The invention relates to an oral multiparticle pharmaceutical
dosage form in the form of a receptacle reducing the pH values of
stomach, containing a plurality of
pellets, particles, granules or agglomerates whose
mean diameter ranges from 50 to 2500 μn substentially consisting of a) an internal matrix layer containing an
active agent which is neither
peptide or
protein, nor the derivatives or conjugates thereof, a lipophilic matrix whose
melting point is greater than 37° C. and a
polymer with mucoadhesive effect, b) an external
film coating substentially consisting of a
polymer or an anionic
copolymer which is optionally formulated with conventional pharmaceutical additives, wherein the
active agent has a water
solubility according to DAB 10, of at least 30 volume parts of water for one part by weight of the
active agent and is coated with the lipophilic matrix and said active agent-containing lipophilic matrix is coated with a matrix made of a
polymer with mucoadhesive effect. A method for producing the inventive multiparticle pharmaceutical dosage is also disclosed.