36 results about "Absorption drugs" patented technology

Bioabsorbable drug delivery devices including modular drug delivery devices having shapes and sizes adapted to be inserted within a recess on the surface of an implantable prosthesis are disclosed. The devices may be attached to one another to create custom drug delivery devices having controllable drug release characteristics that depend on the composition of individual modules comprising the device. The modules may be cylinders, disks, tiles or tubes comprised of a bioabsorbable polymer and a therapeutic agent. The therapeutic agent(s) may be homogeneously distributed throughout the polymeric body of the device or contained within a cavity within a module comprising the device, or both. The device(s) may be threaded or attached to a prosthesis by a biodegradable adhesive. The modular devices may also be formed into tapered plugs for insertion into a mating receptacle. In another embodiment, the drug delivery device may be inserted within a mesh bag that may be attached to a soft tissue as, for example, by sutures, for localized controlled dispensation of a therapeutic agent.

A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.

The invention discloses a nitrocotton absorption agent mass or block crushing device comprising a frame. A vertical agent box is arranged on the frame. A motor is arranged on the frame on one side of the agent box. A hopper is arranged on the top of the agent box. A discharge port is arranged on the bottom of the agent box. Three levels of crushing mechanisms are sequentially arranged from top to bottom in the agent box. Each level of crushing mechanism is formed by two teeth-type tearing rods arranged in parallel and on a same height. Spaces are arranged between the largest outer diameters of the two tearing rods of the first level of crushing mechanism and the second level of crushing mechanism. The three levels of crushing mechanisms are driven by motors. With the device provided by the invention, defects of non-uniform nitrocotton particle size, high risk degree, intensive labor, low working efficiency, and the like of existing nitrocotton absorption agent mass or block crushing processes. With the device, continuous crushing and human-machine isolation are realized. The process is simple and reliable, and the procedure is safe. The obtained absorption agent particles are uniform, and can be directly applied in subsequent processes.

The invention discloses a fixed dressing for PICC-associated dermatitis in oncology department, relates to the technical field of auxiliary treatment equipment for postoperative wounds, and aims at the existing dressings which are easy to be misplaced in use position, inconvenient to replace the dressing, and the use rate of static dressing is low, and the wound In view of problems such as slow surface recovery, the following scheme is now proposed, including a storage box, the two sides of the storage box are fixedly connected with a connecting mechanism, and the connecting mechanism includes a cover plate, and a mounting plate is welded on the bottom of the cover plate. The outer ring of the mounting plate is provided with a connecting plate, which is welded with the outer wall of the storage box, and a cavity is opened in the connecting plate. The invention has a novel design structure, the position of the dressing is fixed simply and quickly, reducing the workload of medical staff, the bandage is elastic and the patient’s movement will not affect the degree of tightness, and the dressing is used for temperature control and heating to improve the recovery effect of the drug, which is beneficial to the absorption of the drug by the affected part, and assists in healing Speed, reduce patient discomfort, suitable for popularization.

The invention discloses application of P-glycoprotein inhibitor Gelucire44 / 14 serving as an orally-administrated berberine hydrochloride absorption enhancer. Gelucire44 / 14 serves as a P-glycoprotein inhibitor and can inhibit action of a P-glycoprotein teat pipette, so that absorption of berberine hydrochloride difficult to absorb is improved, and the bioavailability of berberine hydrochloride is improved; toxicity inspection results indicate that Gelucire44 / 14 causes no obvious damage to a mucous membrane on the oral administration absorption part, and thus it can be deduced that Gelucire44 / 14 is a safe orally-administrated absorption enhancer; the oral administration bioavailability of berberine hydrochloride difficult to absorb is improved, and Gelucire44 / 14 can be used for preparing an orally-administrated preparation of berberidaceae isoquinoline alkaloid berberine hydrochloride which is difficult to absorb.

Bioactive agents are embedded in a cross-linked dextran and coated with a bioresorbable polymer. When implanted in a mammal, the coated cross-linked dextran composition produces controlled release of the embedded bioactive agent.

The invention discloses the application of DSPE-PEG polymer as oral and pulmonary absorption enhancer. As an absorption enhancer, DSPE-PEG polymer can significantly improve the oral and pulmonary absorption of water-soluble macromolecular refractory drugs; at the same time, the toxicity test results show that DSPE-PEG polymer has no obvious damage to the mucosa at the oral and pulmonary absorption sites, so DSPE‑PEG polymer is a safe absorption enhancer, which can be used in the oral and pulmonary absorption preparations of macromolecular drugs to improve the refractory absorption of water-soluble macromolecular drugs, especially the oral and pulmonary absorption of protein peptide drugs. Utilization.

The invention discloses a novel thermo-sensitive transparent biocompatible material, which consists of four monomers, namely 2-hydroxyethyl methacrylate (HEMA), N-vinyl pyrrolidone (NVP), methyl methacrylate (MMA) and acrylamide (AM). The thermo-sensitive transparent biocompatible material is copolymer hydrogel synthesized by a thermal polymerization method, and the optimum ratios of the four monomers are disclosed. The thermo-sensitive transparent biocompatible material is high in moisture content and high in light transmittance, has the advantages of flexibility and comfort, has transparency and a thermo-sensitive characteristic, has a bright application prospect in aspects of the release and absorption of heavy metals, the control and release of medicines and the like, and is suitable for corneal contact lens materials for sustained-release medicines.

The invention provides an externally-used traditional Chinese medicine composition for treating migraine. According to the composition, ligusticum wallichii is taken as a monarch drug in a prescription; fructus viticis, radix angelicae and notopterygium root for dispelling wind and relieving pain are taken as ministerial drugs; rhizoma corydalis is used for assisting in the monarch drug, the ministerial drugs are used for relieving pain, radix achyranthis bidentatae is used for ensuring proper downward flow of blood, and all the drugs are taken adjuvant drugs; and platycodon grandiflorum is taken a conductant drug. The drugs are combined for clearing upward flow and reducing downward flow, clearing heat in head, bringing illness out and rising qi while reducing heat so as to achieve the effects of dispersing blood stasis, dispelling wind and relieving pain. The drugs can be coordinated by honey. The traditional Chinese medicine composition is applied to acupoints of Yifeng, Geshu, Fengshi, Yongquan and Taichong on the two sides of a human body. The traditional Chinese medicine composition is reasonable in combination, and can be used for fulfilling the effects of dispersing blood stasis, relaxing bowels, dispelling wind and relieving pain in a comprehensive manner. Modern researches show that when the traditional Chinese medicine composition is applied to the corresponding acupoints, the traditional Chinese medicine composition can be better absorbed through the specific parts, the acupoints can be stimulated, meridian qi of main and collateral channels can be excited, the dual functions of the composition and the main and collateral channels can be brought into play, and thus the aim of preventing and treating diseases can be achieved. The total effective rate of the externally-used traditional Chinese medicine composition is up to 89.8%.

The present invention discloses application of Spermine NONOate used as an absorption enhancer of macromolecular indigestible drugs administered by the lung. Spermine NONOate can be used as an absorption enhancer to improve pulmonary absorption of macromolecular indigestible drugs. Meanwhile, the results of toxicity investigation show that Spermine NONOate has no obvious damage to the mucosa of the pulmonary absorption site. It can be known that Spermine NONOate is a safe and reliable absorption enhancer, can improve the absorption of macromolecular indigestible drugs, especially the bioavailability of protein peptide drugs of pulmonary absorption, and can be applied in the preparation of a pulmonary absorption preparation for the macromolecular indigestible drugs.