Administration method for transferring zinc oxide nano-particles into brain through gustatory nerves

Abstract

The invention discloses an administration method for transferring zinc oxide nano-particles into brain through gustatory nerves, the administration method comprises the following steps: preparing a zinc oxide nano-particle suspension, dropwise adding the zinc oxide nano-particle suspension on the tongue according to the body weight so that the zinc oxide nano-particle suspension is uniformly distributed on the whole tongue tissue, and after the administration is finished, repeatedly flushing the tongue with sterile water, and wiping with a sterile cotton swab until the residual zinc oxide nanoparticle suspension on the tongue is thoroughly removed. The zinc oxide nano-particles have excellent rational properties such as small particle size, large specific surface area, high biological activity and the like, and medicines can be transferred into the brain by utilizing gustatory nerves in a tongue body administration mode. The tongue tissue has the advantages of large surface area, high absorption speed and the like, and can quickly absorb the medicine; meanwhile, external interference can be effectively removed through tongue body instillation, and the situation that medicine is transferred to the whole body along with blood is reduced. The whole body action of the medicine can be avoided, the dosage of the medicine can be reduced and the action efficiency of the medicine can be improved.

Description

technical field [0001] The invention belongs to the technical fields of biology, medicine, prevention, materials, etc., and relates to a special drug delivery method of zinc oxide nanoparticles, in particular to a drug delivery method targeting brain via nerve transport. Background technique [0002] There are many ways for nanoparticles to be transported into the brain. First, they can be absorbed into the blood through intravenous injection, intraperitoneal injection, gavage, etc., and then enter the brain through blood circulation; second, they can enter the lymphatic tissue and be transported into the brain through the lymphatic system; Third, through nasal drip, intranasal inhalation, intraocular drip, etc., it is transported into the brain through peripheral nerves. The manner in which nanoparticles are transported into the brain depends largely on the method of administration. Among the existing drug delivery methods, the method of nerve transport into the brain is m...

AI Technical Summary

Problems solved by technology

[0003] The current method of nerve transport into the brain is mainly through the olfactory nerve, followed by the optic nerve and ear nerve, which largely depends on the method of administration. There is no drug administration method for the taste nerve.

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