria refer to "Gynecology of Traditional Chinese Medicine (3rd Edition)", specific diagnostic criteria are as follows: genital itching, pain, restlessness, such as insects, or chapped, dry, or unbearable burning, and even spread to the perineum or anus , accompanied by yellow leucorrhea, large amount and foul smell.

[0037] Western medicine clinical diagnostic criteria refer to the 9th edition of "Obstetrics and Gynecology". The specific content is as follows:

[0038] (1) Symptoms: The main manifestations are severe itching, pain and burning sensation of the vulva skin in the lesion area, even accompanied by dyspareunia or dyspareunia.

[0039] (2) Signs: hyperkeratosis, atrophy, and thinning of the skin in the lesion area of ​​the vulva. Skin depigmentation, whiteni...

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Abstract

The present invention provides an application of total matrine in preparing a medicine for treating vulva lichen sclerosus. The total matrine comprises a combination of matrine and oxymatrine and realizes treatment of the vulva lichen sclerosus in pharmaceutical dosages of gels, suppositories, effervescing agents, ointments, etc. Clinical experiments show that the gel of the total matrine can effectively alleviate symptoms of pruritus vulvae in a shorter time, significantly reduces vaginal pain degrees, and enables a total effective rate of patients with the vulva lichen sclerosus to reach 83%. The application of the provided total matrine provides a theoretical basis for studying a treatment strategy of the vulva lichen sclerosus and provides an embedding point for preparing the new medicine for the vulva lichen sclerosus.

Description

technical field [0001] The invention belongs to the technical field of chemistry and medicine, and in particular relates to the application of matrine total alkaloids in the preparation of medicines for treating vulvar lichen sclerosus. Background technique [0002] Vulva lichen sclerosus (VLS) is a disease characterized by atrophy and thinning of the vulva and perianal skin, which belongs to the white lesions of the vulva. The clinical manifestations are itching of vulvar skin, dyspareunia or dyspareunia, burning sensation or pain. The disease is a chronic disease of the skin and mucous membrane of the female external genitalia, characterized by intractable genital itching, local skin hypopigmentation, whitening and wrinkling of the skin and mucous membrane, poor elasticity, or accompanied by ulcers, or even atrophy and embedding of the clitoris, labia minora Atrophy and the inner side of the labia majora are fused to completely disappear, and the main feature is contractu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K9/06A61P15/00A61P17/04
CPCA61K9/0034A61K9/06A61K36/489A61K47/32A61P15/00A61P17/04
Inventor 王歆玮邢发萍王月丽王萍吕明张杰
Owner GUIYANG XINTIAN PHARMA CO LTD
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